 | Jason Bateman als Dave Lockwood |
 | Ryan Reynolds als Mitch Planko |
 | Leslie Mann als Jamie Lockwood |
 | Olivia Wilde als Sabrina McArdle |
 | Alan Arkin als Mitch's Dad |
 | Gregory Itzin als Flemming Steel |
 | Mircea Monroe als Tatiana |
 | Sydney Rouviere als Cara Lockwood |
 | Matthew Cornwell als Parks Foreman |
 | Craig Bierko als Valtan |
 | TJ Hassan als Kinkabe Lawyer |
 | Ned Schmidtke als Ted Norton |
 | Ming Lo als Ken Kinkabe |
 | Dax Griffin als Blow-Dried Goon |
 | Andrea Moore als Sophia |
 | Taaffe O'Connell als Mona |
 | Bailey Anne Borders als Babysitter |
 | Clay Chamberlin als Boom Operator |
 | Jeanine Jackson als Carla Nelson |
 | Fred Stoller als Movie Set PA |
| Jamie Renell als Lawyer |
 | Kenny Alfonso als Businessman at Sonsie Café |
 | Joe Knezevich als Amalgamated Exec |
| Matthew Stanton als PA |
| Gabe Wood als Neighbor |
 | Ed Ackerman als Victor |
 | Vickie Eng als Erin Walsh |
| Amber Seyer als Beautiful Woman |
 | Anna Colwell als Cute Girl in Elevator |
| Steven Dean Davis als Tattoo Artist |
| Suzanne Arkin als Pamela |
 | Patricia French als Dave's Secretary |
 | Jeanette Miller als Grandma Taylor |
 | Greg Savage als Construction Worker |
 | Adam Boyer als Tattoo Artist |
 | Matthew Rimmer als Tattoo Artist |
| Ken DeLozier als Minister |
| Paul Barlow Jr. als Amalgamated Attorney |
 | Anthony G Breed als Amalgamated Attorney |
| Gary Babiarz als Amalgamated Attorney |
 | Dimitrius Pulido als Greased Up Lorno Guy |
 | Blake Goza als 1st AD |
 | Arin Logan als Sexy Girl in Bar |
 | Martha B. Knighton als Old Lady |
 | Michael Beasley als Security Guard |
| Clay Edmund Kraski als Security Guard |
| Courtney Amis als Teen #2 (uncredited) |
 | India Batson als Teen #1 (uncredited) |
 | Nadej K. Bailey als Student (uncredited) |
| Holly Britt als Pretzel Stand Customer (uncredited) |
| Orlando Vargas Diaz als Attorney (uncredited) |
| Bradford Haynes als Dad (uncredited) |
| Josiah Lyricq als Shopper (uncredited) |
| Todd Maynor als Recital Parent (uncredited) |
 | Miles Mussenden als Attorney (uncredited) |
 | Anna Rappaport als Firefly Girl (uncredited) |
 | Steven Reddington als Parks Dept. Employee (uncredited) |
| Joel Rogers als Businessman (uncredited) |
| Joshua Tanksley als Valet (uncredited) |
 | Lesley E. Warren als Amalgamated Attorney (uncredited) |
| Gloria Webber als Business Woman (uncredited) |
| Jon Lucas | Screenplay |
| David Dobkin | Director |
| Scott Moore | Screenplay |
| David Dobkin | Producer |
| Barry Robison | Production Design |
| Thomas Minton | Art Direction |
| Seth Kleinberg | Visual Effects Producer |
| Pablo Borges | Assistant Costume Designer |
| Miracole Burns | Set Costumer |
| Debra Schutt | Set Decoration |
| Greg Hayden | Editor |
| Betsy Heimann | Costume Design |
| Jeff Passanante | Construction Coordinator |
| Sarah Downer | Set Costumer |
| Sarah Katzman | Casting |
| Joe Digaetano | Special Effects Coordinator |
| Beth Lipari | Casting Associate |
| Rhonney Greene | Set Costumer |
| Neal H. Moritz | Producer |
| Eric Alan Edwards | Director of Photography |
| Lee Haxall | Editor |
| David Jones | Visual Effects Supervisor |
| Autumn Saville | Assistant Costume Designer |
| Gail Hunter | Script Supervisor |
| Amy Lehman | Art Department Coordinator |
| Anthony Hays | Visual Effects Coordinator |
| Jonathan Clay Harris | Casting Associate |
| Joyce Kogut | Costume Supervisor |
| Tara Feldstein Bennett | Casting Associate |
| John Debney | Music |
| Sally Wilkerson | Set Costumer |
| Lisa Beach | Casting |
| Cylinda Nesmith Davison | Seamstress |
| Rod Ortega | Hair Department Head |
| Natasha Ladek | Wigmaker |
| Elaine L. Offers | Makeup Department Head |
| Mary Anne Spano | Makeup Artist |
| Gianna Sparacino | Key Hair Stylist |
| Amy Tagliamonti | Makeup Artist |
| Ian Gracie | Supervising Art Director |
| Kevin Kaska | Orchestrator |
| Michael A. Martinez | Visual Effects |
| Chris LeDoux | Visual Effects Supervisor |
| John Brubaker | Visual Effects |
| Ori Marmur | Executive Producer |
| Chris Coyne | Location Scout |
| Matt Aberle | Music Supervisor |
| Brian Bulman | Music Editor |
| Andrew Silver | Music Editor |
| Gretel Twombly | Production Coordinator |
| Thomas R. Polleri | Location Scout |
| Robin F. Samson | Location Scout |
| Joseph M. Caracciolo Jr. | Executive Producer |
| Jann K. Engel | Set Designer |
| Jeff Kleeman | Executive Producer |
| Marco Rubeo | Set Designer |
| Maria T. Bierniak | Location Manager |
| Jonathon Komack Martin | Executive Producer |
| Frank Cuomo | Post Production Supervisor |
| Ellen Gannon | Production Coordinator |
| Dana Robin | Unit Production Manager |
| Jeff Carson | Music Editor |
| Thomas S. Drescher | Music Editor |
| Kai Thorup | Location Scout |
| Mike Watts | Orchestrator |
| Jack Gill | Second Unit Director |
| Jack Gill | Stunt Coordinator |
| Ashley Rae Trisler | Stunts |
