 | Kristen Wiig als Erin Gilbert |
 | Melissa McCarthy als Abby Yates |
 | Kate McKinnon als Jillian Holtzmann |
 | Leslie Jones als Patty Tolan |
 | Chris Hemsworth als Kevin |
 | Neil Casey als Rowan North |
 | Charles Dance als Harold Fillmore |
 | Michael Kenneth Williams als Agent Hawkins |
 | Cecily Strong als Jennifer Lynch |
 | Andy García als Mayor Bradley |
 | Matt Walsh als Agent Rorke |
 | Ed Begley Jr. als Ed Mulgrave |
 | Steve Higgins als Dean Jones |
 | Michael McDonald als Jonathan |
 | Karan Soni als Benny |
 | Zach Woods als Tour Guide |
 | Nate Corddry als Graffiti Artist |
 | Toby Huss als Officer Stevenson |
 | Katie Dippold als Rental Agent |
 | Jessica Chaffin als Waitress |
 | Jamie Denbo als Waitress |
 | Steve Bannos als Flasher Ghost |
 | Adam Ray als Lead Singer / Slimer (voice) |
 | Bill Murray als Martin Heiss |
 | Dan Aykroyd als Cabbie |
 | Ernie Hudson als Uncle Bill |
 | Sigourney Weaver als Rebecca Gorin |
 | Annie Potts als Desk Clerk |
 | Ozzy Osbourne als Famous Rock Star |
 | Al Roker als Al Roker |
 | Rosanna Scotto als Fox 5 News Anchor |
 | Greg Kelly als Fox 5 News Anchor |
| Daniel Ramis als Metal Head |
 | Sam Richardson als Basement Cop |
 | Milana Vayntrub als Subway Rat Woman |
 | Bess Rous als Gertrude Aldridge Ghost |
 | Pat Kiernan als NY1 News Anchor #1 |
 | Eugene Cordero als Bass Guitarist |
 | Jeanine Ramirez als Reporter Outside Theater |
 | Tom Yi als Flashed Man |
 | Susan Park als Flashed Woman |
 | Stephen 'tWitch' Boss als Police Officer |
 | Robin Shelby als Lady Slimer (voice) |
 | John Milhiser als Higgins Student |
 | Ben Harris als Higgins Student |
| Jaime Pacheco als Fernando |
| Davey Jones als Ely the Drummer |
| Ryan Levine als Rock Guitarist |
| Dan Teicher als Rock Guitarist |
 | Theodore Shapiro als Keyboardist |
| Matteo Borghese als Lightboard Operator |
| Cheryl Wills als NY1 News Anchor #2 |
 | Tony Viveiros als Police Officer |
| Johnny Higgins als Baba Booey Shouter |
 | Elizabeth Perkins als Phyllis Adler (uncredited) |
 | Stephanie Atkinson als Restaurant Patron (uncredited) |
 | Brian Baumgartner als Frank (uncredited) |
 | Paige MacLean als Concert Goer (uncredited) |
 | Lesley Nicol als Mrs. Potter (uncredited) |
| Lexie Roth als Guitar Technician (uncredited) |
| Kallie Tabor als Community College Student (uncredited) |
| Jordan Tofalo als 1950s Ghost (uncredited) |
 | John Franchi als NYC Pedestrian (uncredited) |
 | Dave Allen als Electrocuted Ghost |
 | Jason Tisi als Precision Driver (uncredited) |
 | Arthur Hiou als John Gotti Ghost (uncredited) |
 | Chris Gethard als Blogger (uncredited) |
| Dan Aykroyd | Executive Producer |
| Dan Aykroyd | Characters |
| Harold Ramis | Characters |
| Beat Frutiger | Supervising Art Director |
| Theodore Shapiro | Original Music Composer |
| Robert D. Yeoman | Director of Photography |
| Jeffrey Kurland | Costume Design |
| Leslie A. Pope | Set Decoration |
| Ivan Reitman | Producer |
| Tony Lamberti | Sound Designer |
| Brenda McNally | Hair Department Head |
| Alan D'Angerio | Hairstylist |
| Trish Seeney | Makeup Department Head |
| Brent White | Editor |
| Allison Jones | Casting |
| Jefferson Sage | Production Design |
| Michele Imperato | Executive Producer |
| Tom Pollock | Executive Producer |
| Joe Medjuck | Executive Producer |
| Andrew Doucette | Animation Supervisor |
| Jennifer Pearson | Visual Effects Editor |
| Paul Feig | Screenplay |
| Paul Feig | Director |
| Paul Feig | Executive Producer |
| Beau Borders | Sound Re-Recording Mixer |
| Lorin Flemming | Art Direction |
| Cindy M. Ichikawa | Art Department Coordinator |
| Darren Sunny Warkentin | Dialogue Editor |
| Andrew DeCristofaro | Supervising Sound Editor |
| Matt Mullins | Stunt Double |
| G. A. Aguilar | Stunt Coordinator |
| G. A. Aguilar | Second Unit Director |
| Katie Dippold | Screenplay |
| Ali Bell | Executive Producer |
| Bradley Rubin | Art Direction |
| John Casey | Costume Supervisor |
| Joseph Kearney | Construction Coordinator |
| Dan O'Connell | Foley Artist |
| Pinto Sasikumar | Visual Effects Producer |
| Rick Owens | Foley Artist |
| John T. Cucci | Foley |
| Audra Avery | Art Direction |
| Tricia Yoo | Set Costumer |
| Peter John Kousakis | Casting Associate |
| Michael J. Broomberg | Foley Artist |
| Peter G. Travers | Visual Effects Supervisor |
| Heba Thorisdottir | Makeup Artist |
| James Paul | Associate Producer |
| Ineke Majoor | Visual Effects Producer |
| Mark Paterson | Sound Re-Recording Mixer |
| Zack Mazerolle | Visual Effects Editor |
| Casey Hotchkiss | Camera Operator |
| Sheila Waldron | Script Supervisor |
| Phil Pastuhov | Helicopter Camera |
| Becky Sullivan | Supervising Sound Editor |
| Laura Harris Atkinson | Dialogue Editor |
| Phil Barrie | Sound Effects Editor |
| Linda D. Flowers | Hairstylist |
| Hopper Stone | Still Photographer |
| David Esparza | Sound Effects Editor |
| Jarred Waldron | Gaffer |
| Janine Rath | Makeup Artist |
| Steve Miller | Visual Effects Editor |
| David Stanke | First Assistant Sound Editor |
| Brian Drewes | Visual Effects Producer |
| Don Libby | CG Supervisor |
| Dave Cambria | Rigging Gaffer |
| Amy Pascal | Producer |
| Nancy St. John | Visual Effects Producer |
| Nichole Pleau | Makeup Artist |
| Jill Brown | Stunts |
| Terence Bannon | Animation Supervisor |
| Pamela S. Westmore | Makeup Artist |
| Tim Johnson | Visual Effects Producer |
| Iain McFadyen | Art Direction |
| Graham Martin | VFX Production Coordinator |
| Rebecca Breckel | Script Supervisor |
| Richard Roles | Helicopter Camera |
| Jessie Henderson | Executive Producer |
| Melissa Bretherton | Editor |
| Mark Hawker | Special Effects Supervisor |
| Dennis Bailey | Key Hair Stylist |
| Jennifer Starzyk | Assistant Costume Designer |
| Erica Weis | Music Editor |
| John Vecchio | Gaffer |
| Ken O'Keefe | First Assistant Editor |
| Caroline Vexler | Stunt Double |
| Eric Laudadio | Additional Photography |
| David Quinn | Visual Effects Editor |
| Jill Bogdanowicz | Digital Intermediate |
| Cesha Ventre | Set Costumer |
| Annis Naeem | Conceptual Design |
| Ben Harris | Casting Associate |
| Aaron Kahl | Casting Associate |
| Amanda Hannan | Set Costumer |
| Erica Suzanne Scott | Set Costumer |
| Avi Goodman | CG Supervisor |
| Michael Muir | CG Supervisor |
| Michael Gilbert | Visual Effects Editor |
| Ryan Brassington | Visual Effects Editor |
| William Maurer | Visual Effects Producer |
| Natalie Young | Makeup Department Head |
| Raquel Vivve | Makeup Artist |
| Alex Plapinger | Associate Producer |
| Eric Reich | Associate Producer |
| Dennis Colvin | Set Decoration |
| Tina Mckissick | Stunt Double |
| Luci Romberg | Stunt Double |
