 | Tim Curry als Wadsworth |
 | Eileen Brennan als Mrs. Peacock |
 | Madeline Kahn als Mrs. White |
 | Christopher Lloyd als Professor Plum |
 | Michael McKean als Mr. Green |
 | Martin Mull als Colonel Mustard |
 | Lesley Ann Warren als Miss Scarlet |
 | Colleen Camp als Yvette |
 | Lee Ving als Mr. Boddy |
 | Bill Henderson als The Cop |
 | Jane Wiedlin als The Singing Telegram Girl |
 | Jeffrey Kramer als The Motorist |
 | Kellye Nakahara als The Cook |
 | Will Nye als Cop #1 |
 | Rick Goldman als Cop #2 |
| Don Camp als Cop #3 |
 | Howard Hesseman als The Chief (uncredited) |
| John Landis | Story |
| Victor J. Kemper | Director of Photography |
| David Bretherton | Editor |
| John Morris | Original Music Composer |
| John Robert Lloyd | Production Design |
| Jonathan Lynn | Director |
| Debra Hill | Producer |
| Jon Peters | Executive Producer |
| Peter Guber | Executive Producer |
| Jonathan Lynn | Screenplay |
| George Folsey Jr. | Executive Producer |
| John Landis | Executive Producer |
| Jonathan Lynn | Story |
| Richard Haines | Editor |
| Eric Boyd-Perkins | ADR Supervisor |
| Cindy Baggett | Makeup Artist |
| Barbara Bruno | Second Second Assistant Director |
| Les Gobruegge | Set Designer |
| Donald B. Woodruff | Assistant Art Director |
| Cindy Folkerson | Stunts |
| Cate Bangs | Set Designer |
| Wilbur Finks | Swing |
| Gene Nollman | Set Designer |
| Lori Slomka | Other |
| Jean Malahni | Stunt Double |
| Rhio Haessig | Assistant Chief Lighting Technician |
| Kaye Pownall | Hairstylist |
| Brad Wilder | Makeup Artist |
| Jeffrey Chernov | Unit Production Manager |
| Walt Hadfield | Construction Coordinator |
| Steven Schwartz | Set Designer |
| Leslie Hoffman | Stunts |
| Terry Leonard | Stunt Coordinator |
| Bill McIntosh | Stunts |
| Jeffrey Chernov | Associate Producer |
| Rubin Andreatta | Greensman |
| Jim Stuebe | Boom Operator |
| Danny Costa | Stunts |
| Mario Zavala | Second Assistant Camera |
| James F. Walker | Construction Foreman |
| Gaylin P. Schultz | First Company Grip |
| John Yant | Grip |
| Michael Daves | First Assistant Director |
| Horst Grandt | Property Master |
| Eric Boyd-Perkins | ADR Editor |
| Harold Selig | Special Effects |
| Bill Roe | First Assistant Camera |
| Murphy Wiltz | Assistant Chief Lighting Technician |
| Sandy Robertson | Stunts |
| Michael Kaplan | Costume Design |
| William B. Major | Set Designer |
| Jeff Ramsey | Utility Stunts |
| Thomas L. Roysden | Set Decoration |
| John Hutchinson | Painter |
| Ronald C. Jacobs | Other |
| Gregg Landaker | Sound Re-Recording Mixer |
| Janet Hirshenson | Casting |
| Fred Throop | Props |
| Norval D. Crutcher | Supervising Sound Effects Editor |
| Samuel C. Crutcher | Supervising Sound Effects Editor |
| Jeannie Epper | Stunts |
| Joe Stone | Stunts |
| Bernie Schwartz | Dolly Grip |
| Alan B. Curtiss | Second Assistant Director |
| Mark P. Stoeckinger | Sound Effects Editor |
| Chere Rae | Stunts |
| John-Clay Scott | Stunts |
| Jane Jenkins | Casting |
| Hazel Catmull | Hairstylist |
| Edward Ternes | Makeup Artist |
| Tom Purser | Construction Foreman |
| John Tyrrell | Other |
| Anna Boorstin | Dialogue Editor |
| Robert L. Fisher | Stunts |
| Audie Aragon | Second Company Grip |
| Steve Gilbert | Other |
| Gary Ritchie | Sound Recordist |
| Vanessa Theme Ament | Foley Artist |
| Jean Malahni | Stunts |
| Eric D. Andersen | Camera Operator |
| Earl Gilbert | Chief Lighting Technician |
| Patrick Marshall | Other |
| Robbie Robinson | Still Photographer |
| Joseph F. Brennan | Boom Operator |
| Howard Neiman | Sound Effects Editor |
| Diane Cummings | Makeup Artist |
| David B. Cohn | Dialogue Editor |
| Lauren Palmer | ADR Editor |
| Laja Holland | Assistant Sound Editor |
| Oda Groeschel | Costumer |
| Thomas Causey | Sound Mixer |
| Michael Minkler | Sound Re-Recording Mixer |
| Calvin Joe Acord | Special Effects Coordinator |
| Al Contreras | Second Company Grip |
| Bitsy Gorman | Stand In |
| Sig Frohlich | Stand In |
| Norman Mont-Eton | Stand In |
| Craig Galloway | Other |
| Charmaine Nash Simmons | Costume Supervisor |
| Ken Harvey | Costumer |
| Robert Ross | Assistant Editor |
| Louis Demarco | Craft Service |
| Jack Hayes | Orchestrator |
| Lynn Harman | Transportation Captain |
| Randi Chernov | Producer's Assistant |
| Heidi Cohen | Production Assistant |
| Eugene Marks | Music Editor |
| Jeffrey Harstedt | Research Assistant |
| Sharre Jacoby | Production Assistant |
| Burke Mattsson | Title Designer |
| Carol Rosenthal | Producer's Assistant |
| Saul Kahan | Unit Publicist |
| Edward Lynn | Production Assistant |
| Beau Barthel | Assistant Editor |
| Doris Grau | Script Supervisor |
| Karen Penhale | Producer's Assistant |
| Dan Wallin | Scoring Mixer |
| Ellen Adolph | Other |
| Dan Goldwasser | Other |
| Eddie Lee Voelker | Transportation Coordinator |
| Mark Levine | Production Assistant |
| Susan Towner | Other |
