 | Nathan Lane als Spot Helperman / Scott Leadready II / Scott Manly-Manning (voice) |
 | Kelsey Grammer als Dr. Ivan Krank (voice) |
 | Shaun Fleming als Leonard Amadeus Helperman (voice) |
 | Debra Jo Rupp als Mrs. Mary Lou Moira Angela Darling Helperman (voice) |
 | David Ogden Stiers als Mr. Jolly (voice) |
 | Jerry Stiller als Pretty Boy (voice) |
 | Paul Reubens als Dennis (voice) |
 | Megan Mullally als Adele (voice) |
 | Wallace Shawn als Principal Crosby Strickler (voice) |
 | Rob Paulsen als Ian Wazselewski (voice) |
 | Jay Thomas als Barry Anger (voice) |
 | Estelle Harris als Mrs. Boogin (voice) |
 | Genie Francis als Marsha / Marcia (voice) |
 | Anthony Geary als John / Juan (voice) |
 | Rosalyn Landor als The Blue Fairy (voice) |
 | David Maples als Beefeater (voice) |
 | Pamela Adlon als Trevor / Taylor / Tyler (voice) |
 | Timothy Stack als Father (voice) |
| Emma Steinkellner als Little Girl (voice) |
 | Ken Swofford als Officer White (voice) |
 | Lauren Tom als Younghee (voice) |
 | Mae Whitman als Leslie Dunkling (voice) |
 | Kevin Michael Richardson als Conductor (voice) |
| Stephen Swofford | Producer |
| Bill Steinkellner | Screenplay |
| Cherie Steinkellner | Screenplay |
| Gary Baseman | Executive Producer |
| Bill Steinkellner | Executive Producer |
| Cherie Steinkellner | Executive Producer |
| Stephen James Taylor | Original Music Composer |
| Jamie Thomason | Casting |
| Gary Baseman | Art Direction |
| Timothy Bjorklund | Director |
| Randy Petersen | Songs |
| Christy Carlson Romano | Theme Song Performance |
| Kevin Quinn | Songs |
| Cherie Steinkellner | Songs |
| Brian Woodbury | Songs |
| Peter Lurye | Songs |
| Nancy Frazen | Supervising Film Editor |
| Ronald Eng | Sound Editor |
| Christina Long | Assistant Art Director |
| Michael Karafilis | Line Producer |
| Melinda Carrilla | Associate Producer |
| Timothy Bjorklund | Storyboard Artist |
| Chuck Klein | Storyboard Artist |
| Tina Kügler | Storyboard Artist |
| Fred Gonzales | Storyboard Artist |
| Zac Moncrief | Storyboard Artist |
| Celia Kendrick | Storyboard Artist |
| Melissa Suber | Storyboard Artist |
| Alfred Gimeno | Storyboard Artist |
| Ennio Torresan Jr. | Storyboard Artist |
| Kim Roberson | Character Designer |
| Billiam Coronel | Additional Writing |
| Jim Fisher | Additional Writing |
| David Maples | Additional Writing |
| Jim Staahl | Additional Writing |
| Jess Winfield | Additional Writing |
