 | Matt Damon als Spirit (voice) |
 | James Cromwell als The Colonel (voice) |
 | Charles Napier als Roy (voice) |
 | Robert Cait als Jake (voice) |
 | Richard McGonagle als Bill (voice) |
 | Donald Fullilove als Train Pull Foreman (voice) |
 | Daniel Studi als Little Creek (voice) |
| Chopper Bernet als Sgt. Adams (voice) |
| Jeff LeBeau als Murphy / Railroad Foreman (voice) |
| John Rubano als Soldier (voice) |
 | Matt Levin als Joe (voice) |
| Adam Paul als Pete (voice) |
| Meredith Wells als Little Indian Girl (voice) |
 | Zahn McClarnon als Little Crrek's Friend (voice) |
 | Michael Horse als Little Creek's Friend (voice) |
| Hans Zimmer | Original Music Composer |
| Jeffrey Katzenberg | Producer |
| Kelly Asbury | Director |
| John Fusco | Screenplay |
| Lorna Cook | Director |
| Max Howard | Executive Producer |
| Mireille Soria | Producer |
| Clare Knight | Editor |
| Bryan Adams | Songs |
| Fabrice Joubert | Animation |
| Dave Kupczyk | Animation |
| Seth Engstrom | Layout |
| Padraig Collins | Animation |
| Simon Otto | Animation |
| Jean-Francois Rey | Animation |
| Mick De Falco | Layout |
| Manny DeGuzman | Animation |
| James Baxter | Animation Supervisor |
| Luc Desmarchelier | Art Direction |
| Gabriele Zucchelli | Animation Supervisor |
| Owen Klatte | Animation |
| Robin Badr | Animation |
| Jean Kalile | Animation |
| Harald Kraut | Layout |
| Michael Isaak | Layout |
| Kathy Altieri | Production Design |
| Ron Lukas | Art Direction |
