 | Amy Schumer als Emily Middleton |
 | Goldie Hawn als Linda Middleton |
 | Tom Bateman als James |
 | Christopher Meloni als Roger Simmons |
 | Wanda Sykes als Ruth |
 | Ike Barinholtz als Jeffrey Middleton |
 | Óscar Jaenada als Morgado |
 | Randall Park als Michael |
 | Joan Cusack als Barb |
 | Raven Goodwin als Lew |
 | Arturo Castro als Dr. Armando |
 | Bashir Salahuddin als Morgan Russell |
 | Nicholas J. Lockwood als Jacob |
| Pedro Haro als Maco |
 | Katie Dippold als Shopper |
| Kim Caramele als Shopper |
 | Daniel Bess als Front Desk Clerk |
 | Moani Hara als Hot Woman |
 | Carlos Diaz als Guitar Player / Singer |
| Damion Scandrick als Tattooed Kidnapper |
| Andre Derizans als Kidnapper #2 |
| Modesto Cordero als Pickup Truck Driver |
| Sergio Sanchez als Teen Bartender |
 | Jason Quinn als Crew Member |
 | Linda Molina als Female Villager |
 | Al Madrigal als Embassy Official |
| Erik-Alexander Sanchez als Embassy Worker |
 | Tom Choi als Colonel |
 | Kevin Kane als Hot Guy |
 | Jenny Babas als Dancer (uncredited) |
| Miguel A. Baez Jr. als Henchman (uncredited) |
 | Francis Benhamou als Colombian Army Commander (uncredited) |
| Raj K. Bose als Equadorian Bar Patron (uncredited) |
 | Svitlana Campbell als Hotel Guest (uncredited) |
 | Sasha Chuidian als Rioter (uncredited) |
 | Wolf Lee Counsel als Restaurant Patron (uncredited) |
 | Victoria Current als Prostitute (uncredited) |
| Shaun Dunnigan als Security Guard (uncredited) |
 | Cody Easterbrook als Busboy (uncredited) |
 | Jiaoying Liang als Dancer (uncredited) |
 | Cat Limket als Beautiful Village Girl (uncredited) |
| Shawn McBride als International Hotel Guest (uncredited) |
 | Andre Pelzer als International Hotel Guest (uncredited) |
| Ty Quiamboa als Bartender (uncredited) |
| Sandy Ritz als Hotel Guest (uncredited) |
 | Scott M. Schewe als International Hotel Guest (uncredited) |
 | David James Sikkink als International Hotel Guest (uncredited) |
 | Rebecca Teresia als International Hotel Guest (uncredited) |
| Luis R. Espinoza als Taxi Driver |
| Jonathan Levine | Director |
| Katie Dippold | Writer |
| Amy Schumer | Screenplay |
| Kim Caramele | Screenplay |
| Florian Ballhaus | Director of Photography |
| Zene Baker | Editor |
| Kevin Constant | Art Direction |
| Chryss Hionis | Set Decoration |
| Tod A. Maitland | Sound Mixer |
| Brent Anbe | Casting Associate |
| Phillip Howard | Costume Design |
| Dana Kay Hart | Costume Supervisor |
| Brian Machleit | Stunt Coordinator |
| Kevin Hannigan | Special Effects Coordinator |
| Peter Chernin | Producer |
| Paul Feig | Producer |
| Jessie Henderson | Producer |
| Michael Kruzan | Producer |
| Donald J. Lee Jr. | Executive Producer |
| Kim Caramele | Executive Producer |
| Tonia Davis | Executive Producer |
| Katie Dippold | Executive Producer |
| Kevin Kane | Associate Producer |
| Amy Schumer | Executive Producer |
| Jenno Topping | Producer |
| Chris Bacon | Original Music Composer |
| Theodore Shapiro | Original Music Composer |
| Melissa Bretherton | Editor |
| Mark Ricker | Production Design |
| Leesa Evans | Costume Design |
| Joan Kelley Bierman | Post Production Supervisor |
| Kate Kelly | Production Supervisor |
| Stella Vaccaro | Set Designer |
| Julie Hannum | Location Manager |
| Stephanie Spangler | Location Scout |
| Gabe Hilfer | Music Supervisor |
| Brenda Lopez | Script Supervisor |
| Julia Gadiana | Hairstylist |
| Nicki Ledermann | Makeup Department Head |
| Ralph Malani | Hairstylist |
| Pavy Olivarez | Key Hair Stylist |
| Laine Rykes | Key Makeup Artist |
| Joy Zapata | Hair Department Head |
| E. J. Foerster | Second Unit Director |
| Artist W. Robinson | First Assistant Director |
| Deanna Stadler | Second Assistant Director |
| Robert A. Blackburn | Construction Coordinator |
| Yann Denoual | Sculptor |
| Jane Gulick | Property Master |
| Gary Nakano | Graphic Designer |
| William H. Phen Jr. | Construction Foreman |
| Isaia Robins | Greensman |
| Joelle-Lyn Sarte | Art Department Coordinator |
| Ben Woodworth | Painter |
| Roberto Dominguez Alegria | Foley Mixer |
| Ignacio Arrojo | ADR Recordist |
| John T. Cucci | Foley Artist |
| Susan Dawes | Supervising Dialogue Editor |
| Joel Dougherty | Sound Re-Recording Mixer |
| Jay Fisher | ADR Mixer |
| Warren Hendriks | Supervising Sound Editor |
| David Lucarelli | ADR Recordist |
| Sean Massey | Supervising ADR Editor |
| Dan O'Connell | Foley Artist |
| Jason Oliver | ADR Mixer |
| Chris Terhune | Sound Designer |
| Jerry Yuen | Boom Operator |
| Thomas F. Ford IV | Visual Effects Producer |
| David Lingenfelser | Visual Effects Supervisor |
| Rebecca Park | Visual Effects Producer |
| Jason Solberg | Visual Effects Editor |
| Rene Mousseux | Stunt Double |
| Ryan Gray | Stunt Double |
| Lisa Hoyle | Stunt Double |
| Damien Bray | Stunts |
| Bonnie Campanella | Utility Stunts |
| Craig H. Davidson | Stunts |
| Jess Lundgren | Stunts |
| Gary Price | Stunts |
| Meredith Richardson | Stunt Double |
| Mike Rufino | Stunts |
| Jason A. Triplett | Stunts |
| Todd Sells | Stunt Double |
| Rylan Akama | Assistant Camera |
| John Bonnin | Libra Head Technician |
| Don Chong | Dolly Grip |
| Andy Day | Gaffer |
| Jason Ellson | Steadicam Operator |
| Don King | Camera Operator |
| Thomas Lappin | Camera Operator |
| Caleb Lucero | Second Assistant Camera |
| Vince Keala Lucero | Camera Operator |
| Duane Manwiller | Second Unit Director of Photography |
| Charlie Marroquin | Key Grip |
| Justina Mintz | Still Photographer |
| Allen Mozo | Lighting Technician |
| David B. Nowell | Aerial Director of Photography |
| Ryan Rayner | First Assistant "A" Camera |
| Marc 'Aina' Ribuca | Electrician |
| Andrew Sweeney | Dolly Grip |
| Don Tomich | Rigging Gaffer |
| Eirinn Disbrow | Assistant Editor |
| Jamie Keeney | Assistant Editor |
| Ken O'Keefe | First Assistant Editor |
| Allegra De Souza | Music Editor |
| Zoila Gomez | Production Coordinator |
| Cecile Meloni | In Memory Of |
| Karen Teneyck | Graphic Designer |
| Rick Lovoy | Driver |
| Alejandro Uribe Holguín | ADR Recordist |
| Tom Brown | Music Arranger |
