 | Peter Cushing als Sherlock Holmes |
 | John Mills als Dr. John H. Watson / Narrator |
 | Anne Baxter als Irene Adler / Mrs. Norton |
 | Ray Milland als Home Secretary |
 | Anton Diffring als Graf Udo Von Felseck |
 | Gordon Jackson als Inspector Alec MacDonald |
 | Marcus Gilbert als Anton Von Felseck |
 | Susan Penhaligon als Miss Derwent |
 | Jenny Laird als Mrs. Hudson |
 | Russell Hunter als Alfred Coombs |
 | James Cossins als Frederick Bains |
 | Eric Dodson als Lord Claremont |
| Georgina Coombs als Lady Claremont |
| James Head als Chauffeur |
| Roy Ward Baker | Director |
| N.J. Crisp | Writer |
| Arthur Conan Doyle | Characters |
| Malcolm Williamson | Original Music Composer |
| Kevin Francis | Executive Producer |
| Roy Baker | Sound Editor |
| Mary Sturgess | Hairstylist |
| Geoffrey Tozer | Art Direction |
| Ernest Gasser | Makeup Artist |
| Otto Snel | Sound Re-Recording Mixer |
| Norman Priggen | Producer |
| Chris Barnes | Editor |
| Anthony Hinds | Screenstory |
| Brendan J. Stafford | Director of Photography |
| Roy Ashton | Makeup Artist |
| Clifton Brandon | Production Manager |
| Karen G. Wilson | Assistant Sound Editor |
| Anthony Mendleson | Costume Design |
| Mark Nelson | Hairstylist |
| Danny Daniel | Sound Recordist |
