 | Rowan Atkinson als Johnny English |
 | Gillian Anderson als Pamela Thornton ("Pegasus") |
 | Dominic West als Simon Ambrose |
 | Rosamund Pike als Kate Sumner |
 | Daniel Kaluuya als Agent Colin Tucker |
 | Tim McInnerny als Patch Quartermain |
 | Pik-Sen Lim als Killer Cleaner |
 | Richard Schiff als Titus Fisher |
 | Burn Gorman als Slater |
 | Eric Carte als Agent One |
 | Roger Barclay als Agent Two |
 | Togo Igawa als Ting Wang |
 | Eleanor Wyld als Receptionist 1 |
 | Mandi Sidhu als Receptionist 2 |
 | Margaret Clunie als Receptionist 3 |
 | Mariella Frostrup als Royce (Voice) |
 | Miles Jupp als Technician |
 | Williams Belle als Ling |
 | Paul Che Biu-law als Chinese Man in Spectacles |
 | Courtney Wu als Man in Spectacles 2 |
 | Rupert Vansittart als Derek |
 | Isla Blair als Shirley |
 | Emma Vansittart als Margaret |
 | Christina Chong als Barbara |
 | Siu Hun Li als Chinese Susan |
 | Joséphine de la Baume als Madeleine |
 | Wale Ojo als President Chambal |
 | Mark Ivanir als Karlenko |
 | Chris Jarman als Michael Tembe |
 | Stephen Campbell Moore als Prime Minister |
 | Benedict Wong als Chi Han Ly |
 | Andrew Woodall als Foreign Secretary |
 | Lobo Chan als Xiang Ping |
 | Isabella Blake-Thomas als Izzie |
 | Janet Whiteside als Pamela's Mother |
| Maisie Fishbourne als Pamela's Toddler |
| Gary Kane als Matov |
 | Clara Paget als Waitress |
| Richard Syms als Man in Pinstripe |
 | Lily Atkinson als Girl with Crash Helmet |
 | Ellen Thomas als Tucker's Mum |
 | Ian Shaw als Agent Number Two |
| Oliver Zheng als Chinese Interpreter |
| Dave Holland als Man in Wheelchair |
| Oliver Parker | Director |
| William Davies | Writer |
| Jim Clay | Production Design |
| Stephen McLaughlin | Scoring Mixer |
| Stephen McLaughlin | Music Score Producer |
| Lucy Bevan | Casting |
| William Davies | Executive Producer |
| Chris Clark | Producer |
| Ronaldo Vasconcellos | Co-Producer |
| Guy Bensley | Editor |
| Eric Fellner | Producer |
| Beatrix Aruna Pasztor | Costume Designer |
| Nick Angel | Music Supervisor |
| Hamish McColl | Screenplay |
| Danny Cohen | Director of Photography |
| Graham Johnston | Makeup & Hair |
| Tim Bevan | Producer |
| Liza Chasin | Executive Producer |
| Debra Hayward | Executive Producer |
| Nicky Earnshaw | Production Manager |
| Sasha Harris | Unit Production Manager |
| Mark Hopkins | Second Assistant Director |
| Terry McShane | Third Assistant Director |
| Chiu Wah Lee | Line Producer |
| Tim Wellspring | Unit Production Manager |
| Dan Channing-Williams | Second Second Assistant Director |
| Gemma Louise Read | Third Assistant Director |
| Greg Tynan | Third Assistant Director |
| Robert Wade | Characters |
| Elle Crocker | Assistant Director |
| Alex Oakley | First Assistant Director |
| Cindy Yu | Second Assistant Director |
| Raphaël Benoliel | Line Producer |
| Soledad Bottaro | Line Producer |
| Kate Fasulo | Production Supervisor |
| James Chambers | Third Assistant Director |
| Ben Howarth | First Assistant Director |
| Ben Quirk | Third Assistant Director |
| Gareth Tandy | First Assistant Director |
| Ivan Lam | Unit Production Manager |
| Timur Karamolla | Assistant Director |
| Beatrice Manning | Second Assistant Director |
| Sekani Doram | Assistant Director |
| Doris Tse | Co-Producer |
| Cheng Wai-Kei | Third Assistant Director |
| Mark Gillespie | Third Assistant Director |
| Martin Kenzie | Second Unit Director |
| Tracey Warren | Second Assistant Director |
| Harriet Worth | Second Assistant Director |
| Cathy Doubleday | Script Supervisor |
| Neal Purvis | Characters |
| Scott Bunce | Second Assistant Director |
| Andrew McEwan | First Assistant Director |
| Kirsten Lane | Music Consultant |
| Paul Herbert | Stunt Coordinator |
| Mark Holding | Production Sound Mixer |
| Dan Whitty | Location Manager |
| Dominic Masters | Supervising Art Director |
| Glenn Freemantle | Supervising Sound Editor |
| Glenn Freemantle | Sound Designer |
| Caroline Smith | Set Decoration |
| Sallie Jaye | Makeup & Hair |
| René Adefarasin | First Assistant Camera |
| Jeremy Braben | Aerial Director of Photography |
| Peter Byrne | First Assistant "A" Camera |
| Abigail Catto | Second Assistant "A" Camera |
| Sebastian Cort | Camera Trainee |
| Steven Desbrow | Aerial Director of Photography |
| Adam Dorney | Second Assistant Camera |
| Simon Finney | Camera Operator |
| Max Glickman | Second Assistant Camera |
| Leigh Gold | First Assistant Camera |
| Giles Keyte | Still Photographer |
| Martin Kenzie | Second Unit Director of Photography |
| Oliver Loncraine | First Assistant "A" Camera |
| Tobias Marshall | Second Assistant Camera |
| Dan Morrison | Second Assistant Camera |
| Zac Nicholson | "A" Camera Operator |
| Zac Nicholson | Steadicam Operator |
| Luke Redgrave | "B" Camera Operator |
| Oliver Ward | Aerial Camera Technician |
| Jo McLaren | Stunts |
| Marc Mailley | Stunts |
| Ilan Eshkeri | Original Music Composer |
