 | Darren Criss als Kal-El / Clark Kent / Superman (voice) |
 | Zachary Quinto als Lex Luthor (voice) |
 | Ike Amadi als J'onn J'onzz / Martian Manhunter (voice) |
 | Eugene Byrd als Ron Troupe (voice) |
 | David Chen als Med Student / Scientist (voice) |
 | Alexandra Daddario als Lois Lane (voice) |
 | Brett Dalton als Parasite / Rudy Jones (voice) |
 | Neil Flynn als Jonathan Kent (voice) |
 | Ryan Hurst als Lobo (voice) |
 | Cissy Jones als Nurse (voice) |
 | Piotr Michael als Perry White (voice) |
 | Cristina Milizia als Maya / Petey / Kaylie (voice) |
 | April Stewart als Mrs. Ross (voice) |
 | Bellamy Young als Martha Kent (voice) |
| Jerry Siegel | Characters |
| Joe Shuster | Characters |
| Chris Palmer | Director |
| Butch Lukic | Supervising Producer |
| Robert Hargreaves | Sound Designer |
| Wes Gleason | Sound Director |
| Sam Register | Executive Producer |
| Tim Sheridan | Screenplay |
| James Krieg | Producer |
| Kimberly S. Moreau | Producer |
| Bruce King | Editor |
| Wes Gleason | Casting |
| Kevin Riepl | Original Music Composer |
| Joe Samachson | Characters |
| Joe Certa | Characters |
| Jerry Ordway | Characters |
| Tom Grummett | Characters |
| Keith Giffen | Characters |
| Roger Slifer | Characters |
| Angela O'Sullivan | Line Producer |
| Marlene Corpuz | Production Manager |
| Lauren D. Sanchez | Assistant Production Manager |
| Alicia Heraper | Assistant Production Manager |
| Dusty Abell | Character Designer |
| Dou Hong | Character Designer |
| Otto Schmidt | Character Designer |
| Jon Suzuki | Character Designer |
| Kazuyoshi Takeuchi | Supervising Animation Director |
| Kohei Kenmotsu | Line Producer |
| Seigo Kitazawa | Animation Director |
| Yuji Watanabe | Animation Director |
| Greg Emerson | Other |
| Kip Brown | Post Producer |
| Brittany Canasi | Post-Production Manager |
| Jeff O. Collins | Other |
| Mark A. Keatts | Supervising Dialogue Editor |
| Mark A. Keatts | ADR Editor |
| David M. Cowan | Dialogue Editor |
| David M. Cowan | ADR Editor |
| Kelly Ann Foley | Dialogue Editor |
| Kelly Ann Foley | ADR Editor |
| Patrick J. Foley | Dialogue Editor |
| Patrick J. Foley | ADR Editor |
| Michael Garcia | ADR Editor |
| Michael Garcia | Dialogue Editor |
| Darren Griffiths | Online Editor |
| Frances E. Chang | Administration |
| Liz Carroll | Administration |
| Jake Baumgart | Legal Services |
| Bobbie Page | Production Supervisor |
| Ed Adams | Production Manager |
| Peter Girardi | Executive In Charge Of Production |
| Brian E.S. Jones | Executive In Charge Of Production |
