 | Chevy Chase als Emmett Fitz-Hume |
 | Dan Aykroyd als Austin Millbarge |
 | Steve Forrest als General Sline |
 | Donna Dixon als Karen Boyer |
 | Bruce Davison als Ruby |
 | Terry Gilliam als Dr. Imhaus |
 | Frank Oz als Test Monitor |
 | Vanessa Angel als Russian Rocket Crewperson |
 | Bernie Casey als Colonel Rhumbus |
 | Charles McKeown als Jerry Hadley |
 | William Prince als Keyes |
 | Bob Hope als Self |
 | Joel Coen als Drive-In Security |
 | Sam Raimi als Drive-In Security |
 | Martin Brest als Drive-In Security |
| Tom Hatten als General Miegs |
 | James Daughton als Bob Hodges |
 | Jim Staahl als Bud Schnelker |
| Bjarne Thomsen als Russian Rocket Crewperson |
 | Sergey Rusakov als Russian Rocket Crewperson |
 | Costa-Gavras als Tadzhik Highway Patrolman |
 | Seva Novgorodtsev als Tadzhik Highway Patrolman |
| Stephen Hoye als Captain Hefling |
 | Ray Harryhausen als Dr. Marston |
 | Mark Stewart als Ace Tomato Courier |
 | Sean Daniel als Ace Tomato Driver |
| Jeff Harding als Fitz-Hume's Associate |
 | Heidi Sorenson als Alice, Fitz-Hume's Supervisor |
| Margo Random als Reporter |
 | Douglas Lambert als Reporter |
| Christopher Malcolm als Jumpmaster |
| Terrance Conder als Soldier #1 |
 | Matt Frewer als Soldier #2 |
| Tony Cyrus als The Khan |
| Gusti Bogok als Dr. La Fong |
| Derek Meddings als Dr. Stinson |
| Robert Paynter als Dr. Gill |
| Gurdial Sira als The Khan's Brother |
 | Michael Apted als Ace Tomato Agent |
 | B.B. King als Ace Tomato Agent |
 | Larry Cohen als Ace Tomato Agent |
 | Ricco Ross als WAMP Guard |
| Richard D. Sharp als WAMP Technician |
 | Stuart Milligan als WAMP Technician |
| Sally Anlauf als WAMP Technician |
| John Daveikis als Russian Border Guard |
| Laurence Bilzerian als Russian Border Guard |
| Richard Kruk als Russian Border Guard |
 | Heather Henson als Teenage Girl |
| Erin Folsey als Teenage Girl |
 | Bob Swaim als Special Forces Commander |
| Nancy Gair als Student (uncredited) |
 | Guy Standeven als Reporter (uncredited) |
| Bernie Brillstein | Executive Producer |
| George Folsey Jr. | Producer |
| Brian Grazer | Producer |
| Elmer Bernstein | Original Music Composer |
| Robert Paynter | Director of Photography |
| Malcolm Campbell | Editor |
| Dan Aykroyd | Screenplay |
| Lowell Ganz | Screenplay |
| Babaloo Mandel | Screenplay |
| John Landis | Director |
| Brian Johnson | Special Effects |
| Leslie Belzberg | Associate Producer |
| Sam Williams | Associate Producer |
| Terry Ackland-Snow | Production Design |
| Peter Murton | Production Design |
| Terry Ackland-Snow | Supervising Art Director |
| Deborah Nadoolman | Costume Design |
| Dan Allingham | Production Supervisor |
| Mohamed Seddik Bouabid | Line Producer |
| Claude Hudson | Production Manager |
| Christopher Knowles | Unit Manager |
| John Palmer | Production Manager |
| Rufus Andrews | Location Manager |
| Peter Elford | Location Manager |
| Nigel Goldsack | Location Manager |
| Stuart Neumann | Location Manager |
| Kathy Durning | Music Editor |
| Marlene Butland | Production Coordinator |
| Pamela Carlton | Script Supervisor |
| Kenneth J. Withers | Camera Operator |
| Derek Meddings | Visual Effects Supervisor |
| Jim Michaels | Visual Effects Producer |
| Greg Powell | Animal Coordinator |
| Greg Powell | Animal Wrangler |
| Greg Powell | Stunts |
| Debbie McWilliams | Casting |
| Marion Dougherty | Casting |
| Dusty Symonds | First Assistant Director |
| Gareth Tandy | Second Assistant Director |
| Nick Heckstall-Smith | Third Assistant Director |
| Chic Anstiss | Camera Operator |
| John Palmer | Camera Operator |
| Ted Deason | Focus Puller |
| David Budd | Focus Puller |
| W.C. 'Chunky' Huse | Grip |
| Tony Turner | Grip |
| David Garfath | Second Unit Director |
| Brian West | Second Unit Director of Photography |
| Ivan Sharrock | Sound Mixer |
| Donald Banks | Boom Operator |
| David Motta | Sound Assistant |
| Jim Morahan | Assistant Art Director |
| Hugh Scaife | Set Dresser |
| Ray Caple | Matte Painter |
| John Paterson | Construction Manager |
| Sue Wain | Wardrobe Supervisor |
| Frank Griffin | Makeup Artist |
| Pauline Heys | Makeup Artist |
| Linda DeVetta | Makeup Artist |
| Stephanie Kaye | Hairdresser |
| Carole Bennett | Hairdresser |
| Janet L. Wattles | Production Accountant |
| Anna Ksiezopolska | Assistant Editor |
| Andrew MacRitchie | Assistant Editor |
| Pattye Rogers | Assistant Editor |
| Lisa Zeno Churgin | Assistant Editor |
| Margaret Adachi | Assistant Editor |
| Susan d'Arcy | Unit Publicist |
| Keith Hamshere | Still Photographer |
| John May | Gaffer |
| Paul Weston | Stunt Coordinator |
| Charles L. Campbell | Supervising Sound Editor |
| Richard C. Franklin | Sound Editor |
| Jerry Stanford | Sound Editor |
| Samuel C. Crutcher | Sound Editor |
| Chuck Neely | Sound Editor |
| Larry Carow | Sound Editor |
| Howard Neiman | Sound Editor |
| Larry Singer | Supervising ADR Editor |
| Alan L. Nineberg | ADR Editor |
| Christopher Palmer | Orchestrator |
| Robert Knudson | Sound Re-Recording Mixer |
| Robert Glass | Sound Re-Recording Mixer |
| Don Digirolamo | Sound Re-Recording Mixer |
| Bob Noland | Color Timer |
| Donah Bassett | Negative Cutter |
| Dan Allingham | Unit Production Manager |
| David Sosna | First Assistant Director |
| Pam Cornfeld | Production Coordinator |
| Queen Elizabeth II of the United Kingdom | Thanks |
| Max Landis | Thanks |
| B.J. Worth | Stunts |
| Nick Wilkinson | Stunts |
| Terry Forrestal | Stunts |
| David Forman | Stunts |
| Jason White | Stunts |
| Malcolm Weaver | Stunts |
| Stuart Fell | Stunts |
| Rocky Taylor | Stunts |
| Michael DeLuna | Stunts |
| Colin Skeaping | Stunts |
| Clive Curtis | Stunts |
| Alan Chuntz | Stunts |
| Terry Cade | Stunts |
| Gerard Naprous | Stunts |
| Lex Milloy | Stunts |
| Ken Buckle | Stunts |
| Peter Brace | Stunts |
