 | Steve Carell als Gru / Dru (voice) |
 | Kristen Wiig als Lucy Wilde (voice) |
 | Trey Parker als Balthazar Bratt (voice) |
 | Miranda Cosgrove als Margo (voice) |
 | Dana Gaier als Edith (voice) |
 | Nev Scharrel als Agnes (voice) |
 | Steve Coogan als Fritz / Silas Ramsbottom (voice) |
 | Julie Andrews als Gru’s Mom (voice) |
 | Jenny Slate als Valerie Da Vinci (voice) |
 | Pierre Coffin als Mel / Minions / Museum Director / Additional Voices (voice) |
 | Chris Renaud als Additional Minions (voice) |
 | Andy Nyman als Clive the Robot (voice) |
 | Michael Beattie als The Scar Faced Man / TMZ Announcer (voice) |
 | Adrian Ciscato als Niko (voice) |
 | Brian T. Delaney als Commercial Announcer / Military Officer / Additional Voice (voice) |
 | Ken Daurio als Celebrity (voice) |
 | Lori Alan als Additional Voices (voice) |
 | Carlos Alazraqui als Additional Voices (voice) |
 | Kyle Balda als Additional Voices (voice) |
 | Teresa Ganzel als Additional Voices (voice) |
 | Bob Bergen als Additional Voices (voice) |
 | Jess Harnell als Additional Voices (voice) |
 | Gregg Berger als Additional Voice (voice) |
 | John Kassir als Additional Voice (voice) |
 | Mona Marshall als Additional Voice (voice) |
 | John Cygan als Additional Voice (voice) |
 | Laraine Newman als Additional Voice (voice) |
 | Jan Rabson als Additional Voices (voice) |
 | Bill Farmer als Additional Voices (voice) |
 | Mindy Sterling als Additional Voice (voice) |
 | Danny Mann als Additional Voices (voice) |
 | Jim Ward als Additional Voice (voice) |
 | Matthew Wood als Additional Voice (voice) (uncredited) |
 | Katia Saponenko als Niko’s Mother (voice) |
| Jude Alpers als Commercial Kid (voice) |
 | Cory Walls als Vincenzo (voice) |
| Sophie M. Siadatpour als Little Girl (voice) |
| Stephanie De Meautis als Additional Voice (voice) |
| Bruno Dequier als Additional Voice (voice) |
| Gregg Berger als Additional Voices (voice) |
 | Tara Strong als Additional Voices (voice) |
| Kyle Balda | Director |
| Pierre Coffin | Director |
| Ken Daurio | Writer |
| Jill Ambrosino | Visual Effects |
| John R.A. Benson | Stereoscopic Coordinator |
| Jonathan Beard | Orchestrator |
| Eric Guillon | Co-Director |
| Chris Meledandri | Producer |
| Janet Healy | Producer |
| Brett Hoffman | Associate Producer |
| Cinco Paul | Writer |
| Robert Taylor | Associate Producer |
| Richard Gould | Foley Editor |
| Chris Renaud | Executive Producer |
| Claire Dodgson | Editor |
| Olivier Adam | Art Direction |
| Heitor Pereira | Original Music Composer |
| Pharrell Williams | Songs |
| Nicolas Brack | Lighting Supervisor |
| Diane Howard | Publicist |
| Patrick Bloche | Thanks |
| Frédérique Bredin | Thanks |
| Constance Buccafurri | Thanks |
| Thierry de Segonzac | Thanks |
| Chihiro Kameyama | Thanks |
| Françoise Pams | Thanks |
| Stéphane Lebars | Thanks |
| Tim Nielsen | Additional Sound Re-Recording Mixer |
| Tim Nielsen | Supervising Sound Editor |
| Tim Nielsen | Sound Designer |
| Ludovic Savonnière | Lead Animator |
| Ludovic Savonnière | Supervising Animator |
| Michael Miller | ADR & Dubbing |
| Wouter van Herwerden | ADR & Dubbing |
| Mickie McGowan | ADR Voice Casting |
| Adeline Grange | Animation |
| Adrian Villarino | Animation |
| Albert Barba Cunill | Animation |
| Alexandre Melquiond | Animation |
| Andrea Giro | Animation |
| Barbara Dossi | Animation |
| Craig Peck | Animation |
| Damien Duprat | Animation |
| David Carrière | Animation |
| Diego S. Mezquiriz | Animation |
| Eddy Okba | Animation |
| Eike Hoppmann | Animation |
| Fabrice Senia | Animation |
| Jean Duval | Animation |
| Lucas Veber | Animation |
| Luke Burnet | Animation |
| Martin Campos Amoros | Animation |
| Mourad Simoussa | Animation |
| Nicolas Ménard | Animation |
| Olivier Montero | Animation |
| Pierre-Baptiste Marty | Animation |
| Sophie Zourane | Animation |
| Vincent Lemaire | Animation |
| Bruno Dequier | Animation Director |
| Julien Soret | Animation Director |
| Gaëlle Santamarta | Assistant Production Manager |
| Zach Martin | Assistant Sound Editor |
| Gilad Carmel | Associate Editor |
| Zurine Ainz | Associate Editor |
| Bruno Chauffard | CG Supervisor |
| Frank Baradat | CG Supervisor |
| Carter Goodrich | Character Designer |
| Nicolas Bauduin | Character Designer |
| Gregory Georges | Color Designer |
| Patrick Muylkens | Color Designer |
| Alexandre Marlier | Compositors |
| Nick Glennie-Smith | Conductor |
| Baptiste Chauveau | Digital Compositors |
| Brian Padilla | Digital Compositors |
| Guillem Ramisa de Soto | Digital Compositors |
| Maxime Poron | Digital Compositors |
| Pablo Gotor | Digital Compositors |
| Rudyard Cretenet | Digital Compositors |
| Amy Pawlowski | Digital Intermediate |
| Lisa Shaw Phillips | First Assistant Editor |
| Romana Reeve | First Assistant Editor |
| Scott A. Jacobs | First Assistant Editor |
| Geoff Vaughan | Foley |
| John Roesch | Foley |
| Shelley Roden | Foley |
| Florent de La Taille | Lead Animator |
| Jack Vandenbroele | Lead Animator |
| Catherine Catie Lee | Lighting Artist |
| Cedric Launay | Lighting Artist |
| Mathieu Krysztoforski | Lighting Artist |
| Sylvain Potel | Master Lighting Artist |
| Slamm Andrews | Music Editor |
| Bart Samolis | Musician |
| Bruce White | Musician |
| David Arch | Musician |
| Eric Bradley | Musician |
| Heitor Pereira | Musician |
| Helen Z. Altenbach | Musician |
| Jonathan Williams | Musician |
| Mark Berrow | Musician |
| Nicholas Bucknall | Musician |
| Rachel Bolt | Musician |
| Edward Trybek | Orchestrator |
| Henri Wilkinson | Orchestrator |
| Jeannine Berger | Post Production Supervisor |
| Demetrios Tzamaras | Production Coordinator |
| François de Chateleux | Production Coordinator |
| Loni J. Albertson | Production Supervisor |
| Guillaume Boudeville | Rigging Supervisor |
| Greg Loskorn | Score Engineer |
| Greg Hayes | Scoring Mixer |
| Noah Scot Snyder | Scoring Mixer |
| Kelly Lake | Script Supervisor |
| Edwin Rhemrev | Set Designer |
| Thomas Reteuna | Set Designer |
| Florence Putzola | Set Dressing Supervisor |
| Mélissa Faucher | Software Engineer |
| Andre Zweers | Sound Effects Editor |
| Mac Smith | Sound Effects Editor |
| Danny Ferraro | Sound Recordist |
| Brandon Proctor | Sound Re-Recording Mixer |
| Randy Thom | Sound Re-Recording Mixer |
| Simon Popot | Special Effects |
| Cécile Brossette | Supervising Animator |
| Hichem Arfaoui | Supervising Animator |
| Pierre Avon | Supervising Animator |
| Dennis Leonard | Supervising Sound Editor |
| Eric Carme | VFX Artist |
| Marc Lamorille | VFX Artist |
| Mika Margolles | VFX Artist |
| Pablo Penchansky | VFX Artist |
| Rodrigue El Hajj | VFX Artist |
| Sergio Juan Gomez | VFX Artist |
| Tom O'Bready | VFX Artist |
| Brett Nystul | Visual Development |
| Guillaume Fesquet | Visual Development |
| Axelle De Cooman | Visual Effects |
| Ben Fournet | Visual Effects |
| Francois Boussard | Visual Effects |
| François-Xavier Lepeintre | Visual Effects |
| Pierre Lopes | Visual Effects |
| Timo Berg | Animation |
| Greg Crawford | ADR & Dubbing |
| Benjamin Faure | Animation |
| Cinzia Angelini | Storyboard Artist |
| Basile Heiderscheid | Lead Animator |
