 | Sean Astin als Mikey Walsh |
 | Josh Brolin als Brand Walsh |
 | Jeff Cohen als Lawrence "Chunk" Cohen |
 | Corey Feldman als Clark "Mouth" Devereaux |
 | Kerri Green als Andy Carmichael |
 | Martha Plimpton als Stephanie "Stef" Steinbrenner |
 | Ke Huy Quan als Richard "Data" Wang |
 | John Matuszak als Sloth |
 | Robert Davi als Jake Fratelli |
 | Joe Pantoliano als Francis Fratelli |
 | Anne Ramsey als Mama Fratelli |
 | Lupe Ontiveros als Rosalita |
 | Mary Ellen Trainor als Mrs. Walsh |
 | Keith Walker als Mr. Walsh |
 | Steve Antin als Troy |
 | Paul Tuerpe als Sheriff |
 | George Robotham als Prison Guard |
| Charles McDaniel als Chunk's Father |
| Elaine Cohen McMahon als Chunk's Mother |
 | Michael Paul Chan als Data's Father |
| George Nicholas McLean als Mouth's Father |
 | Bill Bradley als Bill |
 | Jeb Stuart Adams als Troy's Friend #1 |
| Eric Briant Wells als Troy's Friend #2 |
 | Gene Ross als Man in Shower #1 |
| Max Segar als Man in Shower #2 |
| Newt Arnold als Man in Shower #3 |
| Jack O'Leary als Reporter #1 |
 | Patrick Cameron als Reporter #2 |
| Orwin C. Harvey als Tennis Player |
 | Ted Grossman als FBI Man |
 | Richard Donner als Policeman (uncredited) |
 | Eydie Faye als Eydie - Chunk's Older Sister (uncredited) |
| Rick Kuhn als Parent #3 (uncredited) |
 | Cyndi Lauper als Cyndi Lauper (archival footage) |
| Jennie Lew Tugend als Mrs. Wang (uncredited) |
| Lisa Quan als Data's Sister (uncredited) |
 | Curt Hanson als Mr. Perkins (as Curtis Hanson) |
| Harvey Bernhard | Producer |
| Nick McLean | Director of Photography |
| Richard Donner | Producer |
| Dave Grusin | Original Music Composer |
| Steven Spielberg | Executive Producer |
| Michael Kahn | Editor |
| Kathleen Kennedy | Executive Producer |
| Frank Marshall | Executive Producer |
| Chris Columbus | Screenplay |
| Richard Donner | Director |
| Paul Huston | Visual Effects |
| Stephen St. John | Camera Operator |
| Charles Saldaña | Key Grip |
| Steve LaPorte | Makeup Effects |
| Arthur F. Repola | Post Production Supervisor |
| Erik L. Nelson | Property Master |
| Marvin E. Lewis | Boom Operator |
| Willie D. Burton | Production Sound Mixer |
| J. Michael Riva | Production Design |
| John Reade | Transportation Coordinator |
| Betsy Norton | Script Supervisor |
| Riley 'Sean' Jones | Electrician |
| Richard L. Anderson | Supervising Sound Editor |
| Steven Spielberg | Story |
| William A. Barry III | Construction Foreman |
| Ruben Martinez | Craft Service |
| Robin S. Clark | Unit Production Manager |
| Tom Stern | Gaffer |
| Solange S. Schwalbe | Foley Editor |
| Eric Fiedler | Sculptor |
| Francis N. 'Lucky' Costello | Standby Painter |
| William P. Davis | Driver |
| Tim Palladino | Production Office Assistant |
| Fred Moshier | Transportation Captain |
| James Flamberg | Music Editor |
| Ed Ayer | Best Boy Electric |
| Carroll Johnston | Set Designer |
| John R. Shannon | Still Photographer |
| Jean Austin | Hairstylist |
| Andrew Bayer | Set Dressing Artist |
| Tony Amatullo | Location Manager |
| Michael J. McAlister | Visual Effects Supervisor |
| Malcolm Bryce | Lighting Technician |
| Jane Feinberg | Casting |
| Judy Taylor | Casting |
| Bobby Burns | Stunts |
| Michael J. Benavente | Sound Editor |
| Charlie Mullen | Animation Supervisor |
| Michael A. Chavez | First Assistant Camera |
| Tony Lloyd | Makeup Artist |
| George Robotham | Stunt Coordinator |
| Gil Haimsohn | Assistant Sound Editor |
| Dave Carson | Visual Effects Art Director |
| Mike Fenton | Casting |
| Rick Carter | Art Direction |
| Matt Sweeney | Special Effects Coordinator |
| Jack Johnson | Production Illustrator |
| Jane Goe | Production Accountant |
| Scott U. Adam | Unit Manager |
| Dan Pemberton | Propmaker |
| Dan Kolsrud | First Assistant Director |
| Joseph C. Nemec III | Assistant Art Director |
| Dan Ondrejko | Greensman |
| Donald F. Johnson | Sound Mixer |
| Linda DeScenna | Set Decoration |
| Richard La Motte | Costume Design |
| Robert Scaife | Construction Coordinator |
| Roger Gallo Garcia | Costume Supervisor |
| Mary Andrews | ADR Editor |
| Anthony Francesco | Second Assistant Camera |
| Patrick Cosgrove | Second Assistant Director |
| Else Blangsted | Supervising Music Editor |
| Michael Moore | Assistant Editor |
| Sharon Gerhard | Additional Second Assistant Director |
| David P. Newell | Assistant Property Master |
| Jennie Lew Tugend | Executive Assistant |
| Greg Orloff | Foley Mixer |
| Martin Rosenberg | Assistant Camera |
| Bonne Radford | Controller |
| John Roesch | Foley Artist |
| Warren Franklin | General Manager |
| William J. Foley | Swing |
| Christopher Gilman | Special Effects Assistant |
| Joe Hicks | Best Boy Grip |
| Barbara Brennan | Rotoscoping Artist |
| Arthur Baker | Music Producer |
| Diane Dankwardt | Assistant Accountant |
| Dave Grusin | Conductor |
| Patty Hughes | Production Secretary |
| Kim Marks | Visual Effects Camera |
| Bill Young | Dolly Grip |
| Donah Bassett | Negative Cutter |
| Steven Spielberg | Presenter |
| Doc D. Charbonneau | Stunt Double |
| Eric Smith | Best Boy Electric |
| Doc D. Charbonneau | Stunts |
| Denise Cheshire | Stunts |
| Laura Dash | Stunts |
| Sandra Lee Gimpel | Stunts |
| Spiro Razatos | Stunts |
| Jerry Riley | Stunts |
| John Robotham | Stunts |
| Marilyn Stader | Stunts |
| Paul Stader | Stunts |
| Desiree Szabo | Stunts |
| Russell Saunders | Stunts |
| J.P. Romano | Stunts |
| Carey Loftin | Stunts |
| Alex Sharp | Stunts |
| Randell Dennis Widner | Stunts |
| Victor Paul | Stunts |
| Richard Washington | Stunts |
| Kent Hays | Stunts |
| Richard Drown | Stunts |
| Cheryl E. Duncan | Stunts |
| Bob Herron | Stunts |
| Bob Harris | Stunts |
| Julie Johnson | Stunts |
| Lee Poppie | Stunts |
| Lila Finn | Stunts |
| Edward J. Ulrich | Stunts |
| Jodi Hovak | Stunts |
| James Herbert | Unit Production Manager |
| Michael D. O'Shea | Camera Operator |
| Horace Jordan | First Assistant Camera |
| Dale Allen Pelton | Assistant Art Director |
| Virginia Randolph-Weaver | Set Designer |
| Donald B. Woodruff | Set Designer |
| Víctor Pérez | Rigging Gaffer |
| Bruce D. Spellman | Best Boy Grip |
| Lisa Howard | Assistant Accountant |
| Rob Harris | Unit Publicist |
| Martin Cohen | Assistant Editor |
| Cyndi Lauper | Theme Song Performance |
