 | Sally Hawkins als Elisa Esposito |
 | Michael Shannon als Richard Strickland |
 | Richard Jenkins als Giles |
 | Octavia Spencer als Zelda Fuller |
 | Michael Stuhlbarg als Dr. Robert Hoffstetler |
 | Doug Jones als Amphibian Man |
 | David Hewlett als Fleming |
 | Nick Searcy als General Hoyt |
 | Stewart Arnott als Bernard |
 | Nigel Bennett als Mihalkov |
 | Lauren Lee Smith als Elaine Strickland |
 | Martin Roach als Brewster Fuller |
 | Allegra Fulton als Yolanda |
 | John Kapelos als Mr. Arzounian |
 | Morgan Kelly als Pie Guy |
 | Marvin Kaye als Burly Russian |
 | Dru Viergever als Military Policeman |
 | Wendy Lyon als Sally (Secretary) |
 | Cody Ray Thompson als Guard |
 | Diego Fuentes als Worker |
 | Madison Ferguson als Tammy Strickland |
 | Jayden Greig als Timmy Strickland |
 | Karen Glave als African American Wife |
 | Danny Waugh als African American Husband |
 | Dan Lett als Cadillac Salesman |
 | Deney Forrest als Lou |
 | Brandon McKnight als Duane |
 | Clyde Whitham als Wet Cinema Patron |
 | Jonelle Gunderson als Bus Passenger #1 |
 | Cameron Laurie als Bus Passenger #2 |
| Evgeny Akimov als Russian Band |
| Sergey Nikonov als Russian Band |
| Vanessa Oude-Reimerink als Russian Band |
| Alexey Pankratov als Russian Band |
| Shane Clinton Jarvis als Military Police (uncredited) |
| Dave Reachill als Scientist (uncredited) |
| Amanda Smith als Mrs. Peabody (uncredited) |
| Maxine Grossman als Bus Passenger (uncredited) |
| Greg Sigurdson | Other |
| Jean Frenette | Stunt Coordinator |
| David G. Fremlin | Assistant Art Director |
| Pierre Henry | Assistant Director |
| Dennis Berardi | Visual Effects Supervisor |
| Sidney Wolinsky | Editor |
| J. Miles Dale | Producer |
| David Best | Assistant Art Director |
| Guy Davis | Conceptual Design |
| Mary Juric | Assistant Editor |
| Paul D. Austerberry | Production Design |
| Luca Nemolato | Conceptual Design |
| Liz Sayre | Executive Producer |
| Guillermo del Toro | Producer |
| Shane Vieau | Set Decoration |
| Glen Gauthier | Sound Mixer |
| Lisa Shamata | Unit Publicist |
| Jordan Samuel | Makeup Department Head |
| John B. Harper | First Assistant Camera |
| Vanessa Taylor | Screenplay |
| Mike Hill | Sculptor |
| Luis Sequeira | Costume Design |
| Danny Haeberlin | Researcher |
| Samantha Dick | Assistant Art Director |
| Kristin Wayne | Makeup Artist |
| Evan Webber | Assistant Art Director |
| Jeff Vitkuske | Other |
| Marc Kuitenbrouwer | Construction Coordinator |
| Guillermo del Toro | Screenplay |
| Guillermo del Toro | Story |
| Guillermo del Toro | Director |
| Brad Zoern | Sound Re-Recording Mixer |
| Nathan Robitaille | Supervising Sound Editor |
| Jeffrey A. Melvin | Set Decoration |
| Christian T. Cooke | Sound Re-Recording Mixer |
| Sophie Giraud | Additional Still Photographer |
| Clifford J. Tasner | Orchestrator |
| Bruce McLean | Transportation Coordinator |
| Paula Fleet | Hair Designer |
| Tom Starnes | Gaffer |
| Ann Steel | Assistant Costume Designer |
| Sarah Riley | Digital Intermediate |
| Roberto Campanella | Choreographer |
| Chris Bacik | Drone Operator |
| Catherine Gilchrist | Casting Assistant |
| Rob Hegedus | Music Editor |
| Robert Johnson | Key Grip |
| Jonathan Oliveira | Casting Associate |
| Lisa Pagliaro | Seamstress |
| Jordan Worrell | Animal Wrangler |
| Dustin Harris | Music Editor |
| Cam McLauchlin | Music Editor |
| Cam McLauchlin | Title Designer |
| John Markle | Visual Effects Coordinator |
| Sylvain Morizet | Orchestrator |
| Patricia Keighran | Key Makeup Artist |
| Hayley Fromstein | Animation |
| Steve Switzer | Boom Operator |
| Anastasia Starova | Visual Effects Coordinator |
| Jill Purdy | Dialogue Editor |
| Warren Appleby | Special Effects Coordinator |
| Jean-Pascal Beintus | Orchestrator |
| Nigel Churcher | Art Direction |
| Brent Robinson | Underwater Camera |
| Ryan MacDuff | Visual Effects Coordinator |
| Alex Bullick | Sound Effects Editor |
| Rossana Vendramini | Key Hair Stylist |
| Peter Dydo | Animation |
| Carlos Arancibia | Animation |
| Kirsten Bligh | Visual Effects Coordinator |
| Paul Gosse | Sound Mixer |
| Jason Dodds | Rigging Gaffer |
| Ashley Gray | Casting Associate |
| Nate Thomas | Animation |
| Luke Groves | Visual Effects Producer |
| Steve Baine | Foley |
| Tyler Whitham | Sound Effects Editor |
| John Soukup | Sound Recordist |
| Lukas Press | Hairstylist |
| Gilles Corbeil | Camera Operator |
| Kevin Scott | Animation Director |
| Jae Won D. Lee | Visual Effects Coordinator |
| Dashen Naidoo | Sound Effects Editor |
| Nicolas Charron | Orchestrator |
| Dan Laustsen | Director of Photography |
| Dug Rotstein | Script Supervisor |
| Robin D. Cook | Casting |
| Jeff Poulis | Set Dresser |
| Brandon Schaafsma | Visual Effects Editor |
| Trey Harrell | Digital Effects Supervisor |
| Kevin Howard | Sound Effects Editor |
| Jeremy Johnson | Digital Compositor |
| Nelson Ferreira | Sound Editor |
| Edward Tracz | Stunt Double |
| Shaila D'Onofrio | Stunt Double |
| Christina Pitts Jazzar | Associate Choreographer |
| Alexandre Desplat | Original Music Composer |
