 | Paul Rudd als Peter Klaven |
 | Jason Segel als Sydney Fife |
 | Rashida Jones als Zooey Rice |
 | Andy Samberg als Robbie Klaven |
 | J.K. Simmons als Oswald Klaven |
 | Jane Curtin als Joyce Klaven |
 | Jon Favreau als Barry |
 | Jaime Pressly als Denise |
 | Rob Huebel als Tevin Downey |
 | Thomas Lennon als Doug |
 | Sarah Burns als Hailey |
 | Lou Ferrigno als Lou Ferrigno |
 | Greg Levine als Hailey's Date |
 | Jean Villepique als Leanne |
 | Kym Whitley als Female Co-Worker |
| Colleen Crabtree als Female Co-Worker |
| Caroline Farah als Female Co-Worker |
 | Mather Zickel als Gil |
 | Aziz Ansari als Eugene |
 | Nick Kroll als Larry |
 | Liz Cackowski als Zooey's Friend |
 | Kulap Vilaysack als Zooey's Friend |
 | Catherine Reitman als Zooey's Friend |
 | Carla Gallo als Zooey's Friend |
 | Vicki Davis als Zooey's Friend |
 | Josh Cooke als Alan (Bench Press Guy) |
 | Jay Chandrasekhar als Barry's Buddy |
 | Seth Morris als Barry's Buddy |
| James P. Engel als Barry's Buddy |
 | Jerry Minor als Berry's Buddy |
 | Joe Lo Truglio als Lonnie (Voice Crack Guy) |
| Murray Gershenz als Mel Stein |
 | Keri Safran als JAR Waitress |
 | Greg Tuculescu als Open House Couple |
 | Ian Roberts als Venice Broadwalk Jogger |
 | Bob Cicherillo als Venice Boardwalk Bodybuilder |
 | Ethan S. Smith als Sidney's Buddy |
 | Nelson Franklin als Sidney's Buddy |
 | Ping Wu als Mr. Chu |
 | Jill Bartlett als Woman Leaving Sydney's House |
 | Matt Walsh als Impatient Golfer |
 | Geddy Lee als Geddy Lee - Rush |
 | Alex Lifeson als Alex Lifeson - Rush |
 | Neil Peart als Neil Peart - Rush |
 | Melissa Rauch als Woman Jogger Yelling at Sydney |
 | David Wain als Wedding Photographer |
| Raquel Bell als Saks Fifth Avenue Saleswoman |
 | Larry Wilmore als Justice Of The Peace |
| Dennis James Anderson als Hank Mardukas |
| Craig Wedren als Wedding Band |
| Damian Kulash als Wedding Band |
| Timothy Nordwind als Wedding Band |
| Dan Konopka als Wedding Band |
| Andy Ross als Wedding Band |
 | David Krumholtz als Sydney's Buddy (uncredited) |
 | Sidow Sobrino als Rush Concert Fan (uncredited) |
| John Hamburg | Director |
| John Hamburg | Screenplay |
| Larry Levin | Screenplay |
| Jake Rice | Post Production Supervisor |
| Luke Kalteux | Electrician |
| Lawrence Sher | Director of Photography |
| Larry Levin | Story |
| Donald De Line | Producer |
| John Hamburg | Producer |
| Bill Johnson | Executive Producer |
| Andrew Haas | Executive Producer |
| Ivan Reitman | Executive Producer |
| Tom Pollock | Executive Producer |
| Jeffrey Clifford | Executive Producer |
| Anders Bard | Co-Producer |
| Andrew Laws | Production Design |
| William Kerr | Editor |
| Leesa Evans | Costume Design |
| Allison Jones | Casting |
| Alex Daniels | Stunt Coordinator |
| Susan McNamara | Unit Production Manager |
| Scott Robertson | First Assistant Director |
| Jonas Spaccarotelli | Second Assistant Director |
| Eric Sundahl | Art Direction |
| Clint Wallace | Assistant Art Director |
| Christopher Carlson | Set Decoration |
| Daniel C. Gold | Camera Operator |
| Brooks Robinson | Camera Operator |
| Brooks Robinson | Steadicam Operator |
| Scott Garfield | Still Photographer |
| Diane H. Newman | Script Supervisor |
| Ken Segal | Production Sound Mixer |
| Andrew Adams | Boom Operator |
| Jarred Waldron | Chief Lighting Technician |
| Nate Johnson | Electrician |
| Hootly Weedn | Electrician |
| Glenn E. Moran | Rigging Gaffer |
| Daniel Boxer | Property Master |
| Michael Gaspar | Special Effects Supervisor |
| Richard Wood | Special Effects Coordinator |
| Trayce Gigi Field | Assistant Costume Designer |
| Suzanne Cranfill | Costume Supervisor |
| Molly Grundman-Gerbosi | Key Costumer |
| Ariel Gold | Key Costumer |
| Tracey Levy | Key Makeup Artist |
| Geri B. Oppenheim | Makeup Artist |
| Terrie Velazquez Owen | Key Hair Stylist |
| Matthew L. Kasten | Hairstylist |
| Peter J. Novak | Production Supervisor |
| Kate Kelly | Production Coordinator |
| Ben Harris | Casting Assistant |
| Heidi Falconer | Unit Publicist |
| Jennifer Lewicki | Art Department Coordinator |
| P. Scott Bailey | Set Dresser |
| Perry Batchelor | Set Dresser |
| Roxanne Brooks | Set Dresser |
| James Pollack | Set Dresser |
| Alan Baptiste | Set Dresser |
| Darrell Vangilder | Set Dresser |
| Dale DeStefani | Construction Coordinator |
| Gary Edelman | Transportation Coordinator |
| Vic Cuccia | Transportation Captain |
| Michael L. Sale | Additional Editing |
| Justin Bourret | First Assistant Editor |
| David Raymond | First Assistant Editor |
| Mitch Rosin | Assistant Editor |
| Darren King | Supervising Sound Editor |
| Marc Fishman | Sound Re-Recording Mixer |
| Adam Jenkins | Sound Re-Recording Mixer |
| Yann Delpuech | Sound Editor |
| Keith Bilderbeck | Sound Editor |
| Jeena M. Phelps | Sound Editor |
| Dan Yale | Sound Editor |
| Barbara Delpuech | Sound Editor |
| Ann Ducommun | Assistant Sound Editor |
| Justin Pearson | Assistant Sound Editor |
| E. Niles Klein | Assistant Sound Editor |
| Jennifer Hawks | Music Supervisor |
| Richard Ziegler | Music Editor |
| Gary Burritt | Negative Cutter |
| George Chavez | Color Timer |
| Peewee Piemonte | Stunts |
| Danielle Burgio | Stunt Double |
| Jonathan Arthur | Stunts |
| Theodore Shapiro | Original Music Composer |
