 | 91st Annual Christmas in Rockefeller Center (2023) als Self - Performer |
 | Goodbye Channel 99 (2023) als The Family Guy |
 | Pencils Vs Pixels (2023) als Self |
 | Gwen Stefanie | You Make It Feel Like Christmas (2017) als Self |
 | Barbra: The Music ... The Mem'ries ... The Magic! (2017) als Self (archive footage) |
 | Logan Lucky (2017) als Max Chilblain |
 | The Truth Is in the Stars (2017) als Self |
 | Sing (2016) als Mike (voice) |
 | TV's Funniest Animated Stars: A Paley Center for Media Special (2015) als Self / Stewie Griffin (voice) |
 | Sinatra 100: An All-Star Grammy Concert (2015) als Self |
 | Ted 2 (2015) als Ted (voice) |
 | Robot Chicken: Christmas Specials (2014) als Various (voice) (archive sound) |
 | Birdman or (The Unexpected Virtue of Ignorance) (2014) als Peter Griffin (voice) (archive footage) |
 | A Million Ways to Die in the West (2014) als Albert Stark |
 | Born Again Virgin Christmas Special (2013) als Santa Claus (voice) |
 | Starring Adam West (2013) als Himself |
 | Robot Chicken's ATM Christmas Special (2012) als Santa Claus (voice) |
 | Ted (2012) als Ted (voice) |
 | FOX 25th Anniversary Special (2012) als Self |
 | Seth MacFarlane: Swingin' in Concert (2011) als Himself |
 | Comedy Central Roast of Charlie Sheen (2011) als Himself - Roastmaster |
 | Angelina Ballerina: The Shining Star Trophy (2011) als Perry Parmesan (voice) |
 | Comedy Central Roast of Donald Trump (2011) als Self |
 | BBC Swingin' Christmas (2010) als Self - Performer |
 | Family Guy Presents: It's a Trap! (2010) als Peter Griffin as Han Solo / Stewie Griffin as Darth Vader / Brian Griffin as Chewbacca / Glenn Quagmire as C-3PO / Carter Pewterschmidt as Emperor Palpatine / Roger as Moff Jerjerrod / Tim the Bear as Wickett / Live Studio Ostrich / Pee-wee Herman (voice) |
 | Robot Chicken: Star Wars Episode III (2010) als Emperor Palpatine (voice) |
 | Family Guy Presents: Road to the North Pole (2010) als Peter Griffin / Brian Griffin / Stewie Griffin / Glenn Quagmire / Tom Tucker / Dr. Elmer Hartman / Captain Seamus / Carter Pewterschmidt / Additional Voices (voice) |
 | Comedy Central Roast of David Hasselhoff (2010) als Self - Roastmaster |
 | The Drawn Together Movie: The Movie! (2010) als I.S.R.A.E.L. (aka Intelligent Smart Robotic Animated Eraser Lady) (voice) |
 | Tooth Fairy (2010) als Ziggy |
 | The Simpsons 20th Anniversary Special - In 3D! On Ice! (2010) als Himself |
 | Family Guy Presents: Something, Something, Something, Dark Side (2009) als Peter Griffin as Han Solo / Brian Griffin as Chewbacca / Stewie Griffin as Darth Vader / Glenn Quagmire as C-3PO / Dr. Elmer Hartman as General Rieekan / Carter Pewterschmidt as Emperor Palpatine / Aaron Sorkin / Cookie Monster / Man / George Takei / Dagobah Man / Commander #2 / Driver / Ringo Starr / Empire Member #2 / Pilot #1 (voice) |
 | Dear Consumer (Robot Chicken's Full-Assed Christmas Special) (2009) als Santa Claus / Thor / Atheist Mayor (voice) |
 | Family Guy Presents: Seth & Alex's Almost Live Comedy Show (2009) als Self / Various (voice) |
 | Futurama: Into the Wild Green Yonder (2009) als Mars Vegas Singer (singing voice) |
 | Robot Chicken: Star Wars Episode II (2008) als Emperor Palpatine / Dr. Ball / Figrin D'an (voice) |
 | Hellboy: In Service of the Demon (2008) als Self |
 | A Very Special Family Guy Freakin' Christmas (2008) als Peter Griffin / Brian / Stewie / Quagmire / additional (voice) |
 | Hellboy II: The Golden Army (2008) als Johann Krauss (voice) |
 | Family Guy Presents: Blue Harvest (2008) als Peter Griffin as Han Solo / Brian Griffin as Chewbacca / Stewie Griffin as Darth Vader / Glenn Quagmire as C-3PO / Tom Tucker as Imperial Newscaster / Carter Pewterschmidt as Uncle Owen / Safeguard #1 / Italian #2 / White Guard #2 (voice) |
 | Robot Chicken's Half-Assed Christmas Special (2007) als Aslan / Hermey the Elf / Santa Claus / Narrator (voice) |
 | Family Guy Presents: Stewie Kills Lois and Lois Kills Stewie (2007) als Peter Griffin / Stewie Griffin / Stan Smith (voice) |
 | Robot Chicken: Star Wars (2007) als Emperor Palpatine (voice) |
 | Life Is Short (2006) als Dr. Ned |
 | Robot Chicken's Christmas Special (2005) als Hermey the Elf / Jesus Christ (voice) |
 | Family Guy Presents: Stewie Griffin: The Untold Story (2005) als Stewie Griffin / Various Characters (voice) |
 | American Dad!: The New CIA (2005) als Stan Smith / Roger (voice) |
 | Larry and Steve (1997) als Larry/Steve (voice) |
| | Return of the Sun Devil (1996) als Narrator (voice) |
 | The Life of Larry (1995) als Seth MacFarlane / Larry Cummings / Steve / Lois Cummings / Man in Underwear / Captain Kirk / Mr. Spock / Sulu / Ensign Skippee / British Man / Jeremy / Tom Hanks / Alex Trebek / Preacher / God (voice) |
