 | Michael Angarano als Will Stronghold |
 | Mary Elizabeth Winstead als Gwen Grayson / Royal Pain |
 | Kurt Russell als Steve Stronghold / The Commander |
 | Kelly Preston als Josie Stronghold / Jetstream |
 | Danielle Panabaker als Layla Williams |
 | Bruce Campbell als Coach Boomer |
 | Lynda Carter als Principal Powers |
 | Kevin Heffernan als Ron Wilson, Bus Driver |
 | Dee Jay Daniels als Ethan |
 | Kelly Vitz als Magenta |
 | Loren Berman als Little Larry |
 | Nicholas Braun als Zachary "Zach" Braun / Zack Attack |
 | Steven Strait als Warren Peace |
 | Malika als Penny |
 | Khadijah Haqq McCray als Penny |
 | Jake Sandvig als Lash |
 | Will Harris als Speed |
 | Dustin Ingram als Carbon Copy Kid |
 | Christopher Wynne als News Anchor |
 | Cloris Leachman als Nurse Spex |
 | Jim Rash als Mr. Grayson / Stitches |
 | Dave Foley als Mr. Boy |
 | Kevin McDonald als Mr. Medulla |
| Amy Brown als Twin |
| Kimmy Brown als Evil Twin |
 | Lucille Soong als Cook |
| Zachry Rogers als Young Commander |
 | Tom Kenny als Mr. Timmerman |
 | Jill Talley als Mrs. Timmerman |
 | Patrick Warburton als Royal Pain (voice) |
| Vakisha Coleman als Student Sidekick (uncredited) |
| Sean Gordon als Penny's Date (uncredited) |
 | Hans Hernke als Laser-Vision Boy (uncredited) |
 | Jason Maxim als Funky Prom Boy (uncredited) |
| Andrew Gunn | Producer |
| Ann Marie Sanderlin | Executive Producer |
| Michael Giacchino | Original Music Composer |
| Peter Amundson | Editor |
| Shelly Johnson | Director of Photography |
| Mike Mitchell | Director |
| Mario Iscovich | Executive Producer |
| Bob Schooley | Writer |
| Allison Jones | Casting |
| Mark McCorkle | Writer |
| William Hawkins | Art Direction |
| Bruce Robert Hill | Production Design |
| Robert Gould | Set Decoration |
| Michael Wilkinson | Costume Design |
| Paul Hernandez | Writer |
| Susan Germaine | Hair Department Head |
| Jane English | Makeup Artist |
| Jay B. Richardson | Music Editor |
| David Kern | Sound Effects Editor |
| Christina Smith | Makeup Department Head |
| Pamela Alch | Script Supervisor |
| John E. Jackson | Makeup Artist |
| Dean A. Zupancic | Sound Re-Recording Mixer |
| Todd Toon | Supervising Sound Editor |
| Tom Rebber | Transportation Coordinator |
| Susan Carol Schwary | Hairstylist |
| Candace Neal | Key Hair Stylist |
| Sam Emerson | Still Photographer |
| Lisa Brown | Music Supervisor |
| Donald J. Malouf | Supervising Sound Editor |
| June Brickman | Makeup Artist |
| Suzanne Tenner | Still Photographer |
| Stephen M. Davis | Music Editor |
| Adam Kopald | Sound Effects Editor |
| Richard Bloom | Art Department Coordinator |
| Terry Porter | Sound Re-Recording Mixer |
| Paul Ledford | Production Sound Mixer |
| Dottie Starling | CGI Supervisor |
| Kimberly Lowe Voigt | Dialogue Editor |
| G.W. Brown | Supervising ADR Editor |
| John Kwiatkowski | Dialogue Editor |
| Heidi Moneymaker | Stunts |
| Monica Staggs | Stunts |
| Jon H. Epstein | Stunt Coordinator |
| Darrin Prescott | Stunts |
