 | Ben Stiller als Eddie Cantrow |
 | Malin Åkerman als Lila |
 | Michelle Monaghan als Miranda |
 | Jerry Stiller als Doc |
 | Rob Corddry als Mac |
 | Mae LaBorde als Cute Elderly Couple Diner |
 | Carlos Mencia als Tito |
 | Scott Wilson als Boo |
 | Polly Holliday als Beryl |
 | Danny McBride als Martin |
 | Roy Jenkins als Buzz |
 | Stephanie Courtney als Gayla |
 | Natalie Carter als 10 Year Old Girl |
 | Nicol Paone als Esperanza Hotel Bar Patron |
 | Miranda May als Tourist Daughter |
 | Kathy Lamkin als Lila's Mom |
 | Dean Norris als Jodi's Father |
 | Leslie Easterbrook als Jodi's Mom |
 | Eva Longoria als Consuela |
 | Jackie Flynn als Beach Shack Customer |
| Gary Riotto als Wedding Coordinator |
 | Mitch Rouse als Bicycle Mugger |
 | Kayla Kleevage als Busty Woman in Hot Tub |
| Kenny Santiago Marrero als Wedding Dancer / Guest (uncredited) |
 | Kevin J. Flynn als Flamboyant Man |
| Apple Farrelly als Kid At Wedding Table (as Apple Kocsis) |
 | Amy Sloan als Deborah |
| Jerry Sherman als Grandpa Anderson |
 | Lauren Bowles als Tammy |
| Bobby Farrelly | Director |
| Peter Farrelly | Director |
| Kevin Barnett | Screenplay |
| Leslie Dixon | Screenplay |
| Bobby Farrelly | Screenplay |
| Ted Field | Producer |
| Matthew F. Leonetti | Director of Photography |
| Alan Baumgarten | Editor |
| Scot Armstrong | Screenplay |
| Sabine Varnes | Stunts |
| Peter Farrelly | Screenplay |
| Bradley Thomas | Producer |
| John Davis | Executive Producer |
| Brendan Ryan | Music |
| Bill Ryan | Music |
| Sam Seig | Editor |
| Scott Wilder | Stunts |
| Neil Simon | Original Film Writer |
| Mark Charpentier | Co-Producer |
| Marc S. Fischer | Executive Producer |
| Tony Lord | Co-Producer |
| Kris Meyer | Co-Producer |
| Ellen Dumouchel | Associate Producer |
| Matt Weaver | Co-Producer |
| Hal Olofsson | Associate Producer |
| Charles B. Wessler | Executive Producer |
| Rick Montgomery | Casting |
| Joseph Middleton | Casting |
| Arlan Jay Vetter | Production Design |
| Sydney J. Bartholomew Jr. | Production Design |
| Cindy Carr | Set Decoration |
| Stephanie J. Gordon | Art Direction |
| Louise Mingenbach | Costume Design |
| J.B. Rogers | Second Unit Director |
| Hal Olofsson | First Assistant Director |
| Greg Guzik | Second Assistant Director |
| Mark R. Byers | Special Effects Coordinator |
| William H. Burton Jr. | Stunts |
| Corey Michael Eubanks | Stunts |
| Jonathan Arthur | Stunt Double |
| Gina Mari | Stunts |
| Ed McDermott II | Stunt Driver |
| Greg Fitzpatrick | Stunt Double |
| Gary Price | Stunts |
| Betsy Rue | Stunts |
| Stephen W. Schriver | Stunts |
| Frank Torres | Stunts |
| Michael Trisler | Stunts |
| Antonio Todd | Stunts |
| Dain Turner | Stunts |
| Tierre Turner | Stunt Coordinator |
| Gene Hartline | Stunt Driver |
| Hugo Cortina | Second Unit Director of Photography |
| Steve Gehrke | Script Supervisor |
