 | John Goodman als Babe Ruth |
 | Kelly McGillis als Claire Ruth |
 | Trini Alvarado als Helen Ruth |
 | Randy Steinmeyer als Ty Cobb |
 | James Cromwell als Brother Mathias |
 | Michael McGrady als Lou Gehrig |
 | Richard Tyson als Guy Bush |
 | Joseph Ragno als Miller Huggins |
 | Ralph Marrero als Frank 'Ping' Bodie |
 | Bernard Kates als Colonel Jack Ruppert |
 | Stevie Lee als Eddie the Bat Boy |
 | Bruce Boxleitner als Jumpin' Joe Dugan |
 | Peter Donat als Frazee |
 | J.C. Quinn als Jack Dunn |
 | Robert Swan als George Ruth Sr. |
 | Stephen Caffrey als Johnny Sylvester (at 30) |
 | Danny Goldring als Bill Carrigan |
 | Bernie Gigliotti als Al Capone |
 | Michael Nicolosi als Jimmy Colosimmo |
 | W. Earl Brown als Herb Pennock |
 | Shannon Cochran als Flapper |
 | Michael Papajohn als Heckler |
 | Gene Weygandt als Mr. Sylvester |
 | Brendan Hutt als Boy at St. Mary's |
| Jeffrey Wiseman als Boy at St. Mary's |
 | Elizabeth Greenberg als Dorothy Ruth |
 | Larry Cedar als Forbes Field Announcer |
 | Alan Johnson als Orphanage Reporter |
 | Michael Krawic als Theatre-Goer |
 | Johanna McKay als Yankee Wife |
 | Jim Ortlieb als Scribe |
 | Scott Haven als Scribe |
 | Tricia Munford als Ida Dugan, Jump's Wife |
 | Matt Doherty als Boy in Car |
| Arthur Hiller | Director |
| John Fusco | Producer |
| John Fusco | Screenplay |
| Elmer Bernstein | Music |
| Haskell Wexler | Director of Photography |
| Robert C. Jones | Editor |
| Valerie McCaffrey | Casting |
| Nancy Nayor | Casting |
| James Dowell Vance | Production Design |
| Gary Baugh | Art Direction |
| Leslie Bloom | Set Decoration |
| April Ferry | Costume Design |
| Werner Sherer | Hairstylist |
| John S. Robertson | Key Grip |
| Walter Coblenz | Executive Producer |
| Bill Finnegan | Executive Producer |
| Erica Hiller | Associate Producer |
| Jim Van Wyck | Co-Producer |
| Art Anthony | Key Makeup Artist |
| E. Thomas Case | Key Makeup Artist |
| Deborah K. Dee | Key Hair Stylist |
| Kevin Haney | Makeup Artist |
| Werner Sherer | Hair Supervisor |
| Jamie Sue Weiss | Makeup Artist |
| Peter Bankins | Property Master |
| Linda Buchanan | Set Designer |
| Karen Fletcher Trujillo | Set Designer |
| Samuel W. Gailey | Art Department Production Assistant |
| Michael Merritt | Set Designer |
| J. Christopher Phillips | Set Designer |
| Tony Gardner | Special Props |
| Stu Bernstein | Sound Editor |
| Robert Bradshaw | Sound Editor |
| Richard Burton | Sound Editor |
| Larry Carow | Sound Editor |
| Todd Egan | Assistant Sound Editor |
| Hector C. Gika | Sound Editor |
| Marilyn Graf | Foley Recordist |
| Leslie Gaulin | Foley Editor |
| Glenn Hoskinson | Sound Editor |
| Holly Huckins | ADR Editor |
| John Kwiatkowski | Sound Editor |
| Mary Jo Lang | Foley Mixer |
| John Leveque | Supervising Sound Editor |
| Dennis Maitland | Production Sound Mixer |
| Anthony Milch | Sound Editor |
| Rocky Moriana Jr. | Sound Editor |
| Michele Perrone | ADR Editor |
| John Roesch | Foley Artist |
| Katie Rowe | Foley Artist |
| Steve Schwalbe | Foley Editor |
| Mary Ruth Smith | Sound Editor |
| Bruce Stambler | Supervising Sound Editor |
| James S. Stewart | Sound Recordist |
| Shawn Sykora | Foley Editor |
| Donald L. Warner Jr. | Sound Editor |
| Rickley W. Dumm | Assistant Sound Editor |
| Steve Richardson | Sound Editor |
| Carolyn Tapp | Foley Recordist |
| Richard E. Yawn | Sound Editor |
| John D. Milinac | Special Effects Coordinator |
| Chuck Comisky | Visual Effects Supervisor |
| Michele Ferrone | Visual Effects Producer |
| Linda Perlin | Stunts |
| G. A. Aguilar | Stunts |
