 | Johnny Depp als Commander Spencer Armacost |
 | Charlize Theron als Jillian Armacost |
 | Joe Morton als Sherman Reese |
 | Clea DuVall als Nan |
 | Nick Cassavetes als Captain Alex Streck |
 | Donna Murphy als Natalie Streck |
 | Gary Grubbs als NASA Director |
 | Blair Brown als Shelly McLaren |
 | Tom Noonan als Jackson McLaren |
 | Tom O'Brien als Allen Dodge |
 | Lucy Lin als Shelly Carter |
| Michael Crider als Pat Elliott |
 | Samantha Eggar als Dr. Patraba |
 | Rondi Reed als Dr. Conlin |
 | Conrad Bachmann als Reporter |
 | Sarah Dampf als Paula, 2nd Grade Student |
 | Charles Lanyer als Spencer's Doctor |
 | Gary Carlos Cervantes als Doctor |
 | Seth Barrish als Yuppie Shark |
| Ellen Lancaster als Dried Up Socialite |
| Julian Barnes als Waiter |
| Priscilla Shanks als Woman |
| Jennifer Burry als Second Woman |
 | Susan Cella als Third Woman |
 | Linda Powell als Fourth Woman |
 | Elston Ridgle als Security Guard |
 | Robert Sella als Maitre D' |
 | Samantha Carpel als Reporter (Video) |
| Stephen Berger als Doorman |
| Michael Luceri als Waiter at Party |
 | Ben Van Bergen als Storage Facility Client |
 | Edward Kerr als Pilot |
 | Cole Sprouse als Twin |
 | Dylan Sprouse als Twin |
 | Carl Burrows als Businessman (uncredited) |
 | Buck Holland als Mission Control (uncredited) |
| Jacob Stein als Calvin, 2nd Grade Student |
| Leslie A. Pope | Set Decoration |
| Sarah Knowles | Art Direction |
| Allen Daviau | Director of Photography |
| Rand Ravich | Director |
| George S. Clinton | Original Music Composer |
| Isis Mussenden | Costume Design |
| Rand Ravich | Screenplay |
| Jan Roelfs | Production Design |
| Debi Manwiller | Casting |
| Andrew Lazar | Producer |
| Richard Pagano | Casting |
| Deborah K. Larsen | Makeup Department Head |
| Patti McNulty | Art Department Coordinator |
| Peter Boynton | Lighting Technician |
| Tom Fleischman | Sound Re-Recording Mixer |
| Gregory C. Tippie | Special Effects Coordinator |
| Ann Miller | Set Costumer |
| Guy Adan | Unit Publicist |
| Paul C. Babin | Camera Operator |
| Wendy Cox | Production Supervisor |
| Brent Haywood | Construction Coordinator |
| John 'D.J.' Des Jardin | Visual Effects Supervisor |
| Linda Drake | Visual Effects Supervisor |
| Josh R. Jaggars | Visual Effects Producer |
| Amy Jo Hoppenfeld | Set Costumer |
| Blake Leyh | Supervising Sound Editor |
| Larry McConkey | Steadicam Operator |
| Craig Fehrman | Transportation Coordinator |
| Tim A. Davison | Stunt Coordinator |
| Robert Earl Craft | Location Manager |
| Randall D. Wilkins | Set Designer |
| Guy T. Wiedmann | Visual Effects Editor |
| Sean Garnhart | Sound Effects Editor |
| Deborah Parker | Location Manager |
| David Katz | Video Assist Operator |
| Joe Ondrejko | Construction Coordinator |
| Russell R. Anderson | Leadman |
| Mike Flicker | Music Editor |
| Marion Tumen | Script Supervisor |
| Karl J. Martin | Set Designer |
| JoAnn Fregalette Jansen | Choreographer |
| Steve Mirkovich | Editor |
| Matthew Haasch | Foley Mixer |
| Marko Costanzo | Foley Artist |
| Paul Urmson | Foley Editor |
| Hal Levinsohn | ADR Editor |
| Michael Barosky | Sound Mixer |
| Kimberly R. McCord-Wilson | Dialogue Editor |
| David H. Allen | Property Master |
| Timothy Alverson | Editor |
| Jay Peck | Foley Artist |
| K.C. Colwell | First Assistant Director |
| Larry Wallace | Chief Lighting Technician |
| Reggie Newkirk | First Assistant Camera |
| Faye Sevilla | Wardrobe Coordinator |
| Scott Giegler | 3D Animator |
| Derek Spears | Digital Compositor |
| Allen Ruilova | Visual Effects Technical Director |
| Susan Kowarsh | Assistant Costume Designer |
| Jeff W. Smith | Digital Compositor |
| Chris Scarfi | Generator Operator |
| Johanna Pizzo | Contact Lens Technician |
| Roseann Milano | Wardrobe Supervisor |
| Jeff Wolverton | Visual Effects Technical Director |
| Christopher Casey | Set Dresser |
| Greg Etheredge | Electrician |
| Tony Olivieri | First Assistant Camera |
| William Moore | Gaffer |
| Paul Gibilisco | Second Assistant Camera |
| Bela Brozsek | 3D Animator |
| Serkan Zelzele | Digital Compositor |
| Michael Lyon | Best Boy Electric |
| Barbara Preser | Assistant Costume Designer |
| Ross Richardson | Electrician |
| A. Lee Morris | Second Assistant Camera |
| Steve LaVietes | Visual Effects Technical Director |
| Bennie Zura | Electrician |
| Michael Kenner | Key Grip |
| David Dunbar | Rigging Gaffer |
| Jennifer Apel | Assistant Editor |
| Thomas R. Homsher | Special Effects Coordinator |
| R. Adam Chambers | Electrician |
| Tim Metivier | Second Assistant Camera |
| Sondra James | ADR Voice Casting |
| Michael Lantieri | Special Effects Supervisor |
| Tia Schellstede | Assistant Editor |
| Patty York | Makeup Artist |
| Candy L. Walken | Hair Department Head |
| Mike Gerzevitz | Electrician |
| Juan Morse | Electrician |
| Patrick Zentis | Digital Compositor |
| Seth Lippman | Visual Effects Technical Director |
| Chris Rosen | Electrician |
| Eyde Belasco | Casting Associate |
| Marc Rubone | Digital Compositor |
| Sheena Duggal | Special Effects |
| Mary Funsten | Camera Loader |
| Alexandria Forster | Costume Supervisor |
| Matt Boatright-Simon | Editorial Staff |
| John DeSimone | Production Coordinator |
| Gregory Dunigan | Production Secretary |
| Bob McMillian | Color Timer |
| William Yeh | Assistant Editor |
| Leon Dudevoir | Production Executive |
| Mato | Color Timer |
| Jon Davidson | Production Accountant |
| Dina Farnell | Production Coordinator |
| Michael Healey | Colorist |
| Dana Hee | Stunts |
| Troy Robinson | Stunts |
| Jody Hedien | Associate Producer |
| Diana Pokorny | Co-Producer |
| Mark Johnson | Executive Producer |
| Donna Langley | Executive Producer |
| Brian Witten | Executive Producer |
| Rick Lalonde | Special Effects Makeup Artist |
| Rick Reynolds | Post Production Supervisor |
| Mari-Jo Winkler | Unit Production Manager |
| Paula Case | Second Second Assistant Director |
| Darin Rivetti | Second Assistant Director |
| Christine Mayer | Assistant Set Decoration |
| Chris Samp | Set Painter |
| Chris Fielder | Assistant Sound Editor |
| Frank Kern | Sound Editor |
| Paul Ledford | Production Sound Mixer |
| Bill Orrico | Apprentice Sound Editor |
| Keenan Wyatt | Boom Operator |
| Jerry Yuen | Utility Sound |
| Eric Allard | Special Props |
| Jeffrey P. Buccacio Jr. | Sculptor |
| Jonathan Spence | Animatronics Designer |
| Lee Berger | Executive Visual Effects Producer |
| Randy Brown | Visual Effects Compositor |
| Mitch Deoudes | Visual Effects |
| Harry Lam | Digital Supervisor |
| Nancy Young | Stunt Double |
| Quinn Grove | Grip |
| Buck Allen | Location Scout |
| Michael Boriskin | Music Consultant |
| Paul Broucek | Music Supervisor |
| Rick Giovinazzo | Orchestrator |
| Annie Searles | Music Coordinator |
| John Carrington | Musician |
| David Conelli | Driver |
| Knut Kielpinski | Production Driver |
| Walter McClain | Transportation Captain |
| Monica Barraza | Production Assistant |
| Cyndi Brenner | Assistant Production Coordinator |
| Jeff Chena | Stand In |
| Timothy Donohue | Set Production Assistant |
| Arik Johnson | Payroll Accountant |
| Zane | Post Production Accountant |
| Jeffrey J. Dashnaw | Stunts |
| Jimmy N. Roberts | Stunts |
| Erik Rondell | Stunts |
