 | Dwayne Johnson als Derek Thompson / Tooth Fairy |
 | Stephen Merchant als Tracy |
 | Ashley Judd als Carly |
 | Julie Andrews als Lily |
 | Ryan Sheckler als Mick Donnelly |
 | Seth MacFarlane als Ziggy |
 | Destiny Whitlock als Tess |
 | Chase Ellison als Randy |
 | Darien Provost als Gabe |
 | Alex Ferris als Shelter Cove Kid |
 | Nicole Muñoz als Kelly |
 | Brendan Meyer als Ben |
 | Josh Emerson als Kyle |
 | Brandon T. Jackson als Duke |
 | Dan Joffre als Tooth Fairy #1 |
 | Ellie Harvie als Permit Woman |
 | Barclay Hope als Coach |
 | Michael Daingerfield als Announcer |
 | Dale Wolfe als Color Commentator |
 | Anthony Bewlz als Brad |
 | Brendan Penny als Josh |
 | Lee Tichon als Andreas |
 | Jill Morrison als Shelter Cove Mom |
 | Rukiya Bernard als Amnesia Woman |
 | Maya Washington als Amnesia Daughter |
 | Daniel Bacon als Fan |
 | Christina Schild als Poltergeist Woman |
 | Nicholas Carella als Poltergeist Man |
 | Derek Gilroy als Crazed Fan |
 | Brendan Beiser als Teddy's Dad |
 | Fiona Hogan als Scared Woman |
 | Peter Kelamis als Talent Show Teacher |
| Steve Levy als Himself |
 | Candus Churchill als Amnesia Grandma |
 | David Quinlan als Gabe's Dad |
 | John Tench als Inmate |
| Ron Toffolo als Sports Reporter |
| Stephen Holmes als Shelter Cove Dad |
 | Billy Crystal als Jerry (uncredited) |
| Michael Lembeck | Director |
| Babaloo Mandel | Screenplay |
| Lowell Ganz | Screenplay |
| David Finfer | Editor |
| Joshua Sternin | Screenplay |
| Jennifer Ventimilia | Screenplay |
| Randi Mayem Singer | Screenplay |
| Jim Piddock | Story |
| George S. Clinton | Original Music Composer |
| David Tattersall | Director of Photography |
| Marcia Hinds | Production Design |
| Michael N. Wong | Art Direction |
| Mary-Lou Storey | Set Decoration |
| Angus Strathie | Costume Design |
| Heike Brandstatter | Casting |
| Mindy Marin | Casting |
| Coreen Mayrs | Casting |
| Gordon Gray | Producer |
| Jason Blum | Producer |
| Mark Ciardi | Producer |
| Jim Piddock | Executive Producer |
| Kevin Halloran | Co-Producer |
| Frankie Pine | Music Supervisor |
| Kevin Halloran | Unit Production Manager |
| Wendy Williams | Production Manager |
| Richard Cowan | First Assistant Director |
| David Klohn | Second Assistant Director |
| Guy Bews | Stunt Coordinator |
| Bo Johnson | Art Direction |
| Walter Ockley | Set Designer |
| Dean Sherriff | Production Illustrator |
| Diyah Pera | Still Photographer |
| David Husby | Sound Mixer |
| Don Brown | Boom Operator |
| Bryan Korenberg | Property Master |
| Susan Lambie | Script Supervisor |
| Haida Harper | Assistant Property Master |
| Steve Krasznai | Camera Loader |
| Stephen S. Campanelli | "A" Camera Operator |
| Stephen S. Campanelli | Steadicam Operator |
| Sean M. Harding | First Assistant "A" Camera |
| Tyler Woeste | Second Assistant "A" Camera |
| Terry McEwen | First Assistant "B" Camera |
| Jean-Marc Saldini | Second Assistant "B" Camera |
| Chuck Michael | Sound Designer |
| John Morris | Supervising Sound Editor |
| Paul Massey | Sound Re-Recording Mixer |
| David Giammarco | Sound Re-Recording Mixer |
| Linda Drake | Visual Effects Editor |
| Jake Morrison | Visual Effects Supervisor |
| Jamie Stevenson | Visual Effects Producer |
| Sarah Haddleton | Assistant Costume Designer |
| Andrew W. Davidson | Gaffer |
| Kim Olsen | Key Grip |
| Leon Serginson | Best Boy Grip |
| Keith Woods | Rigging Gaffer |
| Rosalina Da Silva | Makeup Department Head |
| Louis Lazzara | Makeup Artist |
| Rick Sharp | Makeup Artist |
| Anji Bemben | Hair Department Head |
| Terry Hanson | Hairstylist |
| Rachel Solow | Hairstylist |
| John Isaacs | Hairstylist |
| Catou Kearney | Location Manager |
| Terri Douglas | ADR Voice Casting |
| Gary Burritt | Negative Cutter |
| Chris Regan | Color Timer |
| Gary Archer | Prosthetics |
| Doug Chapman | Stunts |
| Krista Bell | Stunts |
