 | Ice Cube als Darius Stone / xXx |
 | Samuel L. Jackson als Agent Augustus Gibbons |
 | Willem Dafoe als Gen. George Octavius Deckert |
 | Scott Speedman als Agent Kyle Steele |
 | Peter Strauss als President James Sandford |
 | Xzibit als Zeke |
 | Michael Roof als Toby Lee Shavers |
 | Sunny Mabrey als Charlie Mayweather |
 | Nona Gaye als Lola Jackson |
 | John G. Connolly als Lt. Alabama "Bama" Cobb |
 | Ramon De Ocampo als Agent Meadows |
 | Barry Sigismondi als Bull |
 | J. Anthony Brown als Webster |
 | Bruce Bruce als Maurice |
 | David Rountree als Agent |
 | Ned Schmidtke als Col. Jack Pettibone |
 | Lisa Joyner als Field Reporter at Fire |
 | Gina St. John als Field Reporter |
 | Michael Don Evans als Conductor |
| Brian Larsen als Bridge Actor (uncredited) |
 | Jeanne Sakata als Field Reporter |
 | Jeffrey Moon als Soldier |
 | Todd Louiso als Dickie Ambrose (uncredited) |
 | Matt Gerald als Liebo |
 | Eddy Shalita als SWAT (uncredited) |
 | J. J. Perry als Military Police (uncredited) |
| Mark Goldblatt | Editor |
| Christopher Boyes | Sound Designer |
| Bill Abbott | Music Editor |
| Steven Rosenblum | Editor |
| Sanja Milković Hays | Costume Design |
| Marco Beltrami | Original Music Composer |
| John Frazier | Special Effects Supervisor |
| Margery Simkin | Casting |
| David Tattersall | Director of Photography |
| Lee Tamahori | Director |
| Hilton Rosemarin | Set Decoration |
| Stella Vaccaro | Art Direction |
| Arne Schmidt | Producer |
| Debra James | Unit Production Manager |
| Simon Kinberg | Screenplay |
| Derek Dauchy | Executive Producer |
| Todd Garner | Executive Producer |
| Neal H. Moritz | Producer |
| Robert Deschaine | ADR Recordist |
| Jim Passon | Color Timer |
| R. A. Rondell | Stunt Coordinator |
| Rob Cohen | Executive Producer |
| Gavin Bocquet | Production Design |
| Geoff Murphy | Second Unit Director |
| Rich Wilkes | Characters |
| Todd E. Miller | Editor |
| Luke Freeborn | Assistant Art Director |
| Darren Higman | Music Supervisor |
| Laura Ziffren | Music Supervisor |
| Allan A. Apone | Makeup Artist |
| Laura Albert | Stunts |
| Michael Eaves | Digital Color Timer |
| Nerses Gezalyan | Foley Mixer |
| James Moriana | Foley Artist |
| Tom Bellfort | Supervising Sound Editor |
| Charlie Campbell | Art Department Coordinator |
| Mickey Giacomazzi | Utility Stunts |
| Aaron Haye | 3D Artist |
| Steve Ansell | Visual Effects Editor |
| Luca Kouimelis | Script Supervisor |
| Matthew I. Goldberg | Additional Production Assistant |
| Hallie D'Amore | Makeup Department Head |
| Lindsay Good | Art Department Assistant |
| Stephanie Hornish | Visual Effects Producer |
| Andy Ryan | Chief Lighting Technician |
| Marvin E. Lewis | Boom Operator |
| Toby Bronson | Key Set Costumer |
| James Lin | Location Manager |
| Lisa Fozzati | Assistant Location Manager |
| Greg Maloney | Compositing Supervisor |
| Daniel S. Irwin | Dialogue Editor |
| Sebastian Milito | Construction Coordinator |
| C.J. Maguire | Property Master |
| Patrick B. O'Brien | Camera Operator |
| Zade Rosenthal | Still Photographer |
| Amy Pawlowski | Digital Intermediate Editor |
| David Linck | Unit Publicist |
| Phil Pastuhov | Aerial Director of Photography |
| Alex Gibson | Supervising Music Editor |
| David Dozoretz | Visual Effects Supervisor |
| H. Mark Vuille | Gaffer |
| Greg Steele | ADR Mixer |
| Chris Jargo | ADR Editor |
| Cynthia E. Thornton | Assistant Editor |
| Victoria Wood | Wigmaker |
| Austin Cross | Lighting Technician |
| Andre Fenley | Assistant Sound Editor |
| J.R. Grubbs | Sound Effects Editor |
| Frank Dorowsky | Rigging Gaffer |
| Billy 'Jilly Bones' Jones | Scenic Artist |
| Lorene Simpson | Digital Intermediate Producer |
| Didier Levy | CG Supervisor |
| Lorenzo Hearns Jr. | Key Costumer |
| Bennett Andrews | Greensman |
| Kristen Davis | Set Designer |
| Jim Schwalm | Special Effects Coordinator |
| Jeri Baker | Hairstylist |
| Eddie Bydalek | Mix Technician |
| Catherine Childers | Key Hair Stylist |
| Beth Miller | Hair Department Head |
| Jeff Frost | Sculptor |
| Jim Martin | Production Illustrator |
| Susan Paley Abramson | Casting Assistant |
| Steve Burnes | Propmaker |
| Robert Mazaraki | Production Coordinator |
| Jenny Sandell | Assistant Production Coordinator |
| Kevin L. Jackson | Stunt Driver |
| Willie D. Burton | Production Sound Mixer |
| Ted Lubonovich II | Construction Foreman |
| Erin D. O'Connor | Visual Effects Production Assistant |
| Pete Anthony | Orchestrator |
| Pete Anthony | Conductor |
| Gregory Collis | Rigging Grip |
| Shane Buttle | Electrician |
| Robin Lynn Bonaccorsi | Stunt Double |
| Art Ford | Music Consultant |
| James Diggs | Standby Painter |
| Vincent Joseph Flaherty | Armorer |
| Darrin Denlinger | Storyboard Artist |
| Tom Martinek | Sequence Supervisor |
| Liz Matthews | Location Scout |
| Javier Arrieta | Costumer |
| Steven Cueva | Second Assistant Camera |
| Phil Bowen | Assistant Camera |
| Corinne Bogdanowicz | Digital Compositors |
| Gary Kangrga | Key Rigging Grip |
| Jason Inman | Set Medic |
| Alison Harstedt | Production Accountant |
| John Armstrong | Transportation Coordinator |
| Jamie Baxter | Matte Painter |
| Isabel Henderson | Post Production Supervisor |
| Peter Roderick | Construction Buyer |
| Steve Mann | Picture Car Coordinator |
| J. Michael Haynie | First Assistant Director |
| Peter Oktavec | Painter |
| Bryan Badman | Carpenter |
| Justine Hempe | Casting Associate |
| Darian Pollard | Music Arranger |
| Bart Barbuscia | Set Dressing Artist |
| Alison Cannon | Production Controller |
| Richard Mall | Key Grip |
| Chris Bustard | Additional Casting |
| Mark Sachen | Colorist |
| Bruce Schluter | Title Designer |
| Debbie Schwab | Production Supervisor |
| Bradford Ralston | Video Assist Operator |
| Daril Alder | Leadman |
| Emily Crupper | Set Decoration Buyer |
| Tony Olivieri | First Assistant Camera |
| Matthew J. Barden | Grip |
| Charmaine Nash Simmons | Costume Supervisor |
| Yaa Boaa Aning | Set Costumer |
| Thomas Garris | Driver |
| R. Ben Adams | Post Production Assistant |
| Kevin Berlandi | Set Production Assistant |
| Nathan Bailey | Stand In |
| Duane Kelly | Transportation Co-Captain |
| Dave Lopez | Sound Engineer |
| George Stevens | Visual Effects |
| Christopher Cram | Visual Effects Coordinator |
| David M. Kennedy | Technical Advisor |
| Jonathan Deiner | Production Secretary |
| Ralph Del Castillo | Dolly Grip |
| Maryellen Aviano | Extras Casting Coordinator |
| Brad Kenny | Extras Casting |
| Carol S. Federman | Assistant Makeup Artist |
| Rosi Gabl | Costume Illustrator |
| Chris Jensen | Digital Colorist |
| Martin Charles | Graphic Designer |
| Mimi N. McGreal | Travel Coordinator |
| John Bonnin | Libra Head Technician |
| Ryan Amborn | Special Effects Technician |
| Steve Battaglia | Second Assistant Director |
| Kristina M. Peterson | Second Second Assistant Director |
| Sandra Constantine | Assistant Accountant |
| Thomas Crawford | Second Company Grip |
| Justin Reeve | Music Coordinator |
| Brian Magerkurth | Sound Recordist |
| Eugene Davis | Additional Second Assistant Director |
| Tom Miller | Assistant Property Master |
| Yovel Schwartz | Location Assistant |
| Matthew Dillon Noonan | Location Production Assistant |
| Kari Mills | Extras Casting Assistant |
| Anne Scott | First Assistant Accountant |
| Ahmed Kirdar | Key Set Production Assistant |
| Lora Umphress | Payroll Accountant |
| Clyde Broom Jr. | Production Assistant |
| Jennifer Lobban | Second Assistant Accountant |
