 | Ryan Reynolds als Adam Reed |
 | Walker Scobell als Young Adam |
 | Mark Ruffalo als Louis Reed |
 | Jennifer Garner als Ellie Reed |
 | Zoe Saldana als Laura |
 | Catherine Keener als Maya Sorian |
 | Alex Mallari Jr. als Christos |
 | Braxton Bjerken als Ray Dollarhyde |
 | Kasra Wong als Chuck |
 | Lucie Guest als Young Sorian Body Double |
 | Donald Sales als Paul the Bartender |
 | Esther Ming Li als Sophie |
 | Ben Wilkinson als Derek |
 | Milo Shandel als Professor |
 | Isaiah Haegert als 8-year-old Adam |
| Josh McLaglen | Executive Producer |
| Tobias A. Schliessler | Director of Photography |
| Shawn Levy | Director |
| Shawn Levy | Producer |
| Claude Paré | Production Design |
| Ryan Reynolds | Producer |
| Helen Jarvis | Supervising Art Director |
| Elizabeth Wilcox | Set Decoration |
| Dana Goldberg | Producer |
| Carmen Cuba | Casting |
| Dean Zimmerman | Editor |
| Don Granger | Producer |
| Mary McLaglen | Executive Producer |
| David Ellison | Producer |
| Jennifer Flackett | Screenplay |
| Jennifer Flackett | Executive Producer |
| Mark Levin | Screenplay |
| Mark Levin | Executive Producer |
| Chris Beach | Art Direction |
| Jon Corn | Editor |
| Jenny Eagan | Costume Design |
| Rob Simonsen | Original Music Composer |
| Vivian Baker | Makeup Artist |
| Anji Bemben | Hair Department Head |
| Daniel S. Levine | Executive Producer |
| T.S. Nowlin | Screenplay |
| Jonathan Tropper | Writer |
| Craig Henighan | Supervising Sound Editor |
| Craig Henighan | Sound Re-Recording Mixer |
| Mark Paterson | Sound Re-Recording Mixer |
| Angelo Palazzo | Sound Designer |
| William Groebe | Storyboard Artist |
| Andre Brouwer | Costume Supervisor |
| Nick Dudar | Assistant Art Director |
| Blaine Lougheed | Visual Effects Supervisor |
| John Dale | Construction Coordinator |
| Alex Ongaro | Visual Effects Supervisor |
| Dan Cohen | Executive Producer |
| Andrew Lee McConnell | Assistant Art Director |
| Scott Balkcom | VFX Artist |
| Mike Duffy | Visual Effects Producer |
| Alexander Seaman | Visual Effects Supervisor |
| Katharina Brand | Set Dresser |
| Craig Humphries | Art Direction |
| Carmen Tse | Assistant Makeup Artist |
| Michael T. Marlett | VFX Editor |
| Janice Swayze | Costume Supervisor |
| Andrea Brown | Extras Casting |
| Alex Kyshkovych | Stunt Coordinator |
| Alex Kyshkovych | Stunt Double |
| George Dewey | Executive Producer |
| Jonathan Alan Abbott | Set Designer |
| Alexandros Isidorou | Other |
| Tom Katinic | Picture Car Coordinator |
| Patrick Gooing | Executive Producer |
| Eli Best | Art Direction |
| Ange Turchet | Compositing Artist |
| Alexander T.H. Browne | Visual Effects |
| Nick Nocera | Art Direction |
| Osama Gharib | Graphic Designer |
| Mike Mitchell | Stunt Coordinator |
