 | Dustin Hoffman als Dr. Norman Goodman |
 | Sharon Stone als Dr. Elizabeth 'Beth' Halperin |
 | Samuel L. Jackson als Dr. Harry Adams |
 | Peter Coyote als Captain Harold C. Barnes |
 | Liev Schreiber als Dr. Ted Fielding |
 | Queen Latifah als Alice 'Teeny' Fletcher |
 | Marga Gómez als Jane Edmunds |
 | Huey Lewis als Helicopter Pilot |
 | Bernard Hocke als Seaman |
 | James Pickens Jr. als O.S.S.A. Instructor |
 | Michael Keys Hall als O.S.S.A. Official |
 | Ralph Tabakin als O.S.S.A. Official |
| Barry Levinson | Director |
| Barry Levinson | Producer |
| Adam Greenberg | Director of Photography |
| Andrew Wald | Producer |
| Stu Linder | Editor |
| Paul Attanasio | Screenplay |
| Elliot Goldenthal | Original Music Composer |
| Stephen Hauser | Screenplay |
| Michael Crichton | Producer |
| Anne Kuljian | Set Decoration |
| Mark W. Mansbridge | Art Direction |
| Gloria Gresham | Costume Design |
| James W. Tyson | Costume Supervisor |
| Jonathan McKinstry | Art Direction |
| Norman Reynolds | Production Design |
| Ellen Chenoweth | Casting |
| Heather Harris | Script Supervisor |
| Marietta Carter-Narcisse | Makeup Artist |
| Marian Wilde | Sound Effects Editor |
| Michael Silvers | Supervising Dialogue Editor |
| Charles John Bukey | Key Grip |
| Walter F. Hyneman | CG Supervisor |
| Gary Capo | Second Unit Director of Photography |
| P. Scott Sakamoto | Steadicam Operator |
| Allan A. Apone | Key Makeup Artist |
| Ian Fox | Underwater Camera |
| Steven C. McGee | Chief Lighting Technician |
| Tricia Sawyer | Makeup Artist |
| Fernando Benítez | CGI Supervisor |
| Tim Gibbons | Roto Supervisor |
| Allen D. Easton | Camera Operator |
| Robert Bardy | CGI Supervisor |
| Brian Hamill | Still Photographer |
| Nicole Herr | 3D Animator |
| Ronald A. Miller | Rigging Grip |
| Michael Kory | CGI Supervisor |
| Rod Basham | Visual Effects Editor |
| Mary Helen Leasman | Sound Effects Editor |
| Tom Johnson | Sound Re-Recording Mixer |
| Aaron Dem | Visual Effects Producer |
| John Quaglia | Hairstylist |
| Catherine Childers | Key Hair Stylist |
| Robert Ryan | Makeup Artist |
| Lora Hirschberg | Sound Re-Recording Mixer |
| Adrienne Manhan | Key Costumer |
| Carlos Arguello | Visual Effects Supervisor |
| Mark Daily | First Assistant Editor |
| Lindakay Brown | ADR Editor |
| Gary Thomas | Boom Operator |
| Brad Emmons | Rigging Gaffer |
| Jeffrey A. Okun | Visual Effects Supervisor |
| Michael White | Hairstylist |
| June Westmore | Makeup Artist |
| Jeff Lin | CGI Supervisor |
| Jason Wardle | CGI Supervisor |
| Karen Klein | Roto Supervisor |
| Lydia Bottegoni | Visual Effects Producer |
| Jana Vance | Foley |
| J.R. Grubbs | Sound Effects Editor |
| Tim Holland | Supervising Sound Editor |
| Mark Boley | Hair Supervisor |
| Mo Henry | Negative Cutter |
| Claire Sanfilippo | ADR Editor |
| Richard Beggs | Sound Designer |
| Julie Pitkanen | Script Supervisor |
| Richard O. Helmer | Special Effects Supervisor |
| Patricia Churchill | Associate Producer |
| Peter Giuliano | Executive Producer |
| David Gabrielli | Construction Foreman |
| Kent Sparling | Mix Technician |
| Michael Greggans | Stand In |
| Michael Meier | Lighting Technician |
| Sean Mannion | Property Master |
| Greg Banta | Gaffer |
| Alex Daniels | Stunt Coordinator |
| R. Gern Trowbridge | Best Boy Electric |
| John Moses | Musician |
| Bill 'Kauhane' Hoyt | Standby Painter |
| Aaron Hakeem | Scenic Artist |
| Michael J. Malone | Unit Manager |
| Christine Dye | Set Production Assistant |
| Marvin Salsberg | Construction Coordinator |
| Nori Honda | Sculptor |
| Kurt E. Soderling | Aerial Camera |
| Joseph D. Urbanczyk | Additional Camera |
| Kurtis Bedford | Carpenter |
| Rodney Hope | Driver |
| Blair Daily | Post Production Supervisor |
| Louis Farah | Set Medic |
| Richard O. Helmer | Special Effects Coordinator |
| Dale E. Grahn | Color Timer |
| Kristen D. Chidel | Production Manager |
| Lee Garibaldi | Transportation Captain |
| Sean Taylor | Production Coordinator |
| John Charles Kohn | Compositor |
| Mary Ellen Leonard | Craft Service |
| Eric Blum | Electrician |
| Mark Scoon | Executive In Charge Of Production |
| Michael John Meehan | Location Manager |
| Patricia Churchill | Unit Production Manager |
| W. Steven Graham | Assistant Art Director |
| Brett C. Smith | Leadman |
| John Giuliano | Propmaker |
| Blair Daily | Additional Editor |
| Denise Morgan McGrath | Production Accountant |
| Robert Elhai | Orchestrator |
| James Conroy | Grip |
| Andrew Nelson | Set Costumer |
| Paul Borne | Stunts |
| Steve Cantamessa | Production Sound Mixer |
| Tom Fox | Video Assist Operator |
| Michael Singer | Publicist |
| Billy R. Brashier | Projection |
| Tommy Tancharoen | Transportation Coordinator |
| William Beck | Set Designer |
| Alan Cohen | First Assistant Camera |
| Peter Albiez | Special Effects |
| Katterli Frauenfelder | First Assistant Director |
| Edward J. Protiva | Set Dressing Artist |
| Claire Sanfilippo | Dialogue Editor |
| Lindakay Brown | Dialogue Editor |
| Jeff Kunkle | Dolly Grip |
| Wayne Baker | Assistant Camera |
| David Krudis | Payroll Accountant |
| Gail Rose | Assistant Accountant |
| Jim Goldthwait | Second Assistant Director |
| Bud Heller | Best Boy Grip |
| Julie Witherington | Assistant Property Master |
| Jonathan Sheffer | Conductor |
| Rose Hlaing | Production Secretary |
| Kurt E. Soderling | Visual Effects Camera |
| Roger Kupelian | Matte Painter |
| Victor Abbene | Chief Lighting Technician |
| Jason Joseph | Assistant Editor |
| Curtis Roush | Supervising Music Editor |
| Stanley L. Gonsales | Assistant Chief Lighting Technician |
| Miles Perlman | Second Second Assistant Director |
| Eric Amundsen | Second Assistant Camera |
| Trent Schultz | Project Manager |
| David R. Ellis | Second Unit Director |
| Dennie Thorpe | Foley Artist |
| Brian Dettor | Location Assistant |
| Stacy De La Motte | Production Assistant |
| Jeff Miller | Special Effects Technician |
| Joe Colwell | Effects Supervisor |
| Randy Starr | Production Executive |
| Coleen Aiello | Second Assistant Accountant |
| Lon R. Shor | VFX Artist |
| Keith Tellez | Stunt Double |
| Bonjin Byun | Digital Compositor |
| Barbara Hartman-Jenichen | Costumer |
| Danny Cangemi | Special Effects Assistant |
| Kurt Mattila | Title Designer |
| Brennan Dufresne | Casting Assistant |
| Nina Henninger | Location Casting |
| Tory Belleci | Carpenter |
| Jim Magdaleno | Storyboard Artist |
| Ronnie Rondell Jr. | Stunt Coordinator |
| Daryl Tucker | VFX Artist |
| Michael Crichton | Novel |
| Tim Rigby | Stunts |
| Lisa McCullough | Stunts |
| Kurt Wimmer | Adaptation |
