 | Alexa PenaVega als Carmen Cortez |
 | Daryl Sabara als Juni Cortez |
 | Antonio Banderas als Gregorio Cortez |
 | Carla Gugino als Ingrid Cortez |
 | Alan Cumming als Fegan Floop |
 | Tony Shalhoub als Alexander Minion |
 | Teri Hatcher als Ms. Gradenko |
 | Robert Patrick als Mr. Lisp |
 | Dick Clark als Financier |
 | George Clooney als Devlin |
 | Cheech Marin als Felix Gumm |
 | Danny Trejo als Machete |
 | Richard Linklater als Cool Spy |
 | Mike Judge als Donnagon / Donnamight |
 | Guillermo Navarro als Pastor |
 | Johnny Reno als Agent Johnny |
| Shannon Shea als FoOglie #1/Flower |
| Kara Slack als Carmen's Friend |
 | Jeffrey J. Dashnaw als Brat's Dad |
 | Norman Cabrera als FoOglie #2 / Tall & Skinny |
| Trant Batey als FoOglie #3 / Too Too |
| Bob Weinstein | Executive Producer |
| Cary Granat | Executive Producer |
| Robert Rodriguez | Director |
| Robert Rodriguez | Producer |
| Elizabeth Avellan | Producer |
| Harvey Weinstein | Executive Producer |
| Guillermo Navarro | Director of Photography |
| Robert Rodriguez | Editor |
| Ed Vega | Art Direction |
| Jeanette Scott | Set Decoration |
| Bill Scott | Line Producer |
| Anne McCarthy | Casting |
| Alex Newman | Casting Associate |
| Mary Vernieu | Casting |
| Danny Elfman | Original Music Composer |
| Robert Rodriguez | Sound Re-Recording Mixer |
| Robert Rodriguez | Visual Effects Supervisor |
| Daniel Leduc | Visual Effects Supervisor |
| John McLeod | Special Effects Coordinator |
| Danny Elfman | Songs |
| Anna Abbey | Set Costumer |
| Gala Autumn | Costume Supervisor |
| Robert Rodriguez | Camera Operator |
| Freddy Luis | Casting Associate |
| Tamara Smith | Co-Producer |
| Howard Berger | Makeup Effects |
| Michael Semanick | Sound Re-Recording Mixer |
| Cary White | Production Design |
| Bill Scott | Unit Production Manager |
| Ronn Basquette | Set Designer |
| Stephanie Lowry | Music Editor |
| John Debney | Original Music Composer |
| Robert Kurtzman | Makeup Effects |
| Marc Baird | Storyboard |
| Robert Rodriguez | Original Music Composer |
| Nina Proctor | Costume Supervisor |
| Gina Grande | Script Supervisor |
| Cynthia Streit | Production Coordinator |
| Robert Rodriguez | Writer |
| Troy Breeding | Key Hair Stylist |
| Patrushkha Mierzwa | Boom Operator |
| Greg Nicotero | Makeup Effects |
| Michael J. Sullivan | Assistant Art Director |
| Helen Griffiths | Casting Associate |
| Ermahn Ospina | Makeup Artist |
| Deborah Everton | Costume Design |
| Greg Hedgepath | Supervising Sound Editor |
| Edmund J. Lachmann | Dialogue Editor |
| Cynthia Morris | First Assistant Editor |
| Jo Edna Boldin | Local Casting |
| Gwendolyn Yates Whittle | ADR Supervisor |
| Rico Torres | Still Photographer |
| Heitor Pereira | Additional Music |
| Harry Gregson-Williams | Original Music Composer |
| Beth Sepko | Extras Casting |
| David McGill | Camera Operator |
| Julie Feiner | Dialogue Editor |
| Steve Joyner | Property Master |
| Mark Choi | ADR Editor |
| David McGill | Steadicam Operator |
| Heitor Pereira | Original Music Composer |
| Robin Lynn Bonaccorsi | Stunts |
| Troy Gilbert | Stunts |
| Troy Robinson | Stunts |
| Troy Brown | Stunts |
| Steve M. Davison | Stunts |
| Jeffrey J. Dashnaw | Stunt Coordinator |
| Buddy Joe Hooker | Stunts |
| Erik Rondell | Stunts |
| Katie Boggs | Stunts |
| Tony Lee Boggs | Stunts |
| Doc D. Charbonneau | Stunts |
| Jake Dashnaw | Stunts |
| Rachel Duhame | Stunts |
| Dino Dos Santos | Stunt Double |
| Donna Evans | Stunts |
| Kanan Hooker | Stunts |
| Houston Hooker | Stunts |
| Tommy J. Huff | Stunts |
| Thomas J. Larsen | Stunts |
| Cinda-Lin James | Stunts |
| Jeff Schwan | Stunts |
| Charles A. Tamburro | Stunts |
| Natalie Nooner | Stunts |
| Joe Bucaro III | Stunts |
| Lucinda Hinton | Stunts |
| Lin Oeding | Stunts |
