 | Julianne Moore als Alice Howland |
 | Kate Bosworth als Anna Howland-Jones |
 | Shane McRae als Charlie Howland-Jones |
 | Hunter Parrish als Tom Howland |
 | Alec Baldwin als John Howland |
 | Seth Gilliam als Frederic Johnson |
 | Kristen Stewart als Lydia Howland |
 | Stephen Kunken als Dr. Benjamin |
 | Erin Darke als Jenny |
 | Daniel Gerroll als Eric Wellman |
 | Quincy Tyler Bernstine als Nursing Home Administrator |
 | Maxine Prescott als Nursing Home Resident |
 | Orlagh Cassidy als Primary Care Doctor |
 | Rosa Arredondo als Convention Facilitator |
 | Zillah Glory als Masha (Three Sisters) |
 | Caridad Montanez als Elena |
| Caleb Freundlich als Young Musician |
| Charlotte Robson als Young Musician |
| Jean Burns als Olga (Three Sisters) (uncredited) |
 | José Báez als Head Waiter (uncredited) |
 | Victoria Cartagena als Prof. Hooper (uncredited) |
| Jeannette Gould als Alzheimer's Patient (uncredited) |
 | Takako Haywood als Alzheimer's Conference Attendee (uncredited) |
| Samantha Kelly als TV Reporter (uncredited) |
| Diane Kimbrell als Alzheimer's Patient (uncredited) |
| Cat Lynch als Pinkberry Worker (uncredited) |
| Joanne Perica als Crying Woman (uncredited) |
| Jamie Lee Petronis als Pinkberry Worker (uncredited) |
| Nancy Ellen Shore als Nurse (uncredited) |
 | Eha Urbsalu als Alice's Mother (uncredited) |
| Gail Yudain als Meeting Attendee (uncredited) |
| Wash Westmoreland | Director |
| Richard Glatzer | Director |
| Lisa Genova | Novel |
| Wash Westmoreland | Screenplay |
| Richard Glatzer | Screenplay |
| Allison Estrin | Casting |
| Denis Lenoir | Director of Photography |
| Kerry Barden | Casting |
| Tommaso Ortino | Production Design |
| Paul Schnee | Casting |
| Nicolas Chaudeurge | Editor |
| Stacey Battat | Costume Design |
| Ilan Eshkeri | Original Music Composer |
| Pamela Koffler | Producer |
| Lex Lutzus | Producer |
| James Brown | Producer |
| Anton Gold | Sound Mixer |
| Jacqueline Weiss | Key Hair Stylist |
| Stephen McLaughlin | Music Producer |
| Matthias Gohl | Music Producer |
| Andrew Brown | Musician |
| Kelly Reichardt | Thanks |
| Marie Savare | Executive Producer |
| Christine Vachon | Executive Producer |
| Maria Shriver | Executive Producer |
| Celine Rattray | Executive Producer |
| Trudie Styler | Executive Producer |
| Emilie Georges | Executive Producer |
| Nicholas Shumaker | Executive Producer |
| Jean-Baptiste Babin | Executive Producer |
| David Atlan Jackson | Executive Producer |
| Joel Thibout | Executive Producer |
| Declan Baldwin | Co-Producer |
| Elizabeth Gelfand Stearns | Co-Producer |
| Randall Poster | Music Supervisor |
| Meghan Currier | Music Supervisor |
| Declan Baldwin | Unit Production Manager |
| Chris Carroll | First Assistant Director |
| Derek Wimble | Second Assistant Director |
| Lynn Appelle | Line Producer |
| Lynn Appelle | Unit Production Manager |
| Catherine Farrell | Post Production Supervisor |
| Michele Baker | Location Manager |
| Susan Perlman | Set Decoration |
| Megan Sanders | Wardrobe Supervisor |
| James Baker | Location Sound Mixer |
| Brien Sauchelli | Key Grip |
| Karl Hartman | Production Coordinator |
| Susan Reilly LeHane | Makeup Department Head |
| Jeong-Hwa Fonkalsrud | Key Makeup Artist |
| Kimberly Braisin | Key Makeup Artist |
| Mandy Lyons | Hair Department Head |
| Andrea Ulrich | Script Supervisor |
| Javier Bennassar | Supervising Sound Editor |
| Ruy García | Sound Effects Editor |
| Debora Lilavois | Music Editor |
| Josine Cohen | Music Coordinator |
| Tony Kushner | Thanks |
| Steven Pinker | Thanks |
| Todd Haynes | Thanks |
| Anton Chekhov | Thanks |
| Duncan Heath | Thanks |
| Caroline Arnoul | Thanks |
| Maria E. Garcia | Tailor |
