 | Tom Kenny als SpongeBob SquarePants / Gary the Snail (voice) |
 | Bill Fagerbakke als Patrick Star (voice) |
 | Rodger Bumpass als Squidward Tentacles (voice) |
 | Mr. Lawrence als Plankton (voice) |
 | Keanu Reeves als Sage |
 | Clancy Brown als Mr. Krabs (voice) |
 | Carolyn Lawrence als Sandy Cheeks (voice) |
 | Matt Berry als King Poseidon (voice) |
 | Jill Talley als Karen (voice) |
 | Mary Jo Catlett als Mrs. Puff (voice) |
 | Awkwafina als Otto (voice) |
 | Snoop Dogg als The Gambler |
 | Danny Trejo als El Diablo |
 | Tiffany Haddish als Master of Ceremonies (voice) |
 | Reggie Watts als Chancellor (voice) |
 | Antonio Raul Corbo als Young SpongeBob (voice) |
 | Jack Gore als Young Patrick (voice) |
 | Jason Maybaum als Young Squidward (voice) |
 | Presley Williams als Young Sandy (voice) |
 | Dee Bradley Baker als Perch Perkins (voice) |
| Kristen Caplan | Production Manager |
| Nick Kenway | Editorial Manager |
| Stephen Hillenburg | Executive Producer |
| Chantal Feghali | Executive Producer |
| Cecilia Hyoun | First Assistant Editor |
| Tim Hill | Director |
| Hans Zimmer | Original Music Composer |
| Chris Scarabosio | Additional Sound Re-Recording Mixer |
| Tom Myers | Supervising Sound Editor |
| Gary Summers | Sound Re-Recording Mixer |
| Tim Hill | Story |
| Glenn Berger | Story |
| Stephen Hillenburg | Characters |
| Jonathan Aibel | Story |
| Tim Hill | Screenplay |
| Jack Kingsley | Stunts |
| Steve Mazzaro | Original Music Composer |
| Peter Lyons Collister | Director of Photography |
| Michael Andrews | Editor |
| Doug Chapman | Stunts |
| Jonathan Goldstein | Creative Consultant |
| Rivers Cuomo | Songs |
| Snoop Dogg | Songs |
| Kenny G | Songs |
| J Balvin | Songs |
| Tyga | Songs |
| The Flaming Lips | Songs |
