 | Charlize Theron als Dr. Wren Petersen |
 | Javier Bardem als Dr. Miguel Leon |
 | Jean Reno als Dr. Mehmet Love |
 | Adèle Exarchopoulos als Ellen |
 | Jared Harris als Dr. Farber |
 | Hopper Penn als Billy Boggs |
 | Denise Newman als Sarie |
 | Mark De Villiers als Wren's Father |
| Amy Harries-Jones als Young Wren |
| Obed Baloyi als Atef |
 | Merritt Wever als Marlee |
| Vaneshran Arumugam als East Indian UN Staffer |
 | Tinarie Van Wyk-Loots als UN Staffer |
| Sebelethu Bonkolo als Sam |
 | Sibongile Mlambo als Assatu |
 | Bill Gerber als UN Representative |
 | Bronwyn Reed als Catholic School Girl |
| Chris Gxalaba als Oom Pieter |
| Fiona Ramsay als Beatrice |
| Sarah Muhoho als Sierra Leone Villager |
| Linda Sokhulu als Triage Nurse |
 | Ebby Weyime als Nurse |
| Andile Vuyolwethu Pakade als Youth Soldier |
 | Elodie Venece als Priya |
| Oscar Best als Dr. Brown |
| Erin Dignam | Screenplay |
| Bill Pohlad | Producer |
| Matt Palmieri | Producer |
| Sean Penn | Director |
| Bill Gerber | Producer |
| Jay Cassidy | Editor |
| Hans Zimmer | Original Music Composer |
| Andrew Laws | Production Design |
| Barry Ackroyd | Director of Photography |
| Diana Cilliers | Costume Design |
| Kristine Berg | Ager/Dyer |
| Donavin Waters | Pyrotechnician |
| Nancy Parker | Foley |
| Brian Wentzel | Armorer |
| Didier Lozahic | Sound Re-Recording Mixer |
| Cordell McQueen | Special Effects Supervisor |
| Andrea Leanza | Prosthetic Makeup Artist |
| Michael Hyman | Art Direction |
| Jason Howey | CG Supervisor |
| Dave McMoyler | Supervising Sound Editor |
| Marli Kruger | Makeup Artist |
| Ken Hodgson | Key Grip |
| Paul Pieterse | Special Effects Coordinator |
| Alyson Dee Moore | Foley |
| Enzo Angileri | Hairstylist |
| Stefan Sonnenfeld | Digital Intermediate |
| John Gore | Drone Operator |
| Nick Jimenez | ADR & Dubbing |
| Anthony Bozanich | First Assistant Editor |
| Andrew Orlando | Art Direction |
| Gillian Florence | Costume Supervisor |
| Darrin Hofmeyr | CG Supervisor |
| Gaby Beyers | Art Department Coordinator |
| Michael Saal | Ager/Dyer |
| Nil Henchoz | Key Grip |
| Christian P. Minkler | Sound Re-Recording Mixer |
| Sven Vosloo | Additional Camera |
| Geoff Kock | ADR & Dubbing |
| Warren Shaw | Sound Designer |
| Jessica Veasey | Makeup Artist |
| Koketso Mbuli | Set Costumer |
| Helena Packer | Visual Effects Supervisor |
| George Webster | Visual Effects Supervisor |
| Jacques Jouffret | Steadicam Operator |
| Jason Martin | Underwater Camera |
| Adam Asmal | Epk Camera Operator |
| Jon Title | Sound Effects Editor |
| Richard Kitting | Sound Re-Recording Mixer |
| Clinton Smith | Prosthetic Designer |
| Darryl Hammer | Supervising Art Director |
| Marco Raposo de Barbosa | Visual Effects Supervisor |
| Massimo Gattabrusi | Hairstylist |
| Rick de Souza | Key Costumer |
| Joshua Spivack | Visual Effects Producer |
| George Loucas | Visual Effects Supervisor |
| John Ross | Sound Re-Recording Mixer |
| Kerry Skelton | Makeup Department Head |
| Joe Guzman | Digital Intermediate |
| Jane Tones | First Assistant Editor |
| Christa Schamberger | Casting |
| Terri Douglas | ADR Voice Casting |
| Jacques Pienaar | Boom Operator |
| Nadine Prigge | Makeup Designer |
| Grant Urquhart | Armorer |
| Els Owen | Makeup Artist |
| Paul Carlin | Digital Intermediate |
| Byron Tofas | Digital Compositor |
| Michelle Pazer | Dialogue Editor |
| Tom Olive | Set Decoration |
