 | Christopher Reeve als Dr. Alan Chaffee |
 | Kirstie Alley als Dr. Susan Verner |
 | Linda Kozlowski als Jill McGowan |
 | Michael Paré als Frank McGowan |
 | Meredith Salenger als Melanie Roberts |
 | Mark Hamill als Reverend George |
 | Pippa Pearthree als Sarah, George's Wife |
 | Peter Jason als Ben Blum |
 | Constance Forslund als Callie Blum |
 | Karen Kahn als Barbara Chaffee |
 | Thomas Dekker als David McGowan |
 | Lindsey Haun als Mara Chaffee |
 | Cody Dorkin als Robert |
| Trishalee Hardy als Julie |
| Jessye Quarry als Dorothy |
| Adam Robbins als Issac |
| Chelsea DeRidder Simms als Matt |
| Renee Rene Simms als Casey |
 | Danielle Keaton als Lily |
 | George Buck Flower als Carlton |
| Tony Haney als Dr. Bush |
| Ralph Miller als Village |
 | John Carpenter als Man at Gas Station Phone |
 | Seth Meyers als Trooper (uncredited) |
| John Carpenter | Director |
| David Himmelstein | Screenplay |
| John Wyndham | Novel |
| Andre Blay | Executive Producer |
| Shep Gordon | Executive Producer |
| Sandy King | Producer |
| Michael Preger | Producer |
| Ted Vernon | Executive Producer |
| Gary B. Kibbe | Director of Photography |
| Edward A. Warschilka | Editor |
| Dave Davies | Original Music Composer |
| John Carpenter | Original Music Composer |
| James Jacks | Co-Executive Producer |
| Robin Lynn Bonaccorsi | Stunts |
| David Chackler | Co-Producer |
| Sean Daniel | Co-Executive Producer |
| Reuben Cannon | Casting |
| Sandy King | Casting |
| Cheryl Miller | Casting |
| Rodger Maus | Production Design |
| Christa Munro | Art Direction |
| Robin Michel Bush | Costume Design |
| Don De Fina | Set Decoration |
| Rob Hinderstein | Special Effects Makeup Artist |
| Jeffrey Sudzin | Unit Production Manager |
| Charlotte Parker | Key Hair Stylist |
| Artist W. Robinson | First Assistant Director |
| James Bolt | Sound Re-Recording Mixer |
| Rick Alexander | Sound Re-Recording Mixer |
| Thomas Causey | Sound Mixer |
| John Dunn | Supervising Sound Editor |
| Bruno Van Zeebroeck | Special Effects Coordinator |
| Bruce Nicholson | Visual Effects Supervisor |
| Shane Dixon | Stunts |
| Lisa Dempsey | Stunts |
| Jon H. Epstein | Stunts |
| Bobby Bass | Stunts |
| Rocky Capella | Stunts |
| Hal Burton | Stunts |
| Kurt Bryant | Stunts |
| Troy Brown | Stunts |
| Eugene Collier | Stunts |
| Laura Dash | Stunts |
| Thomas DeWier | Stunts |
| Al Goto | Stunts |
| Paul Crawford | Stunts |
| Jeff Imada | Stunt Coordinator |
| Brian Imada | Stunts |
| Peter Lai | Stunts |
| Brad Lackey | Stunts |
| Billy D. Lucas | Stunts |
| Johnny Martin | Stunts |
| Mike Martinez | Stunts |
| Kevin Larson | Stunts |
| Jeff Mosley | Stunts |
| Jimmy Nickerson | Stunts |
| Alan Oliney | Stunts |
| Chuck Picerni Jr. | Stunts |
| Jim J. Poslof | Utility Stunts |
| Denney Pierce | Stunts |
| Mic Rodgers | Stunts |
| Arthur R. Botham | Second Unit Director of Photography |
| Benu Bhandari | Script Supervisor |
