 | David Duchovny als Dr. Ira Kane |
 | Julianne Moore als Dr. Allison Reed, CDC |
 | Orlando Jones als Prof. Harry Phineas Block |
 | Seann William Scott als Wayne Grey |
 | Ted Levine als General Russell Woodman |
 | Ty Burrell als Colonel Flemming |
 | Ethan Suplee als Deke |
 | Michael Bower als Danny |
 | Dan Aykroyd als Governor Lewis |
 | Gregory Itzin als Cartwright |
 | Pat Kilbane als Officer Johnson |
 | Sarah Silverman als Denise |
 | Michelle Wolff als Carla |
 | Katharine Towne als Nadine |
 | Stephanie Hodge als Jill Mason |
 | John Cho als Student |
 | Steven Gilborn als Judge Guilder |
 | Wayne Duvall als Dr. Paulson |
 | Kyle Gass als Officer Drake |
 | Jerry Trainor als Tommy |
 | Jennifer Savidge als Clare |
 | Wendy Braun als Nurse Tate |
 | Michael Chapman als Sheriff Long |
 | Mary Pat Gleason als Customer |
 | Andrew Bowen als Road Worker |
 | Chris Wylde als Student |
 | Tom Woodruff Jr. als Lead Primate Creature (uncredited) |
 | Ashley Clark als Lt. Cryer |
| Jeff Apple | Executive Producer |
| David Rodgers | Executive Producer |
| Daniel Goldberg | Producer |
| Sheldon Kahn | Editor |
| Michael Chapman | Director of Photography |
| Don Jakoby | Screenplay |
| John Powell | Original Music Composer |
| Ivan Reitman | Director |
| Ivan Reitman | Producer |
| Tom Pollock | Executive Producer |
| Joe Medjuck | Producer |
| David Diamond | Screenplay |
| Wendy Greene Bricmont | Editor |
| David Weissman | Screenplay |
| Jeffrey Wilhoit | Foley |
| Eric Sundahl | Set Designer |
| Ben Woolverton | Leadman |
| Noelle King | Set Designer |
| Masako Masuda | Set Designer |
| Scott Martin Gershin | Sound Effects Editor |
| Dan Hegeman | Sound Effects Editor |
| Per Hallberg | Supervising Sound Editor |
| John-Paul Riva | Art Department Coordinator |
| Christopher Assells | Sound Effects Editor |
| Burt Dalton | Special Effects Coordinator |
| Eric Armstrong | Animation Supervisor |
| Walt Hadfield | Construction Coordinator |
| Tony Lamberti | Sound Effects Editor |
| Eric Reynolds | Animation Supervisor |
| Elaine L. Offers | Makeup Artist |
| Ken Wensevic | Makeup Artist |
| Eric Bruneau | CG Supervisor |
| Edward St. George | Hairstylist |
| Randy Kelley | Sound Effects Editor |
| Lauri Gaffin | Set Decoration |
| Margery Simkin | Casting |
| Richard F. Mays | Art Direction |
| Eric Leven | CG Supervisor |
| Aggie Guerard Rodgers | Costume Design |
| Colette Slattery | Hairstylist |
| Dennis S. Sands | Sound Re-Recording Mixer |
| Karen Baker Landers | Supervising Sound Editor |
| Laini Thompson | Makeup Artist |
| Bob Beemer | Sound Re-Recording Mixer |
| Matthew Bekoff | Set Designer |
| Scott Sanders | Sound Effects Editor |
| Scott Millan | Sound Re-Recording Mixer |
| Dino DiMuro | Sound Effects Editor |
| Phil Tippett | Visual Effects Supervisor |
| Des Carey | Visual Effects Editor |
| Lorenzo Hearns Jr. | Set Costumer |
| Kevin Rose-Williams | Visual Effects Editor |
| Mark Wendell | CG Supervisor |
| Ken Kokka | Visual Effects Producer |
| Thomas Robinson Harper | Stunt Coordinator |
| Peter G. Travers | CG Supervisor |
| Yuri Bartoli | Visual Effects Art Director |
| Don Howe | Animation Manager |
| Bunny Andrews | Music Editor |
| Mike Chambers | Visual Effects Producer |
| Jennifer Leo Russ | Visual Effects Editor |
| Jim Berney | Visual Effects Supervisor |
| Murray Close | Still Photographer |
| Saul Saladow | First Assistant Editor |
| Dave Robling | Transportation Coordinator |
| Dana E. Glauberman | First Assistant Editor |
| Daniel C. Gold | Camera Operator |
| Ron Goodman | Helicopter Camera |
| Winnie D. Brown | Costume Supervisor |
| Chanthou Kozberg | Set Costumer |
| David Luckenbach | Steadicam Operator |
| Kokayi Ampah | Location Manager |
| Yuri Bartoli | Creature Design |
| Crys Forsyth-Smith | Visual Effects Producer |
| Barbara Tuss | Script Supervisor |
| Peter J. Silbermann | Unit Publicist |
| Nancy St. John | Visual Effects Producer |
| Ian Fox | Additional Camera |
| Judith A. Cory | Hair Department Head |
| Karyn Huston | Key Hair Stylist |
| David F. Klassen | Supervising Art Director |
| Laura Graham | ADR Editor |
| Ken Chase | Key Makeup Artist |
| Chris Jargo | Supervising ADR Editor |
| Mark Irvin | Special Effects Supervisor |
| Jim Turner | Production Controller |
| Frank Roughan | Transportation Captain |
| Janet Lonsdale | Production Accountant |
| Steve Knisely | Location Scout |
| Curt Sobel | Temp Music Editor |
| David Dunbar | Rigging Grip |
| Michele Short | Casting Associate |
| Elizabeth Finch | Orchestrator |
| Betsy McClung | Sequence Leads |
| Trevor Loomis | First Assistant Camera |
| Jacob Chambers | Stunts |
| Phred Lender | Systems Administrators & Support |
| Brandon Crummett | Editorial Production Assistant |
| David J. Negron Sr. | Storyboard |
| Jim Alfonso | Driver |
| John Barnette | Set Medic |
| David Rosenthal | I/O Supervisor |
| Tim de Pala | Visual Effects Coordinator |
| Dennis Butterworth | Greensman |
| Thomas Meikle | Sculptor |
| Jon Crush | Stand In |
| Jude Jensen | Researcher |
| Mauriece Jacks Jr. | Video Assist Operator |
| Jay Galbo | Electrician |
| Todd Homme | Music Supervisor |
| Sheldon Kahn | Associate Producer |
| Bill 'Kauhane' Hoyt | Standby Painter |
| Paul Deason | Unit Production Manager |
| Ronell Venter | Associate Producer |
| Kevin Du Toit | Post Production Assistant |
| Paul Deason | Co-Producer |
| J. Michael Riva | Production Design |
| Steven Jetton | Layout |
| Clint Colver | Digital Compositors |
| Donald A. Spadoni | Rigging Gaffer |
| Angela Heald | Production Supervisor |
| Ken Schwenker | Associate Producer |
| Brian Bennett | Utility Stunts |
| Leslie Valentino | Production Coordinator |
| William B. Kaplan | Production Sound Mixer |
| John Clinton | Digital Producer |
| Leslie Ross | Painter |
| Marc Baird | Production Illustrator |
| Gavin Greenaway | Additional Music |
| Prentice Randolph | Carpenter |
| Alessandra Cave | Production Manager |
| Susan Deal | Craft Service |
| Larry Pausback | Best Boy Electric |
| Charles Rose | Lighting Supervisor |
| Helen Kozora | Set Decoration Buyer |
| Michael Denering | Scenic Artist |
| Jeff Porrello | Boom Operator |
| Melton C. Maxwell | Chief Lighting Technician |
| Tony Negrete | First Assistant Sound Editor |
| Sandy Williams | Key Grip |
| Michael Neumann | First Assistant Director |
| Terry Doherty | Set Dresser |
| Steve Wolfe | Camera Loader |
| Dieter Busch | Second Assistant Director |
| Diana Goodwin | Set Decorating Coordinator |
| George Doering | Musician |
| Steven Olds | Visual Effects Designer |
| Carol Demarti | Ager/Dyer |
| Alexi Saldamando | Casting Assistant |
| Paul Jyrälä | Foley Editor |
| Anthony Scott | CG Animator |
| Rick Colosimo | Grip |
| Cliff Fleming | Aerial Coordinator |
| Gary Burritt | Negative Cutter |
| Carlos Rosario | Costume Illustrator |
| Ray Felipe | Script Researcher |
| Philip D. Morrill | Assistant Sound Editor |
| David Schneider | Utility Sound |
| Bruce Benson | Pilot |
| Bryan D. Garofalo | Assistant Property Master |
| Renan Galindo | Lighting Technician |
| Alan Shultz | Dolly Grip |
| Bryan Fletchall | Techno Crane Operator |
| Lauren Stephens | Dialogue Editor |
| Hope M. Parrish | Property Master |
| Laura Harris Atkinson | Dialogue Editor |
| Kimaree Long | Dialogue Editor |
| Michelle Pazer | ADR Editor |
| Chris Hogan | Dialogue Editor |
| Fred Peck III | Sound Recordist |
| Jim McVay | Compositing Supervisor |
| Nina Saxon | Title Designer |
| Kofi Elam | Stunt Double |
| Thomas Krebs | Visual Effects Assistant Editor |
| Karen Jine | Visual Effects Production Assistant |
| Daniel Myers Boone | Payroll Accountant |
| Greg Steele | ADR Mixer |
| Greg Zimmerman | Foley Recordist |
| Andy Hill | Music Consultant |
| Rodney Sandoval | Second Assistant Camera |
| Anthony Harris | Digital Color Timer |
| Rhonda Baer | Assistant Location Manager |
| Claudia Bonfe | Art Department Production Assistant |
| Angie Ryan | Second Assistant Accountant |
| Lonnie Leslie | Best Boy Grip |
| Deborah Thomas | Data Wrangler |
| Chuck Sharp | Assistant Chief Lighting Technician |
| Steven R. Molen | Production Executive |
| Liz Borges-Herzog | Production Assistant |
| Eric Ramsey | Storyboard Artist |
| Tony Hobbs | Extras Casting |
| Kenneth Roth | Additional Second Assistant Director |
| Nerses Gezalyan | Foley Mixer |
| Anna Solorio-Catalano | Assistant Editor |
| Francis Meade Warner | Assistant Production Coordinator |
| Lance Gilmer | Special Effects Technician |
| Dana McCall | On Set Dresser |
| Daniel Kuehn | Visual Effects Production Manager |
| Howard Berger | Effects Supervisor |
| Candice Dobkousky | Costumer |
| James Moriana | Foley Artist |
| David Luckenbach | First Assistant "B" Camera |
| Alonzo Ruvalcaba | Head of Production |
| Michael Strong | Key Rigging Grip |
| Jorge Agraz | Production Secretary |
| Primrose Fukuchi | Assistant Accountant |
| Sonia Bhalla | Second Second Assistant Director |
| Christopher Allen Nelson | Special Effects Makeup Artist |
| Debbie Evans | Utility Stunts |
| Troy Gilbert | Utility Stunts |
| Eurlyne Epper | Utility Stunts |
| Annie Ellis | Utility Stunts |
| Troy Brown | Utility Stunts |
| Freddie Hice | Utility Stunts |
| Donna Evans | Utility Stunts |
| Oakley Lehman | Stunts |
| Janet Brady | Utility Stunts |
| Mic Rodgers | Utility Stunts |
| Erik Rondell | Stunt Double |
| Joanna Shelmidine | Stunt Double |
| Joe Bucaro III | Stunts |
| Keith Campbell | Utility Stunts |
| Tom Elliott | Utility Stunts |
| Tim Rigby | Utility Stunts |
| Cinda-Lin James | Stunt Double |
| Tommy J. Huff | Utility Stunts |
