 | Adrien Brody als Jack Starks |
 | Keira Knightley als Jackie Price |
 | Kris Kristofferson als Dr. Thomas Becker |
 | Jennifer Jason Leigh als Dr. Beth Lorenson |
 | Kelly Lynch als Jean Price |
 | Brad Renfro als The Stranger |
 | Daniel Craig als Rudy Mackenzie |
 | Angel Coulby als Intern #2 |
 | Steven Mackintosh als Dr. Hopkins |
 | Brendan Coyle als Damon |
 | Mackenzie Phillips als Nurse Harding |
 | Laura Marano als Young Jackie |
 | Jason Lewis als Officer Harrison |
 | Richard Dillane als Captain Medley |
 | Jonah Lotan als Intern #1 |
 | Nigel Whitmey als Lieutenant |
 | Ian Porter als Major |
 | Angus MacInnes als Judge |
 | Richard Durden als Dr. Hale |
 | Tristan Gemmill als Officer Nash |
 | Colin Stinton als Jury Foreman |
 | Tara Summers als Nurse Nina |
 | Anthony Edridge als Dr. Morgan (as Antony Edridge) |
 | Teresa Gallagher als Nurse Sally |
 | Paul Birchard als Doctor |
 | Kerry Shale als Prosecutor |
| Angelo Andreou als Babak/Iraqi Boy |
 | Anne Kidd als State Representative |
| Charneh Demir als Jamile/Iraqi Mother |
| Frances Brady-Stewart als Woman with Dog |
| Lolly Susi als Nurse |
 | Garrick Hagon als Defense Lawyer |
 | Fish als Jimmy Fleisher |
| John Maybury | Director |
| George Clooney | Producer |
| Ben Cosgrove | Executive Producer |
| Mark Cuban | Executive Producer |
| Jennifer Fox | Executive Producer |
| Andreas Grosch | Executive Producer |
| Peter Guber | Producer |
| Ori Marmur | Executive Producer |
| Timothy J. Nicholas | Executive Producer |
| Christopher Roberts | Executive Producer |
| Steven Soderbergh | Producer |
| Peter E. Strauss | Executive Producer |
| Todd Wagner | Executive Producer |
| Peter Deming | Director of Photography |
| Emma E. Hickox | Editor |
| Brian Eno | Original Music Composer |
| Laray Mayfield | Casting |
| Sylvain Bernier | Gaffer |
| Bernard April | Best Boy Electric |
| Roger Tooley | Steadicam Operator |
| Marc Rocco | Co-Producer |
| Marc Frydman | Co-Producer |
| Philip McKeon | Co-Producer |
| Donald C. McKeon | Co-Producer |
| Andreas Schmid | Co-Producer |
| Kia Jam | Co-Producer |
| Peter McAleese | Co-Executive Producer |
| Alan MacDonald | Production Design |
| Nina Gold | Casting |
| Doug Hall | Costume Design |
| Massy Tadjedin | Screenplay |
| Tom Bleecker | Story |
| Marc Rocco | Story |
| Shellie Smith | Production Supervisor |
| Karen Richards | First Assistant Director |
| Raymond Kirk | Second Assistant Director |
| Lloret Dunn | Location Manager |
| Mags Horspool | Supervising Art Director |
| George Lakes | Production Controller |
| Colin Nicolson | Production Sound Mixer |
| Veronica McAleer | Hair Designer |
| Veronica McAleer | Makeup Designer |
| Caroline O'Reilly | Script Supervisor |
| Andy Bradford | Stunt Coordinator |
| David McKeown | Stunt Coordinator |
| David Harris | Special Effects Supervisor |
| Paul Davies | Supervising Sound Editor |
| Paul Davies | Sound Designer |
| Jeanette Haley | Post Production Supervisor |
| Donald Sabourin | Production Coordinator |
| Tony Cook | Boom Operator |
| Julie Adams | Dialect Coach |
| Linda Gamble | Unit Publicist |
| Paul Chedlow | Still Photographer |
| Anna Lau | Costume Supervisor |
| Heather Millington | Makeup Artist |
| Ashley Johnson | Makeup Artist |
| Caireen Todd | Art Direction |
| Stephen Campbell | Art Direction |
| Liz Griffiths | Set Decoration |
| Gordon Fitzgerald | Property Master |
| Andy Richards | Music Supervisor |
| Michael Higham | Music Editor |
| Jay Benedict | ADR Voice Casting |
| Phoebe Scholfield | ADR Voice Casting |
| Keith Marriner | Dialogue Editor |
| Keith Marriner | ADR Editor |
| Alex Joseph | Foley Editor |
| Tim Alban | Sound Re-Recording Mixer |
| Matt Curtis | Title Designer |
| Peter Burgis | Foley Artist |
| Ricky Butt | Foley Artist |
| Tahira Herold | Hairstylist |
| Louis Craig | Special Effects |
| Patrick Kerton | Stunts |
| Charles Jarman | Stunts |
| Bruce Cain | Stunt Double |
| Colin Nicolson | Sound Mixer |
