 | Eric Stoltz als Martin Brundle |
 | Daphne Zuniga als Beth Logan |
 | Lee Richardson als Anton Bartok |
 | John Getz als Stathis Borans |
 | Frank C. Turner als Shepard |
 | Ann Marie Lee als Dr. Jainway |
 | Garry Chalk als Scorby |
 | Saffron Henderson als Ronnie |
 | Harley Cross als 10 year old Martin |
| Matthew Moore als 4 year old Martin |
| Rob Roy als Wiley |
| Andrew Rhodes als Hargis |
 | Pat Bermel als Mackenzie |
 | William S. Taylor als Dr. Trimble |
 | Jerry Wasserman als Simms |
 | Robert Metcalfe als Observer #1 |
 | Garwin Sanford als Observer #2 |
 | Bruce Harwood als Technician |
 | Lorena Gale als Woman |
 | Bill Dow als Man |
 | Duncan Fraser als Obstetrician |
 | Ken Camroux-Taylor als Linder |
 | Tom Heaton als Manager |
 | Allan Lysell als Guard 'A' |
 | Suzanne Ristic als Guard #1 |
| Danny Virtue als Guard #2 |
 | Mike Winlaw als Neonatologist |
| Kimelly Anne Warren als Maria |
| David Mylrea als Flywalker |
| Cecilia Warren als Anchorwoman |
| Andrea Mann als Cute Girl |
| Sterling Cottingham als Baby Martin/Newborn |
| Rodney Clough Jr. als Martin Brundle - 1 1 / 2 years old |
 | Jeff Goldblum als Seth Brundle (archive footage) (uncredited) |
| Chris Walas | Director |
| Steven-Charles Jaffe | Producer |
| Jim Wheat | Screenplay |
| Ken Wheat | Screenplay |
| Frank Darabont | Screenplay |
| Christopher Young | Music |
| Robin Vidgeon | Director of Photography |
| Sean Barton | Editor |
| Mick Garris | Screenplay |
| Deborah Lucchesi | Casting |
| Christopher Ryan | Costume Design |
| Michael S. Bolton | Production Design |
| Sandy Cochrane | Art Direction |
| Rose Marie McSherry | Set Decoration |
| Sherry Linder-Gygli | Hairstylist |
| Jayne Dancose | Makeup Artist |
| Thom Wells | Construction Coordinator |
| Glen W. Pearson | Assistant Art Director |
| Steve Craine | Lead Painter |
| Avo Liva | Greensman |
| James H. Chow | Property Master |
| Patrick Dodd | ADR & Dubbing |
| Leslie Shatz | Sound Designer |
| Ralph Wikke | Sound Effects Editor |
| Patrick Dodd | Dialogue Editor |
| Danny Kopelson | Sound Re-Recording Mixer |
| David Parker | Sound Re-Recording Mixer |
| Katherine Kean | Animation |
| January Nordman | Animation |
| Joseph Thomas | Animation |
| John T. Van Vliet | Animation |
| John Wardlow | Stunt Coordinator |
| John Clothier | Steadicam Operator |
| Joseph Lederer | Still Photographer |
| Stephen Jackson | Gaffer |
| Richard Buckmaster | Rigging Gaffer |
| Michelle Allen | Casting |
| Jay Ignaszewski | First Assistant Editor |
| Michael Smith | First Assistant Editor |
| Earl Ghaffari | Music Editor |
| Jay Ignaszewski | Music Editor |
| Jean Bereziuk | Script Supervisor |
| Tracey Jeffrey | Location Manager |
| Steve Newman | Unit Publicist |
| Cyrus Block | Camera Operator |
| Chris Walas | Effects Supervisor |
| Stuart Cornfeld | Executive Producer |
| John Watson | Assistant Editor |
| George Langelaan | Characters |
| Mick Garris | Story |
| Stephan Dupuis | Special Effects Makeup Artist |
| Dennis Pawlik | Special Effects Makeup Artist |
| Jo-Anne Smith-Ojeil | Special Effects Makeup Artist |
| Sydney Silvert | Assistant Makeup Artist |
| Brenda Turner | Assistant Hairstylist |
| Gillian Richardson | Associate Producer |
| Richard Coleman | Second Assistant Director |
| Peter D. Marshall | First Assistant Director |
| Kenna Marshall-Pittman | Third Assistant Director |
| Peter Talbot | Assistant Director Trainee |
| Mel Brooks | Producer |
