 | Kirstie Alley als Marjorie Turner |
 | Bill Pullman als Nicholas Meany |
 | Carrie Fisher als Iris Turner-Hunter |
 | Jami Gertz als Jeanine |
 | Scott Bakula als Harry Turner |
 | Frances Sternhagen als Rose Turner |
 | John Randolph als Charles Turner, Sr. |
 | Sam Elliott als Charles Turner, Jr. |
 | Ed O'Neill als Wilbur Meany |
 | Bill Macy als Pat |
 | Matthew Laurance als Dr. Casey Hunter |
 | Paul Benedict als Dr. Plotner |
 | Ron Orbach als Don, the Desk Clerk |
| Carl Reiner | Director |
| Don Miller | Producer |
| David V. Lester | Producer |
| Howard West | Executive Producer |
| Durinda Wood | Costume Design |
| Reynaldo Villalobos | Director of Photography |
| Liz Glotzer | Producer |
| Bud Molin | Editor |
| Martha Goldhirsh | Writer |
| Jeannine Oppewall | Production Design |
| Marci Liroff | Casting |
| George Shapiro | Executive Producer |
| Janet Gilmore | Casting Assistant |
| Lisa Fischer | Set Decoration |
| Todd McIntosh | Key Makeup Artist |
| Gerald Quist | Makeup Artist |
| Susan Schuler-Page | Hairstylist |
| Candida Conery | Key Hair Stylist |
| Jack Elliott | Original Music Composer |
