 | Chloë Grace Moretz als Cassiopeia "Cassie" Sullivan |
 | Nick Robinson als Ben "Zombie" Parish |
 | Ron Livingston als Oliver Sullivan |
 | Maggie Siff als Lisa Sullivan |
 | Alex Roe als Evan Walker |
 | Maria Bello als Sergeant Reznik |
 | Maika Monroe als Marika "Ringer" Kimura |
 | Zackary Arthur als Sammy "Nugget" Sullivan |
 | Liev Schreiber als Lieutenant Colonel Alexander Vosch |
 | Tony Revolori als Dumbo |
 | Talitha Bateman als Allison / "Teacup" |
 | Nadji Jeter als Poundcake |
 | Alex MacNicoll als Flintstone |
 | Matthew Zuk als Wounded Man with Crucifix |
 | Gabriela Lopez als Lizbeth Morgan |
 | Bailey Anne Borders als Julia |
 | David Maldonado als Soccer Coach |
 | Paul Ryden als TV News Anchor |
 | E. Roger Mitchell als White House Spokesman |
 | Charmin Lee als Ms. Paulson |
 | Parker Wierling als Jeremy |
 | Madison Staines als Teary School Kid |
 | Terry Serpico als Hutchfield |
 | Derek Roberts als Private Parker |
 | Geoffrey Kennedy als Bullhorn Soldier |
 | Devin McGee als Confused Man |
 | Justin Matthew Smith als Armed Man |
| Jim Sutton als Soldier Calling Numbers |
 | Adora Dei als Exam Room Tech |
 | Kevin L. Johnson als Sniper in Woods |
| Cade Canon Ball als Kenny / "Oompa" |
 | Flynn McHugh als Tank |
 | Courtney Munch als Helicopter Soldier |
 | Kendrick Cross als Situation Room Soldier |
| Chelsea Hayes als Tech Soldier |
 | Michael Beasley als Major Bob |
| Olivia Cloer als Captured Teen (uncredited) |
 | Kelly Róisín als Quarantine Victim (uncredited) |
 | Johnny Otto als Dr. Osborne (uncredited) |
| Tobey Maguire | Producer |
| Susannah Grant | Screenplay |
| Graham King | Producer |
| Travis Pates | Makeup Artist |
| J Blakeson | Director |
| Rick Yancey | Novel |
| Francine Maisler | Casting |
| Jon Billington | Production Design |
| Paul Rubell | Editor |
| Chase Paris | Casting |
| Rendell Bryce | Set Costumer |
| Chuck Zlotnick | Still Photographer |
| Shawn Broes | Visual Effects Editor |
| Elizabeth Robinson | Key Hair Stylist |
| Tara Feldstein Bennett | Casting |
| Art Schultz | Rigging Gaffer |
| Richard King | Supervising Sound Editor |
| David Alonzo | Digital Intermediate |
| Jennifer R. Blair | Art Department Coordinator |
| Karina Benesh | Visual Effects Coordinator |
| Jeff Crumbley | Camera Operator |
| Crisanta Melendez | Visual Effects Coordinator |
| Michael Gowen | Assistant Art Director |
| Myra N. Foy | Seamstress |
| Diana Stulic Ibanez | Visual Effects Producer |
| Lisa Love | Makeup Department Head |
| Carrie Richardson | Visual Effects Producer |
| Scott Stokdyk | Visual Effects Supervisor |
| Alex Portin | Digital Intermediate |
| Neishaw Ali | Visual Effects Producer |
| Jeff Campbell | Visual Effects Supervisor |
| R.J. Kizer | ADR & Dubbing |
| Richard King | Sound Re-Recording Mixer |
| Ryan Andersen | Visual Effects Editor |
| Bryan Godwin | Visual Effects Supervisor |
| Gail Hunter | Script Supervisor |
| Dan Cornwall | Gaffer |
| Mike Fay | Visual Effects Editor |
| Jodie Stern | Assistant Costume Designer |
| Sean Schur | CG Supervisor |
| Christopher Flick | Foley |
| Suzanna Boykin | Hairstylist |
| Tom Kramer | Music Editor |
| Patrick Longman | Helicopter Camera |
| Jacquelyn Racine | Visual Effects Coordinator |
| Anna-Lena Carl | Visual Effects Coordinator |
| Julian Ashby | Supervising Art Director |
| Robert John Dubiel | Script Coordinator |
| Brandon Terry | Visual Effects Editor |
| Rick Owens | Foley |
| Enrique Chediak | Director of Photography |
| Patrick Zentis | Visual Effects Art Director |
| Jinnie Pak | Visual Effects Producer |
| Leslie Webb | First Assistant Editor |
| Charlene Amateau | Costume Supervisor |
| Ashley Marie Parker | Set Costumer |
| Brett Madill | Visual Effects Coordinator |
| Gregory D. Liegey | Visual Effects Supervisor |
| Anji Bemben | Hair Department Head |
| John McAlary | Casting Associate |
| Darren Poe | Visual Effects Supervisor |
| Michele Lewis | Makeup Artist |
| Richard Middleton | Executive Producer |
| Matthew Plouffe | Producer |
| Akiva Goldsman | Screenplay |
| Henry Jackman | Original Music Composer |
| Jeff Pinkner | Screenplay |
| Chris Lowenstein | Line Producer |
| Lynn Harris | Producer |
| Glenn Kaplan | First Assistant Camera |
| Shawn M. Gray | Armorer |
| Fred Thomas | First Assistant Camera |
| Hugo Weng | Dialogue Editor |
| Denis O'Sullivan | Executive Producer |
| Ben Waisbren | Executive Producer |
| Stephanie Little | Painter |
| Lauren Mary Kim | Stunts |
| Jimmy N. Roberts | Stunt Driver |
| Jasi Cotton Lanier | Stunts |
| Zack Duhame | Stunt Double |
| Karin Justman | Stunts |
| Joe Greenberg | Visual Effects Coordinator |
| David Waters | Second Assistant Director |
| Mathew Dunne | First Assistant Director |
| Jacob Garcia | Stunt Double |
| Ashleigh Dejon | Stunt Double |
| Nicolas Bosc | Stunt Double |
| Joey Box | Stunt Coordinator |
| Emily Brobst | Stunt Double |
| Daniel Arrias | Utility Stunts |
| Crystal Hooks | Stunts |
| Paul Lacovara | Stunts |
| Samuel Le | Stunts |
| Sarah Molasky | Stunt Double |
| Jane Oshita | Stunts |
| T. Ryan Mooney | Stunts |
| Susan Purkhiser | Stunts |
| Marvin Ross | Stunt Double |
| Eric Salas | Utility Stunts |
| Jade Quon | Stunts |
| Eric VanArsdale | Stunts |
| Terry Jackson | Stunts |
| Isaac Hughes | Stunts |
| Loyd Bateman | Stunts |
