 | Steve Carell als Gru (voice) |
 | Miranda Cosgrove als Margo (voice) |
 | Dana Gaier als Edith (voice) |
 | Elsie Fisher als Agnes (voice) |
 | Jason Segel als Vector (voice) |
 | Russell Brand als Dr. Nefario (voice) |
 | Julie Andrews als Gru's Mother (voice) |
 | Will Arnett als Mr. Perkins (voice) |
 | Kristen Wiig als Miss Hattie (voice) |
 | Pierre Coffin als Tim / Bob / Mark / Phil / Stuart (voice) |
 | Chris Renaud als Dave (voice) |
 | Jemaine Clement als Jerry (voice) |
 | Jack McBrayer als Carnival Barker / Tourist Dad (voice) |
 | Danny McBride als Fred McDade (voice) |
 | Mindy Kaling als Tourist mom (voice) |
 | Rob Huebel als Anchorman (voice) |
 | Ken Daurio als Egyptian Guard (voice) |
 | Ken Jeong als Talk Show Host (voice) |
 | Charles Bright als Additional Voices (voice) |
 | Katie Leigh als Additional Voices (voice) |
 | Ranjani Brow als Additional Voices (voice) |
 | Scott Menville als Additional Voices (voice) |
 | Holly Dorff als Additional Voices (voice) |
 | Edie Mirman als Additional Voices (voice) |
| Jackie Gonneau als Additional Voices (voice) |
 | Al Rodrigo als Additional Voices (voice) |
 | Wendy Hoffmann als Additional Voices (voice) |
| Jakob Roston als Additional Voices (voice) |
 | James Kyson als Additional Voices (voice) |
 | John Hans Tester als Additional Voices (voice) |
| Tony Lee als Additional Voices (voice) |
 | Debi Mae West als Additional Voices (voice) |
| Hans Zimmer | Music Score Producer |
| Tom Johnson | Sound Re-Recording Mixer |
| Christopher Meledandri | Producer |
| Mary Hidalgo | Casting |
| Mary Hidalgo | Casting Consultant |
| Carter Goodrich | Character Designer |
| Robert Taylor | Associate Producer |
| Dennis Leonard | Supervising Sound Editor |
| Daniel Laurie | ADR Supervisor |
| Gregory Perler | Editor |
| Ken Daurio | Screenplay |
| Cinco Paul | Screenplay |
| Heitor Pereira | Original Music Composer |
| Yarrow Cheney | Production Design |
| Holly Dorff | ADR Voice Casting |
| Janet Healy | Producer |
| Kevin Kaska | Orchestrator |
| Pam Ziegenhagen | Editor |
| Rick Giovinazzo | Orchestrator |
| Steve Bissinger | Sound Effects Editor |
| Nina Rappaport | Executive Producer |
| Fabrice Joubert | Animation |
| Pierre Coffin | Director |
| Chris Renaud | Director |
| Sergio Pablos | Executive Producer |
| Sergio Pablos | Story |
| Pharrell Williams | Original Music Composer |
| Bruce Fowler | Orchestrator |
| Joey Newman | Conductor |
| Eric Guillon | Art Direction |
| Eric Guillon | Character Designer |
| Sergio Casas | Color Designer |
| Clément Griselain | Color Designer |
| Paul Mager | Set Designer |
| Loïc Rastout | Set Designer |
| Jean Hemez | Lead Animator |
| Patrick Voetberg | Associate Editor |
| John Cohen | Producer |
| Carlos Felipe León Ortiz | Color Designer |
| Cal Brunker | Storyboard |
| Chris Westlake | Original Music Composer |
| Armen Ksajikian | Musician |
| Nicole Rivelli | Still Photographer |
| Stephan Franck | Storyboard |
| Christine Lagarde | Thanks |
| Dave Rosenbaum | Script Supervisor |
| Dave Rosenbaum | Executive In Charge Of Production |
| Olivier Delabarre | Color Designer |
| Rodolphe Chabrier | Thanks |
| Sean England | Foley |
| Sandy Buchanan | Sound Recordist |
| Slamm Andrews | Music Editor |
| Jeremy Bowker | Sound Effects Editor |
| David C. Hughes | Sound Effects Editor |
| Christopher Scarabosio | Sound Designer |
| Christopher Scarabosio | Supervising Sound Editor |
| Christopher Scarabosio | Sound Re-Recording Mixer |
| E. Larry Oatfield | Foley Editor |
| Vicki Hiatt | Supervising Music Editor |
| Mary Bills | Script Supervisor |
| Leff Lefferts | Sound Design Assistant |
| Jeannine Berger | Post Production Supervisor |
| Yannick Honore | Animation |
| Vivian David | Lighting Artist |
| Loïc Miermont | Animation |
| Walt Fowler | Orchestrator |
| Mitja Rabar | Animation |
| Lucien Fostier | Digital Compositors |
| Satnam Ramgotra | Musician |
| Moïse Essame | Animation |
| Pierre Leduc | Supervising Animator |
| Patrick Delage | Lead Animator |
| Alex Dowding | Editorial Manager |
| Julien Soret | Supervising Animator |
| Kathy Nelson | Music Supervisor |
| Claire Dodgson | Additional Editing |
| Steven Liu | Additional Editing |
| Tony Gonzalez | Choreographer |
| Gourdal Sebastien | Lighting Artist |
| Terry Claborn | Color Timer |
| Emmanuelle Carlier | Visual Effects Producer |
| Gavin Greenaway | Music Director |
| Tim Davies | Conductor |
| Matthieu Chatelier | Digital Compositors |
| Bruno Chauffard | CG Supervisor |
| Tyler Werrin | Editorial Production Assistant |
| Carl Rydlund | Orchestrator |
| Karen Hathaway | Assistant Editor |
| Bart Boirot | Supervising Animator |
| Bart Boirot | Lead Animator |
| Jean-Luc Florinda | Production Manager |
| Rudyard Cretenet | Digital Compositors |
| Carlos Sotolongo | ADR & Dubbing |
| Miguel Ángel Poveda | Post Production Supervisor |
| Olivier Lukaszczyk | Digital Compositors |
| Michael Jesmer | Sound Recordist |
| Ségolène Amice Lagny | Production Coordinator |
| Robin Joseph | Visual Development |
| Justine Codron | Lighting Artist |
| Michael Crouzat | Key Animation |
| Roy Latham | ADR & Dubbing |
| Franklin Jones III | ADR Editor |
| Lionel Gallat | Animation Director |
| Anais Perlot | Animation Manager |
| Laurent de la Chapelle | Animation Supervisor |
| Jean-François Macé | Visual Effects Technical Director |
| Daniel Callaby | Animation |
| Lang-Willar Chloe | Animation |
| Céline Chotard | Animation |
| Mathilde Fabry | Animation |
| Audrey Fobis | Animation |
| Vincent Garcia | Animation |
| Guillaume Herent | Animation |
| Silke Jager | Animation |
| Francois Laurent | Animation |
| Mathieu Gérard | Animation |
| Renaud Mégange | Animation |
| Elena Ortego | Animation |
| Julen Santiago | Animation |
| Jean-François Barthélémy | Animation |
| Clementine Tronel | Animation |
| Karin Kempf | Animation |
| Katie Ballentine | Art Department Coordinator |
| Gilad Carmel | Assistant Editor |
| Michael Rostker | Assistant Editor |
| Solenn Colas | Assistant Production Manager |
| Karine Friang | Assistant Production Manager |
| Joy Poirel | Assistant Production Manager |
| Jerome Auliac | Digital Compositors |
| Florian Bestel | Digital Compositors |
| Jean-Nicolas Costa | Digital Compositors |
| Clement Darbois | Digital Compositors |
| Antoine Douadi | Digital Compositors |
| Christophe Duflaut | Digital Compositors |
| Delphine Garrelis | Digital Compositors |
| Philippe Huberdeau | Digital Compositors |
| Jola Kudela | Digital Compositors |
| Khaled Labidi | Digital Compositors |
| François Le Bastard | Digital Compositors |
| Thomas Lefebvre | Digital Compositors |
| Jeanne Loyer | Digital Compositors |
| Gaston Marcotti | Digital Compositors |
| Maya Pelle | Digital Compositors |
| Alexis Peraste | Digital Compositors |
| Simon Rafin | Digital Compositors |
| Dane Rapaport | Digital Compositors |
| Marine Samyn | Digital Compositors |
| Niranjan Siva | Digital Compositors |
| Jeremy Séguin | Digital Compositors |
| Gerome Viavant | Digital Compositors |
| Anthony Voisin | Digital Compositors |
| Stephan Guerin | Digital Compositors |
| Stephanie Saillard | Digital Compositors |
| Jason Hanel | Digital Intermediate |
| Josh Morgan | Editorial Coordinator |
| Ed Fuller | First Assistant Editor |
| Stephane Mangin | Lead Animator |
| Alexandre Bermond | Lighting Artist |
| Saïdou Bernabé | Lighting Artist |
| Vincent Blanqué | Lighting Artist |
| Cédric Burkarth | Lighting Artist |
| Blandine Chanteur | Lighting Artist |
| Pierre Gobilliard | Lighting Artist |
| Pierre Lopes | Lighting Artist |
| Olivier Martiny | Lighting Artist |
| Le Meur Mathieu | Lighting Artist |
| Matthieu Molina | Lighting Artist |
| Hugues Ssosse | Lighting Artist |
| Ephraïm Drouet | Lighting Artist |
| Benoit Fournol | Lighting Artist |
| Scott Hosfeld | Musician |
| Peter Buccellato | ADR & Dubbing |
| Julien Sabourdin | Production Accountant |
| Frédéric Greene | Production Accountant |
| Christelle Balcon | Production Manager |
| Christina DeSilva | Production Manager |
| Wassila Lmouaci | Production Manager |
| Jill Ragaway | Production Manager |
| Guillaume Boudeville | Rigging Supervisor |
| Fabian Marascuillo | Score Engineer |
| Oren Hadar | Scoring Mixer |
| Vincent Massy | Set Designer |
| Eric Placoly | Software Engineer |
| Christophe Asselin | Thanks |
| Pierre Avon | Supervising Animator |
| Nicolas Bauduin | Supervising Animator |
| Elisabeth Patte | Supervising Animator |
| Charles Chorein | Visual Effects |
| Vincent Houze | Visual Effects |
| Elodie Labbe | VFX Artist |
| Mathieu Malard | VFX Artist |
| Marie-Claire Bazart | VFX Supervisor |
