 | Jeff Goldblum als Nick Deezy |
 | Cyndi Lauper als Sylvia Pickel |
 | Peter Falk als Harry Buscafusco |
 | Googy Gress als Ingo Swedlin |
 | Julian Sands als Dr. Harrison Steele |
 | Darryl Henriques als Ricardo |
 | Ramon Bieri als Eli Diamond |
 | Michael Lerner als Burt Wilder |
 | Leo V. Finnie III als Monty Man |
 | Rodney Kageyama als Dr. Harmon |
 | Van Dyke Parks als Dr. Weiner |
 | Hercules Vilchez als Juan |
| Jerry Vichi als Baseball Man |
| Ray Stoddard als Dr. Scott |
| Harvey J. Goldenberg als Lyle |
 | Tom Henschel als Dr. Drake |
| Susan Bugg als Dr. Silver |
 | Steve Buscemi als Fred |
 | Joseph V. Perry als Dave |
 | Park Overall als Jane |
 | Max Perlich als Busboy |
 | John Kapelos als Eugene |
 | Bruce MacVittie als Tony |
| Don Bexley als Lou |
 | Bill McCutcheon als Mr. Van Der Meer |
 | Jennifer Balgobin als Gloria |
 | Karen Akers als Hillary |
| Fernando Verdugo als Bellhop |
 | Ronald G. Joseph als Carl |
| Aharon Ipalé als Alejandro De La Vivar |
 | Elizabeth Peña als Consuelo |
 | Robert Covarrubias als Waiter |
| Elvira De Val als Nurse |
| Ronald Paul Ramirez als Hotel Clerk |
| Ken Kwapis | Director |
| Deborah Blum | Story |
| Lowell Ganz | Story |
| Babaloo Mandel | Story |
| Lowell Ganz | Screenplay |
| Babaloo Mandel | Screenplay |
| Deborah Blum | Producer |
| Tony Ganz | Producer |
| Raymond Hartwick | Co-Producer |
| Ron Howard | Executive Producer |
| Kate Long | Associate Producer |
| David Wolff | Associate Producer |
| James Horner | Original Music Composer |
| Carol Littleton | Editor |
| Regina Gruss | Publicist |
| Dan Perri | Title Designer |
| John Bailey | Director of Photography |
| Tom Seidman | Second Assistant Director |
| Carrie Frazier | Casting |
| Shani Ginsberg | Casting |
| Richard Edlund | Visual Effects Producer |
| Ruth Myers | Costume Design |
| Richard Sawyer | Production Design |
| Anne Rapp | Script Supervisor |
| Raymond Hartwick | Unit Production Manager |
| Alan B. Curtiss | First Assistant Director |
| Lou Barlia | Camera Operator |
| Donald E. Thorin Jr. | First Assistant Camera |
| Michael Raspa | Second Assistant Camera |
| Bruce McBroom | Still Photographer |
| Raúl Dávalos | Assistant Editor |
| Lisa Zeno Churgin | First Assistant Editor |
| Richard Bryce Goodman | Production Sound Mixer |
| Carl Fischer | Boom Operator |
| Dennis Drummond | Supervising Sound Editor |
| George H. Anderson | Sound Editor |
| Cindy Marty | Sound Editor |
| Roxanne Jones McCarthy | Sound Editor |
| Jeff Rosen | Sound Editor |
| Bobbe Kurtz | Supervising ADR Editor |
| Beth Bergeron | ADR Editor |
| Jim Henrikson | Music Editor |
| Paul A. Sharpe | Sound Re-Recording Mixer |
| Doug Hemphill | Sound Re-Recording Mixer |
| Edward F. Suski | Sound Re-Recording Mixer |
| Gregory Pickrell | Art Direction |
| George R. Nelson | Set Decoration |
| David F. Klassen | Set Designer |
| Tom Cranham | Production Illustrator |
| Dennis DeWaay | Construction Coordinator |
| Steve Fegley | Construction Foreman |
| Donald Krafft | Leadman |
| John A. Mileski | Standby Painter |
| Allen Hall | Special Effects Coordinator |
| John Branagan | Stunt Coordinator |
| Louis S. Fleming | Property Master |
| Mike Carrillo | Assistant Property Master |
| Alan Friedman | Makeup Artist |
| Marlene D. Williams | Hairstylist |
| Norma Lee | Hairstylist |
| Ronald W. McLeish | Gaffer |
| Michael M. Krevitt | Key Grip |
| George R. Schrader | Dolly Grip |
| Shari Leibowitz | Production Coordinator |
| Murray Miller | Location Manager |
| John M. Woodward | Transportation Coordinator |
| Frank DeMichelis | Craft Service |
| Donah Bassett | Negative Cutter |
| Phil Downey | Color Timer |
| Patrick J. Statham | Stunt Coordinator |
| Joni Avery | Stunts |
| Charles Croughwell | Stunts |
| Jorge Gundín | Production Manager |
| Miranda Garrison | Choreographer |
