 | Ben Irish als Melvin / The Toxic Avenger |
 | Natalie Hope als The Mayor / Melvins mom / A nun |
 | Emma Salvo als Sarah |
 | Oscar Conlon-Morrey als Cop / Plant worker / female stylist / thug / doctor |
 | Che Francis als Cop / Plant worker / female stylist / thug / doctor |
| Benji Sperring | Director |
| Nick Morris | Director |
| Austin Shaw | Producer |
| Lloyd Kaufman | Executive Producer |
| Bonnie Comley | Executive Producer |
| Stewart F. Lane | Executive Producer |
| Joe DiPietro | Book |
| David Bryan | Musical |
| Lloyd Kaufman | Characters |
| David Bryan | Writer |
