 | Richard Gere als Dr. Alan Stone |
 | Peter Dinklage als Joseph |
 | Walton Goggins als Leon |
 | Bradley Whitford als Clyde |
 | Charlotte Hope als Becky |
 | Julianna Margulies als Ruth |
 | Kevin Pollak als Dr. Orbus |
 | James Monroe Iglehart als Benny |
 | Stephen Root als Dr. Rogers |
 | Jane Alexander als Dr. Abraham |
 | Julian Acosta als Dr. Francisco |
 | Danny Deferrari als Neil |
 | Chris Bannow als Louis |
 | Kathryn Leigh Scott als Victoria Rogers |
 | Christina Scherer als Carolyn |
 | Nancy Robinette als Mrs. Gabor |
 | Ripley Sobo als Molly |
 | Stina Kalman als Nurse |
 | George Aloi als Mental Patient |
 | Ava Gallucci als Shirley Stone |
 | Shade Rupe als Mental Patient |
 | Frankie Verroca als Schizophrenic Patient |
| Jon Avnet | Director |
| Kerry Johnson | Production Supervisor |
| Milton Rokeach | Book |
| Eric Nazarian | Writer |
| Jon Avnet | Writer |
| Jon Avnet | Producer |
| Annika Cassidy | Production Executive |
| Adam Epstein | Co-Executive Producer |
| Arianne Fraser | Executive Producer |
| Bill Haber | Executive Producer |
| Steven Haft | Executive Producer |
| Molly Hassell | Producer |
| Daniel Levin | Producer |
| Marsha Oglesby | Co-Executive Producer |
| Kip Pastor | Associate Producer |
| Delphine Perrier | Executive Producer |
| Stephanie Pon | Co-Producer |
| Jimmy Price | Line Producer |
| Robert Shapiro | Associate Producer |
| Aaron Stern | Producer |
| Max Tromba | Associate Producer |
| Glen Trotiner | Co-Producer |
| Jeff Russo | Original Music Composer |
| Denis Lenoir | Director of Photography |
| Patrick J. Don Vito | Editor |
| Richard Pagano | Casting |
| Stephanie Carroll | Production Design |
| Irfan Akdag | Art Direction |
| Aja Cooper | Set Decoration |
| Tere Duncan | Costume Design |
| Ruth Carsch | Key Hair Stylist |
| Jennifer Jefferson | Hairstylist |
| Alberto Machuca | Makeup Artist |
| Aaron F. Quarles | Hair Department Head |
| Julie Teel | Makeup Department Head |
| Enrique Vega | Hairstylist |
