 | Denzel Washington als Frank Barnes |
 | Chris Pine als Will Colson |
 | Rosario Dawson als Connie Hooper |
 | Kevin Dunn als Galvin |
 | Lew Temple als Ned |
 | Kevin Corrigan als Inspector Werner |
 | Ethan Suplee als Dewey |
 | Kevin Chapman als Bunny |
 | Jessy Schram als Darcy Colson |
 | Elizabeth Mathis als Nicole Barnes |
 | Meagan Tandy als Maya Barnes |
 | David Warshofsky als Judd Stewart |
 | Andy Umberger als Janeway |
 | T.J. Miller als Gilleece |
 | Dylan Bruce als Michael Colson |
 | Jeff Hochendoner als Clark |
 | Ryan Ahern als Ryan Scott |
 | Christopher Lee Philips als Baker |
 | Kevin McClatchy als Hoffman |
| Toni Saladna als Galvin's Assistant |
 | Patrick McDade als Captain Allen |
 | Jeff Wincott als Jesse - Will's Brother |
 | Rick Chambers als News Reporter #1 |
| Bud Davis als Operator (uncredited) |
 | Bill Laing als Red Truck Driver |
 | Scott A. Martin als Brewster Dispatcher |
| Richard Pelzman als Devereaux |
| Lissa Brennan als Diner Waitress |
| Heather Morgan Leigh als Findlay Reporter |
| Barry Ben Sr. als Findlay Police Officer |
 | Carla Bianco als Horse Trailer Owner |
| Keith Michael Gregory als Hazma Worker |
 | L. Derek Leonidoff als FRA Official |
 | Aisha Hinds als Railway Safety Campaign Coordinator |
| David Flick als Train Engineer |
 | Rebecca Harris als Pauline |
 | Joshua Elijah Reese als Young Engineer |
 | Jason McCune als Radar Gun Cop |
 | Adrienne Wehr als News Reporter #8 |
 | Tom Stoviak als News Reporter #5 |
 | Joe Coyle als CEO Golfer #1 |
| Dihlon McManne als CEO Golfer #2 |
| Charles Van Eman als CEO Golfer #3 |
| Matthew J. Cates als State Trooper |
 | Warren Sweeney als Press Representative |
 | Chase Ellison als Teenage Witness |
 | Stephen Monroe Taylor als Truck Driver |
| Jarrod DiGiorgi als Control Room Staff #1 |
| Mike Clark als News Reporter #4 |
| Tony Scott | Producer |
| Alex Young | Producer |
| Eric McLeod | Producer |
| Rick Yorn | Executive Producer |
| Jeff Kwatinetz | Executive Producer |
| Ben Seresin | Director of Photography |
| Mark Bomback | Writer |
| Tony Scott | Director |
| Mimi Rogers | Producer |
| Julie Yorn | Producer |
| Chris Ciaffa | Executive Producer |
| Penny Rose | Costume Design |
| Chris Lebenzon | Editor |
| Chris Seagers | Production Design |
| Julian Ashby | Art Direction |
| Denise Hudson | Art Direction |
| Denise Chamian | Casting |
| Dawn Swiderski | Art Direction |
| Drew Boughton | Art Direction |
| Rosemary Brandenburg | Set Decoration |
| Robert Duffy | Editor |
| Stacy Horn | Costume Supervisor |
| Edouard F. Henriques | Makeup Department Head |
| Robert Zuckerman | Still Photographer |
| William B. Kaplan | Production Sound Mixer |
| Harry Gregson-Williams | Original Music Composer |
| Nerses Gezalyan | Sound Mixer |
| Joshua Stern | Rigging Gaffer |
| Elayaraja | Visual Effects Coordinator |
| John T. Connor | Camera Operator |
| Michael Shelton | Lead Animator |
| Diane Dixon | Hairstylist |
| Carl Fullerton | Makeup Artist |
| Simone Perusse | Lighting Technician |
| John Frazier | Special Effects Supervisor |
| Yolanda Toussieng | Hair Department Head |
| Larry M. Cherry | Hairstylist |
| Michael Wahl | Dolly Grip |
| Ralph Del Castillo | Dolly Grip |
| Christina Romney-Glotzer | Art Department Coordinator |
| Skip Haswell | Rigging Grip |
| Paul O'Shea | Visual Effects Supervisor |
| Bruno Van Zeebroeck | Special Effects Coordinator |
| Wyatt Belton | Key Hair Stylist |
| Carla S. Nemec | Art Department Coordinator |
| Dan Jarrell | Rigging Grip |
| John Skotchdopole | Camera Operator |
| Scott Sprague | Lighting Technician |
| Bret St. Clair | CG Supervisor |
| Sandra Linn Koepper | Makeup Artist |
| Debi Young | Makeup Artist |
| Jose Marra | Visual Effects Editor |
| Danny Moumdjian | Hair Designer |
| Jason Schugardt | CG Supervisor |
| Duane Floch | Pre-Visualization Supervisor |
| Kosta Saric | Visual Effects Editor |
| Mike Villarino | Construction Coordinator |
| Eugene McCarthy | Property Master |
| Joe Pancake | Special Effects Coordinator |
| Diane Heller | Key Makeup Artist |
| Natasha Ladek | Wigmaker |
| Mark Meyers | Steadicam Operator |
| Kimberly Covate | Visual Effects Producer |
| Rachel Kick | Makeup Artist |
| Mark Mahoney | Tattooist |
| Dale DeStefani | Construction Coordinator |
| Darin Moran | Camera Operator |
| Martin Schaer | Camera Operator |
| Pat Dames | Rigging Grip |
| Diana Cheng | Visual Effects Coordinator |
| Mark P. Stoeckinger | Supervising Sound Editor |
| Jack English | Gaffer |
| Chuck Picerni Jr. | Stunt Coordinator |
| Gary Powell | Stunt Coordinator |
| Clay Cullen | Stunts |
| Michael Runyard | Stunt Driver |
| Keith Campbell | Stunt Driver |
| Jeremy Fry | Stunt Double |
