 | Chris Pratt als Peter Quill / Star-Lord |
 | Dave Bautista als Drax |
 | Karen Gillan als Nebula |
 | Pom Klementieff als Mantis |
 | Vin Diesel als Groot (voice) |
 | Bradley Cooper als Rocket (voice) |
 | Sean Gunn als Kraglin |
 | Rhett Miller als Bzermikitokolok |
 | Murry Hammond als Alien Band (Kortolbookalia) |
 | Ken Bethea als Alien Band (Sliyavastojoo) |
 | Philip Peeples als Alien Band (Phloko) |
 | Michael Rooker als Yondu |
 | Kevin Bacon als Kevin Bacon |
 | Luke Klein als Young Peter Quill |
 | Maria Bakalova als Cosmo the Dog (voice) |
 | Kyra Sedgwick als Kyra Sedgwick (voice) |
 | Si Chen als Sobbing Woman |
 | Don McLeod als Statue Guy |
| Thomas McNamara als 'Captain America' |
 | Daniel Bernhardt als Gobot |
| Michelle Gunn als Tourist Mom |
 | Flula Borg als Bartender |
| Matthew Withers als Handsome Man |
 | Rusty Schwimmer als Sara |
| Helene D'Auria als Dispatcher (voice) |
 | Tinashe Kajese als Officer Fitzgibbon |
| Barry Curtis als Officer R. Bobbitt |
 | Rachel Luttrell als Upside-Down Cop |
 | Giovannie Cruz als Orloni Peddler |
 | Stephen Blackehart als Steemie |
 | Sarah Alami als Gloob |
 | Terence Rosemore als Gurb |
| Troy Beecham als Drunken Knowherean (uncredited) |
| James Gunn | Director |
| James Gunn | Writer |
| Henry Braham | Director of Photography |
| Beth Mickle | Production Design |
| Rosemary Brandenburg | Set Decoration |
| Alexei Dmitriew | Makeup Department Head |
| Greg D'Auria | Editor |
| Kevin Feige | Executive Producer |
| Louis D'Esposito | Executive Producer |
| Victoria Alonso | Executive Producer |
| Brad Winderbaum | Executive Producer |
| James Gunn | Executive Producer |
| Sara Smith | Executive Producer |
| Simon Hatt | Executive Producer |
| David J. Grant | Co-Producer |
| Lars P. Winther | Co-Producer |
| Dave Jordan | Music Supervisor |
| Trygge Toven | Music Supervisor |
| John Murphy | Original Music Composer |
| Susan Pickett | Visual Effects Producer |
| Bryan Searing | Visual Effects Producer |
| Stephane Ceretti | Visual Effects Supervisor |
| Judianna Makovsky | Costume Design |
| Gregg Featherman | Editor |
| Nik Korda | Line Producer |
| Sarah Halley Finn | Casting |
| Nadia Paine | Unit Production Manager |
| Nik Korda | Unit Production Manager |
| Lars P. Winther | First Assistant Director |
| Amir R. Khan | Second Assistant Director |
| Liz Marston | Sound Re-Recording Mixer |
| Steve Slanec | Supervising Sound Editor |
| Coya Elliott | Supervising Sound Editor |
| Anele Onyekwere | Supervising Music Editor |
| Anele Onyekwere | Other |
| Sarah Halley Finn | Consulting Producer |
| Heidi Moneymaker | Stunt Coordinator |
| Wayne Dalglish | Stunt Coordinator |
| Hank Amos | Stunt Coordinator |
| Gary Peebles | Stunt Double |
| Ellette Craddock | Stunt Double |
| Colin Follenweider | Stunt Double |
| Thomas Watson | Stunt Double |
| Sadiqua Bynum | Stunt Double |
| Randall Archer | Stunt Double |
| Daniel Bernhardt | Stunts |
| Niahlah Hope | Stunts |
| Clay Chamberlin | Stand In |
| Jared Leland Gore | Stand In |
| Briana LaChelle Lantz | Stand In |
| Clementyne Vega | Stand In |
| Darin Sahler | Stand In |
| David E. Scott | Supervising Art Director |
| Alan Hook | Supervising Art Director |
| Alex McCarroll | Art Direction |
| Lorin Flemming | Art Direction |
| Sam Avila | Art Direction |
| Brittany Hites | Art Direction |
| Zach Fannin | Art Direction |
| Kat Rich | Assistant Art Director |
| Laura Cox | Assistant Art Director |
| Molly Hunter Flick | Art Department Coordinator |
| Kelly Hemenway | Graphic Designer |
| Mary Shriner | Graphic Designer |
| Caitlin MacGregor | Art Department Production Assistant |
| Erin Morrell | Art Department Production Assistant |
| Molly Scott | Art Department Production Assistant |
| Christopher TJ McGuire | "B" Camera Operator |
| Thomas Lappin | "C" Camera Operator |
| Dermot Hickey | First Assistant "A" Camera |
| Brian Greenway | First Assistant "B" Camera |
| Max Junquera | First Assistant "C" Camera |
| Bess Johnson | Second Assistant "A" Camera |
| Bill McConnell Jr. | Second Assistant "B" Camera |
| Jessica Miglio | Still Photographer |
| Nastasia Humphries | Camera Loader |
| Ryan Meinerding | Visual Development |
| Patrick Dunn-Baker | Set Designer |
| Vincent Bates | Set Designer |
| Nick S. Cross | Set Designer |
| Tim Croshaw | Set Designer |
| Kristen Jenkins | Set Designer |
| Silvia Mahapatra | Set Designer |
| Daniela Medeiros | Set Designer |
| Anne Porter | Set Designer |
| Joseph Ramiro | Set Designer |
| Marco Rubeo | Set Designer |
| Chris Sanford | Set Designer |
| Ed Symon | Set Designer |
| Justin Trudeau | Set Designer |
| Kevin Vickery | Set Designer |
| Haisu Wang | Set Designer |
| Chris L. Ward | Set Designer |
| Robert Woodruff | Set Designer |
| Reigh Casimir | Post Production Supervisor |
| Jennifer Bergman | Post Production Supervisor |
| Basuki Juwono | First Assistant Editor |
| Todd Busch | First Assistant Editor |
| Daniel Boccoli | First Assistant Editor |
| Alex Scratch | Other |
| Jenny Lindamood | Other |
| Rick Ives | Other |
| Andrea Nieto | Other |
| Madeline O'Hara | Post Production Coordinator |
| Andrew Ross | Post Production Coordinator |
| Kosta Saric | VFX Editor |
| Robert Drwila | VFX Editor |
| Tyler Whitman | VFX Editor |
| Michael J. Wechsler | VFX Editor |
| Zeke Morales | VFX Editor |
| Dominick Rolandelli | Visual Effects Assistant Editor |
| Ivan Moutinho | Visual Effects Assistant Editor |
| Sebastian Rico | Editorial Production Assistant |
| Emily Kim | Editorial Production Assistant |
| Robb Boyd | Music Editor |
| Elizabeth Mogayzel | Production Assistant |
| Matt Watson | Colorist |
| Justin Ramer | Visual Effects Coordinator |
| Patrick King-Templeton | Visual Effects Coordinator |
| Katrissa 'Kat' Peterson | Visual Effects Production Manager |
| Tom Carson | Production Supervisor |
| Lisa Joelle Curtis | Production Coordinator |
| Alli Sheahan | Assistant Production Coordinator |
| Joel Wells | Assistant Production Coordinator |
| Jackson Giles | Travel Coordinator |
| Yul Brynner | Production Secretary |
| Kera Dacy | Script Supervisor |
| Ryan J. Pezdirc | Second Second Assistant Director |
| Arielle DePace | Second Second Assistant Director |
| Brendan Finnigan | Production Controller |
| Sonia Y. Dawson | Production Accountant |
| Michele Wright | First Assistant Accountant |
| Cynthia Young | First Assistant Accountant |
| Daniella LaGraff | Accountant |
| Malcolm Campbell | Second Assistant Accountant |
| Anita Jackson | Second Assistant Accountant |
| Stephen Workman | Second Assistant Accountant |
| Elizabeth Oh | Second Assistant Accountant |
| Lauren Michele Reed | Second Assistant Accountant |
| Jamie Lee | Second Assistant Accountant |
| Tucker Holt | Second Assistant Accountant |
| Ben Mendiola | Payroll Accountant |
| Justin Kratzer | Payroll Accountant |
| Russell Bobbitt | Property Master |
| Daniel Sudick | Special Effects Supervisor |
| Lee Orloff | Sound Mixer |
| Jeffrey A. Humphreys | Boom Operator |
| Kurt Kornemann | Key Grip |
| Ian Easterbrook | Location Manager |
| John M. 'Jack' Wright | Costume Supervisor |
| Michelle Moon | Assistant Costume Designer |
| Shanna Knecht | Assistant Costume Designer |
| Annie Davis | Location Coordinator |
| Cassie Russek | Hair Department Head |
| Stephanie Fenner | Key Hair Stylist |
| Jessica Nelson | Contact Lens Painter |
| Denise Adams | Contact Lens Technician |
| Amber Shani Hamilton | Hairstylist |
| Monique Hyman | Hairstylist |
| Dawn Turner | Hairstylist |
| LuAndra Whitehurst | Key Makeup Artist |
| Scott Stoddard | Key Makeup Artist |
| Mo Meinhart | Key Makeup Artist |
| Chase Paris | Local Casting |
| Tara Feldstein Bennett | Local Casting |
| Elizabeth Driscoll | Unit Publicist |
| Jeremy Emerman | Epk Producer |
| Jennifer Hamilton | Other |
| Jillian Henry | Executive Assistant |
| Brianna DaSilveira | Executive Assistant |
| Nick Wingate | Executive Assistant |
| Candice Horde | Executive Assistant |
| Natasha Walford | Executive Producer's Assistant |
| Taylor Brown | Producer's Assistant |
| Samina Martens | Executive Producer's Assistant |
| Alex Cherry | Executive Assistant |
| Mindy Weissman | Actor's Assistant |
| Jared Shaw | Other |
| Patricia Quinata | Chef |
| Amanda Painito | Assistant Chef |
| Ericka Bonilla | Actor's Assistant |
| Michaela Hudson | Actor's Assistant |
| Andy Johnson | Actor's Assistant |
| Tammy L. Smith | Extras Casting |
| Ciara Nolley | Extras Casting Assistant |
| Dashia Wathen | Extras Casting Assistant |
| Rachel Nadler | Casting Associate |
| Molly Doyle | Casting Associate |
| Sage Ross | Casting Assistant |
| Tasha Ward | Casting Assistant |
| Adylene Villanueva | Executive Assistant |
| Courtney Baker | Production Manager |
| Courtney Baker | Development Manager |
| Phi Hiro Lam | Chef |
| Reginald Smith | Craft Service |
| Jim Starlin | Characters |
| Stan Lee | Characters |
| Larry Lieber | Characters |
| Jack Kirby | Characters |
| Steve Englehart | Characters |
| Don Heck | Characters |
| Roger Stern | Characters |
| John Buscema | Characters |
| Sal Buscema | Characters |
| Bill Mantlo | Characters |
| Keith Giffen | Characters |
| Steve Gan | Characters |
| Dan Abnett | Thanks |
| Wellinton Alves | Thanks |
| Gene Colan | Thanks |
| Marko Djurdjevic | Thanks |
| Arnold Drake | Thanks |
| Mike Friedrich | Thanks |
| Timothy Green II | Thanks |
| Andy Lanning | Thanks |
| Paul Pelletier | Thanks |
| Lee Gunn | Thanks |
| Jennifer Holland | Thanks |
| Kristen B. Adams | Assistant Art Director |
| James Edward Tilden | Second Second Assistant Director |
| Renae Moneymaker | Stunt Coordinator |
| Kevin R. Wright | Other |
