 | Edward Norton als Will Graham |
 | Anthony Hopkins als Hannibal Lecter |
 | Ralph Fiennes als Francis Dolarhyde / Red Dragon |
 | Emily Watson als Reba McClane |
 | Harvey Keitel als Jack Crawford |
 | Philip Seymour Hoffman als Freddy Lounds |
 | Anthony Heald als Dr. Frederick Chilton |
 | Mary-Louise Parker als Molly Graham |
 | Tyler Patrick Jones als Josh Graham |
 | Ken Leung als Lloyd Bowman |
 | Frankie Faison als Barney Matthews |
 | Lalo Schifrin als Conductor |
 | John Rubinstein als Dinner Guest |
 | David Doty als Dinner Guest |
 | Brenda Strong als Dinner Guest |
 | Robert Curtis Brown als Dinner Guest |
 | Mary Anne McGarry als Dinner Guest |
 | Marc Abraham als Dinner Guest |
 | Veronica De Laurentiis als Dinner Guest |
 | Michael Cavanaugh als Forensic Dentist |
 | Madison Mason als Police Commissioner |
 | Bill Duke als Police Chief |
 | Azura Skye als Bookseller |
 | Stanley Anderson als Jimmy Price |
 | Jeanine Jackson als Dr. Hassler |
 | Ellen Burstyn als Grandma Dolarhyde (voice) (uncredited) |
 | Mary Beth Hurt als Museum Curator (uncredited) |
 | James Pickens Jr. als Male Zoo Doctor (uncredited) |
 | Frank Whaley als Ralph Mandy (uncredited) |
 | Tanya Newbould als Chromalux Secretary |
 | Katie Rich als Woman Detective |
| Alex Berliner als Photographer |
 | Tom Verica als Charles Leeds |
 | Marguerite MacIntyre als Valerie Leeds |
 | Elizabeth Dennehy als Beverly |
 | William Lucking als Byron Metcalf |
 | Joseph Simmons als Janitor |
 | Mark Moses als Father in Video |
 | Lisa Haley als Musician |
 | Lisa Thornhill als Mrs. Sherman |
| Ronald Fischer als Driver (uncredited) |
| Brett Ratner | Director |
| Martha De Laurentiis | Producer |
| Andrew Z. Davis | Executive Producer |
| Thomas Harris | Novel |
| Ted Tally | Screenplay |
| Mark Helfrich | Editor |
| Danny Elfman | Original Music Composer |
| Dante Spinotti | Director of Photography |
| Dino De Laurentiis | Producer |
| Keii Johnston | Stunts |
| James M. Freitag | Associate Producer |
| Steve Saklad | Art Direction |
| Lori Rowbotham | Assistant Art Director |
| Paul Sonski | Assistant Art Director |
| Karen O'Hara | Set Decoration |
| Patti McNulty | Art Department Coordinator |
| Francine Maisler | Casting |
| Kathy Driscoll-Mohler | Casting Associate |
| Betsy Heimann | Costume Design |
| Kristi Zea | Production Design |
| Conrad E. Palmisano | Stunt Coordinator |
| JoAnn Perritano | Unit Production Manager |
| James M. Freitag | First Assistant Director |
| Jonathan McGarry | Second Assistant Director |
| Andrea Mae Fenton | Assistant Set Decoration |
| J. Michael Muro | Camera Operator |
| J. Michael Muro | Steadicam Operator |
| Kim H. Ornitz | Production Sound Mixer |
| Mychal D. Smith | Boom Operator |
| Brad Einhorn | Property Master |
| Martin Kitrosser | Script Supervisor |
| Bac DeLorme | Second Second Assistant Director |
| Steve Maslow | Sound Mixer |
| Gregg Landaker | Sound Mixer |
| Lisa Rodgers | Post Production Supervisor |
| Jeffrey W. Petersen | Gaffer |
| Ken Pepiot | Special Effects Coordinator |
| Autumn Saville | Assistant Costume Designer |
| Julie L. Pearce | Makeup Department Head |
| Randy Westgate | Key Makeup Artist |
| Kelvin R. Trahan | Hair Department Head |
| Fríða Aradóttir | Hairstylist |
| Gregory King | Supervising Sound Editor |
| Darren King | Supervising Sound Editor |
| Craig Henighan | Sound Designer |
| Dan Yale | Foley Supervisor |
| Jeff Gomillion | ADR Mixer |
| Philip Rogers | ADR Recordist |
| Barbara Harris | ADR Voice Casting |
| Andy Malcolm | Foley Artist |
| Goro Koyama | Foley Artist |
| Ellen Segal | Music Editor |
| Ron Mellegers | Foley Mixer |
| Don White | Foley Mixer |
| Gary Burritt | Negative Cutter |
| Jim Passon | Color Timer |
| Gary Archer | Prosthetics |
| Steven Lambert | Stunts |
| Dick Ziker | Stunts |
| Barbara Anne Klein | Stunt Double |
| Denney Pierce | Stunts |
| Kurt D. Lott | Stunts |
| Brad Martin | Stunts |
| J.P. Romano | Stunts |
| Monica Staggs | Stunts |
| Harry Wowchuk | Stunts |
