 | Keanu Reeves als Neo |
 | Laurence Fishburne als Morpheus |
 | Carrie-Anne Moss als Trinity |
 | Hugo Weaving als Agent Smith |
 | Jada Pinkett Smith als Niobe |
 | Mary Alice als Oracle |
 | Harold Perrineau als Link |
 | Collin Chou als Seraph |
 | Harry Lennix als Commander Lock |
 | Ian Bliss als Bane |
 | Lambert Wilson als The Merovingian |
 | Bruce Spence als The Trainman |
 | Monica Bellucci als Persephone |
 | Nona Gaye als Zee |
 | Anthony Zerbe als Councillor Hamann |
 | Tanveer K. Atwal als Sati |
 | Helmut Bakaitis als The Architect |
 | Kate Beahan als Coat Check Girl |
| Francine Bell als Councillor Grace |
| Rachel Blackman als Charra |
| Henry Blasingame als Deus Ex Machina |
 | David Bowers als Q-Ball Gang Member #1 |
| Matt Castelli als Operations Officer Mattis |
 | Essie Davis als Maggie |
| Dion Horstmans als Q-Ball Gang Member #2 |
 | Lachy Hulme als Sparks |
 | Roy Jones Jr. als Captain Ballard |
 | Christopher Kirby als Mauser |
| Peter Lamb als Colt |
 | Nathaniel Lees als Mifune |
 | Robert Mammone als AK |
| Joe Manning als First Operator At Command |
 | Maurice Morgan als Tower Soldier |
| Tharini Mudaliar als Kamala |
 | Rene Naufahu als Zion Gate Operator |
 | Robyn Nevin als Councillor Dillard |
 | Genevieve O'Reilly als Officer Wirtz |
| Kittrick Redmond als Second Operator At Command |
 | Rupert Reid als Lock's Lieutenant |
 | Kevin Michael Richardson als Deus Ex Machina (voice) |
 | David Roberts als Roland |
 | Richard Sydenham als Dock Sergeant |
| Che Timmins als Radio Bunker Man |
 | Gina Torres als Cas |
 | Clayton Watson als Kid |
 | Cornel West als Councillor West |
 | Bernard White als Rama-Kandra |
 | Anthony Brandon Wong als Ghost |
 | Rick Shuster als Pilot (uncredited) |
| Don Davis | Original Music Composer |
| Lilly Wachowski | Director |
| Jules Cook | Art Direction |
| Owen Paterson | Production Design |
| Joel Silver | Producer |
| Kym Barrett | Costume Design |
| Lilly Wachowski | Screenplay |
| Catherine Mansill | Art Direction |
| Brian Dusting | Set Decoration |
| Mali Finn | Casting |
| Richard Adrian | Sound Designer |
| Shauna Wolifson | Casting |
| Deb Asch | Visual Effects |
| Steve Courtley | Special Effects |
| Ray Anthony | Stunts |
| Bill Pope | Director of Photography |
| Glenn Boswell | Stunts |
| Zach Staenberg | Editor |
| Lana Wachowski | Director |
| Lana Wachowski | Screenplay |
| Charlie Revai | Art Direction |
| Chuck Duke | Animation |
| James McTeigue | Assistant Director |
| Gregg Rudloff | Sound Re-Recording Mixer |
| Brice R. Parker | Visual Effects Coordinator |
| John 'D.J.' Des Jardin | Visual Effects Supervisor |
| David Lee | Sound Recordist |
| Brad Martin | Stunt Double |
| Brad Martin | Stunts |
| Marc Gabbana | Concept Artist |
| Yuen Woo-Ping | Fight Choreographer |
| Lilly Wachowski | Executive Producer |
| Lana Wachowski | Executive Producer |
| Grant Hill | Executive Producer |
| Andrew Mason | Executive Producer |
| Bruce Berman | Executive Producer |
| John Gaeta | Visual Effects Supervisor |
| Grant Hill | Unit Production Manager |
| James McTeigue | First Assistant Director |
| Claire Richardson | Second Assistant Director |
| Dane A. Davis | Sound Designer |
| Dane A. Davis | Supervising Sound Editor |
| Geofrey Darrow | Conceptual Design |
| Vicki Popplewell | Associate Producer |
| Steve Richards | Associate Producer |
| Glenn Boswell | Stunt Coordinator |
| Keir Beck | Stunts |
| Bob Bowles | Stunts |
| Danielle Burgio | Stunts |
| Marky Lee Campbell | Stunts |
| Raelene Chapman | Stunts |
| Harry Dakanalis | Stunts |
| Danial Donai | Stunts |
| Nash Edgerton | Stunts |
| Ousaun Elam | Stunts |
| Lou Horvath | Stunts |
| Graham Jahne | Stunts |
| Peter Jeremijenko | Stunts |
| Alex Kuzelicki | Stunts |
| Scott McLean | Stunts |
| Chris Mitchell | Stunts |
| Chris O'Hara | Stunts |
| Melanie Peyton-Smith | Stunts |
| Darrin Prescott | Stunts |
| Mick Roughan | Stunts |
| Warwick Sadler | Stunts |
| Yasca Sinigaglia | Stunts |
| Brit Sooby | Stunts |
| Gillian Statham | Stunts |
| Darko Tuscan | Stunts |
| Bernadette Van Gyen | Stunts |
| Aaron Walters | Stunts |
| Min Windle | Stunts |
| Hugh Bateup | Supervising Art Director |
| Philip Keller | Storyboard Artist |
| Simon Murton | Concept Artist |
| Darek Gogol | Concept Artist |
| Damien Drew | Assistant Art Director |
| Cindi Knapton | Assistant Art Director |
| Karen Murphy | Assistant Art Director |
| Michael Turner | Assistant Art Director |
| Godric Cole | Set Designer |
| Philip Thomas | Set Designer |
| Christian Huband | Set Designer |
| Victoria Sullivan | Script Supervisor |
| Gerry Nucifora | Boom Operator |
| John Bowring | Armorer |
| Peter Cogar | Armorer |
| Belinda Villani | Sculptor |
| Reg Garside | Gaffer |
| Mark Watson | Electrician |
| Ian Bird | Key Grip |
| Michael Vivian | Dolly Grip |
| Aron Walker | Dolly Grip |
| Jay Munro | Best Boy Grip |
| Martin Fargher | Grip |
| John Regan | Grip |
| Steve Courtley | Special Effects Supervisor |
| Peter Robb-King | Makeup Department Head |
| Deborah Taylor | Key Makeup Artist |
| Maggie Fung | Key Makeup Artist |
| Tina Gordon | Makeup Artist |
| Margaret Aston | Makeup Artist |
| Judith A. Cory | Hair Department Head |
| Dan Bronson | Costume Supervisor |
| Dan Glass | Visual Effects Supervisor |
| Terry Clotiaux | Visual Effects Producer |
| L. Dean Jones Jr. | Unit Production Manager |
| Jody Rogers | Visual Effects Editor |
| Jessica Alan | Post Production Supervisor |
| Julia Evershade | Supervising Sound Editor |
| Andrew Lackey | Sound Effects Designer |
| Andrew Lackey | Sound Effects Editor |
| Michael Edward Johnson | Sound Effects Editor |
| Mark Larry | Sound Effects Editor |
| Richard Adrian | Sound Effects Editor |
| Michael W. Mitchell | Sound Effects Editor |
| Paul Berolzheimer | Sound Effects Editor |
| Stephanie Flack | Supervising Dialogue Editor |
| Stephanie Brown | ADR Editor |
| Nancy Barker | First Assistant Sound Editor |
| Eryne Prine | Assistant Sound Editor |
| Paul Hackner | Assistant Sound Editor |
| Nathan Whitehead | Assistant Sound Editor |
| John Roesch | Foley Artist |
| Alyson Dee Moore | Foley Artist |
| Mary Jo Lang | Foley Mixer |
| David Jobe | Foley Mixer |
| Scott Morgan | Foley Recordist |
| Thomas J. O'Connell | ADR Mixer |
| Rick Canelli | ADR Recordist |
| Barbara Harris | ADR Voice Casting |
| John T. Reitz | Sound Re-Recording Mixer |
| David E. Campbell | Sound Re-Recording Mixer |
| Steve Pederson | Additional Sound Re-Recording Mixer |
| Armin Steiner | Scoring Mixer |
| Joe E. Rand | Music Editor |
| Zigmund Gron | Music Editor |
| Amanda Crittenden | Production Supervisor |
| Gerald Scaife | Production Supervisor |
| Jacqueline King | Production Coordinator |
| Peter Lawless | Location Manager |
| Henrie Stride | Extras Casting Assistant |
| Suzanne Celeste | Dialect Coach |
| Susan Hegarty | Dialect Coach |
| Fiona Searson | Unit Publicist |
| Ian Bickerton | Construction Foreman |
| Kimble Rendall | Second Unit Director |
| Ross Emery | Second Unit Director of Photography |
| Toby Pease | Second Unit First Assistant Director |
| Steven Boyle | Makeup Effects |
| Chad Stahelski | Stunt Coordinator |
| David Leitch | Stunts |
| Justin Folk | Visual Effects Assistant Editor |
| George Hull | Visual Effects Art Director |
