 | Will Smith als Oscar (voice) |
 | Robert De Niro als Don Lino (voice) |
 | Renée Zellweger als Angie (voice) |
 | Jack Black als Lenny (voice) |
 | Angelina Jolie als Lola (voice) |
 | Ziggy Marley als Ernie (voice) |
 | Martin Scorsese als Sykes (voice) |
 | David P. Smith als Crazy Joe (voice) |
 | Doug E. Doug als Bernie (voice) |
 | Michael Imperioli als Frankie (voice) |
 | Vincent Pastore als Luca (voice) |
 | Peter Falk als Don Feinberg (voice) |
 | Katie Couric als Katie Current (voice) |
 | Phil LaMarr als Prawn Shop Owner (voice) |
 | Shelley Morrison als Mrs. Sanchez (voice) |
 | David Soren als Shrimp / Worm / Starfish #1 / Killer Whale #2 (voice) |
 | Bobb'e J. Thompson als Shortie #1 (voice) |
 | Kamali Minter als Shortie #2 (voice) |
| Emily Lyon Segan als Shortie #3 (voice) |
 | Lenny Venito als Giuseppe / Great White #1 (voice) |
 | Saverio Guerra als Pontrelli (voice) |
 | Mark Swift als Announcer (voice) |
 | James Madio als Great White #2 / Hammerhead (voice) |
 | Frank Vincent als Great White #3 (voice) |
 | Joseph Siravo als Great White #5 (voice) |
| Steve Alterman als Messenger Fish / Tip Fish #2 (voice) |
 | Jenifer Lewis als Motown Turtle (voice) |
| Sean Bishop als Tip Fish #1 / Great White #4 / Whale / Killer Whale #1 (voice) |
 | James Ryan als Cashier / Oyster / Clown Whale (voice) |
 | Latifa Ouaou als Whale Wash Co-Worker (voice) |
| David Yanover als Taxi Fish (voice) |
 | Missy Elliott als Missy (voice) (uncredited) |
 | Christina Aguilera als Christina (voice) (uncredited) |
| Rob Letterman | Screenplay |
| Michael J. Wilson | Screenplay |
| Bill Damaschke | Producer |
| Janet Healy | Producer |
| Allison Lyon Segan | Producer |
| Hans Zimmer | Original Music Composer |
| Peter Lonsdale | Editor |
| John Venzon | Editor |
| Steve Cunningham | Animation |
| Simon Otto | Animation |
| Jean-Francois Rey | Animation |
| Seth Engstrom | Art Direction |
| Fabrice Joubert | Supervising Animator |
| David P. Smith | Additional Dialogue |
| Andrea Blasich | Sculptor |
| Tom Holkenborg | Additional Music |
| Michael Bauer | CG Supervisor |
| Nadine Colquhoun | Choreographer |
| Miles DeLong | Post Production Assistant |
| Andrew Birch | Post Production Supervisor |
| Charlotte Manning | Software Engineer |
| Scott Ballard | Technical Supervisor |
| Scott Chapin | Systems Administrators & Support |
| Terry Claborn | Color Timer |
| Joseph R. Thygesen | First Assistant Editor |
| Cathy E. Blanco | Lighting Artist |
| Shauna M. Stevens | Lighting Technician |
| Jeffrey Katzenberg | Executive Producer |
| Christi Soper Hilt | Casting Associate |
| Andrea McCarthy Paul | Production Accountant |
| Ryan Harris | Production Coordinator |
| Cameron Stevning | Production Manager |
| Brian Behling | Production Supervisor |
| Alicia Reyes Alonzo | Researcher |
| Robert Morrisey | First Assistant Sound Editor |
| Melissa Muik | Music Editor |
| Darren Higman | Music Supervisor |
| Wade Wilson | Sound Designer |
| Mark A. Mangini | Sound Effects Editor |
| Erin Michael Rettig | Sound Engineer |
| Anna Behlmer | Sound Re-Recording Mixer |
| Richard L. Anderson | Supervising Sound Editor |
| Daniel Miller | Digital Compositors |
| Sunny Apinchapong | Visual Development |
| John Dowell | Visual Effects |
| Bernard O. Ceguerra | Sequence Leads |
| Jeffrey Wike | Software Team Lead |
| Abhay Manusmare | Score Engineer |
| Matthew Paulson | Modeling |
| Dan St. Pierre | Production Design |
| Scott Aukerman | Additional Dialogue |
| BJ Porter | Additional Dialogue |
| Alec Berg | Additional Dialogue |
| Ralph Osborn | ADR Editor |
| Doug Cooper | Visual Effects Supervisor |
| Jorge del Valle | Title Designer |
| Mo Henry | Negative Cutter |
| Celeste Leger | Casting Assistant |
| Ray Felipe | Script Researcher |
| Andy Sisul | Assistant Sound Editor |
| Thorsten Laewe | Music Programmer |
| Patrick Mate | Character Designer |
| Alessandro Carloni | Lead Animator |
| Mark Swift | Associate Producer |
| David Williams | Dialogue Editor |
| Craig Heath | Sound Recordist |
| Wayne Hellinger | Post Production Coordinator |
| Denise Koyama | Storyboard Artist |
| Derek Casari | ADR Engineer |
| Troy Porter | ADR Mixer |
| John T. Cucci | Foley Artist |
| James Ashwill | Foley Mixer |
| Dawn Turner | Visual Effects Production Assistant |
| Justin Miller | Animation Technical Director |
| Gabriele Pennacchioli | Senior Animator |
| Mary Blee | Assistant Editor |
| Jeff Olm | Digital Colorist |
| Nick Fletcher | Lead Editor |
| Laura Webb | Music Coordinator |
| Ryeland Allison | Music Programmer |
| Mary M. Quinn | Administrative Assistant |
| Marc Scott | Compositing Supervisor |
| David Soren | Head of Story |
| Patrick Canning | Production Assistant |
| Kristina Reed | Production Executive |
| Sean Bishop | Story Artist |
| Mike de Seve | Story Consultant |
| Lona Williams | Writer |
| Bibo Bergeron | Director |
| Rob Letterman | Director |
| Vicky Jenson | Director |
| Gabe Hordos | Animation |
| Gil Zimmerman | Director of Photography |
| Gil Zimmerman | Head of Layout |
| Christina Aguilera | Songs |
| Missy Elliott | Songs |
| Laura Ziffren | Music Supervisor |
| Peter Burgis | Foley Artist |
| Andie Derrick | Foley Artist |
| Kevin Rafferty | CGI Supervisor |
