 | Cailey Fleming als Bea |
 | Ryan Reynolds als Cal |
 | John Krasinski als Dad / Marshmallow (voice) |
 | Fiona Shaw als Grandmother |
 | Steve Carell als Blue (voice) |
 | Phoebe Waller-Bridge als Blossom (voice) |
 | Louis Gossett Jr. als Lewis (voice) |
 | Alan Kim als Benjamin |
 | Liza Colón-Zayas als Janet |
 | Bobby Moynihan als Jeremy |
 | Catharine Daddario als Bea’s Mom |
 | Audrey Hoffman als Bea (Ages 3 & 5) |
 | Laquet Sharnell Pringle als Receptionist |
 | Ed Herbstman als Deli Guy |
| Barbara Andres als Woman Upstairs |
| Alexander Rivero als Custodian |
 | Shauna Pinkett als Hospital Receptionist |
| Sa'Raya Paris Johnson als 7 Year-Old Girl |
| Marta Siteiya Moipei als Coffee Shop Barista |
| David Weissmann als Young Jeremy |
 | Awkwafina als Bubble (voice) |
 | Emily Blunt als Unicorn (voice) |
 | George Clooney als Spaceman (voice) |
 | Bradley Cooper als Ice (voice) |
 | Matt Damon als Flower (voice) |
 | Bill Hader als Banana (voice) |
 | Richard Jenkins als Art Teacher (voice) |
 | Keegan-Michael Key als Slime (voice) |
 | Blake Lively als Octocat (voice) |
 | Sebastian Maniscalco als Magician Mouse (voice) |
 | Christopher Meloni als Cosmo (voice) |
 | Matthew Rhys als Ghost (voice) |
 | Sam Rockwell als Guardian Dog (voice) |
 | Maya Rudolph als Ally (voice) |
 | Amy Schumer als Gummy Bear (voice) |
| Allyson Seeger als Viola (voice) |
 | Jon Stewart als Robot (voice) |
 | Brad Pitt als Keith (voice) |
| John Krasinski | Director |
| John Krasinski | Producer |
| John Krasinski | Writer |
| Allyson Seeger | Producer |
| Andrew Form | Producer |
| Ryan Reynolds | Producer |
| George Dewey | Executive Producer |
| Janusz Kamiński | Director of Photography |
| Michael Giacchino | Original Music Composer |
| Christopher Rouse | Editor |
| Andy Canny | Editor |
| John J. Kelly | Executive Producer |
| Jess Gonchor | Production Design |
| Louis Gossett Jr. | In Memory Of |
| Tricia Wood | Casting |
| Jennifer L. Smith | Casting |
| Mandy Moore | Choreographer |
| Alexa Ginsburg | Co-Producer |
| Kimberly Nelson LoCascio | Executive Producer |
| Jess Kidd | Co-Producer |
| Michael Lerman | Co-Producer |
| Jenny Eagan | Costume Design |
| Arslan Elver | Animation Supervisor |
| Chris Lawrence | Visual Effects Supervisor |
| Michael Lerman | First Assistant Director |
| Woodrow Travers | Second Assistant Director |
| Randy Manion | Unit Production Manager |
| John J. Kelly | Unit Production Manager |
| Mark Pettograsso | Stunt Coordinator |
| Kyle Woods | Stunt Coordinator |
| Mike Gunther | Stunt Coordinator |
| James Mather | Supervising Sound Editor |
| Mike Prestwood Smith | Sound Re-Recording Mixer |
| Mark Taylor | Sound Re-Recording Mixer |
| Brandon Proctor | Sound Re-Recording Mixer |
| Lee Salevan | Sound Re-Recording Mixer |
| Ethan Van der Ryn | Supervising Sound Editor |
| Erik Aadahl | Supervising Sound Editor |
| Jeff Robinson | Associate Producer |
| Lori Scowley | Associate Producer |
| Lori Scowley | Production Controller |
| Christopher J. Morris | Supervising Art Director |
| Kris Moran | Set Decoration |
| Zack Gonchor | Art Direction |
| Adam Mull | Set Designer |
| Mattie Siegal | Assistant Set Decoration |
| Ashley Wellbrock | Assistant Set Decoration |
| Timothy Metzger | Leadman |
| Matthew Moriarty | "A" Camera Operator |
| Matthew Moriarty | Steadicam Operator |
| Connie Huang | "B" Camera Operator |
| Lonny Danler | Digital Imaging Technician |
| Sean P. Gilbert | Underwater Camera |
| Meg Kettell | Second Unit Director of Photography |
| Brooke Satrazemis | Script Supervisor |
| Jay Rabinowitz | Additional Editing |
| Mark Fitzgerald | First Assistant Editor |
| Bryce Madden | Assistant Editor |
| Jordan Lindblad | Visual Effects Editor |
| Chris Clemente | Post Production Supervisor |
| David J. Schwartz | Sound Mixer |
| Graham Gardner | Boom Operator |
| Allison Howe | Boom Operator |
| Janek Finn Pfeffer | Boom Operator |
| Bruno F. Panacciulli | Construction Coordinator |
| Conrad V. Brink Jr. | Special Effects Supervisor |
| Jeff Brink | Special Effects Coordinator |
| Ken Robinson | Thanks |
| Curtis Green | Conductor |
| Curtis Green | Additional Music |
| Jeff Kryka | Orchestrator |
| Craig Crawford | Visual Effects Supervisor |
| Jeremy Beadell | Visual Effects Producer |
