 | Milla Jovovich als Alice |
 | Sienna Guillory als Jill Valentine |
 | Michelle Rodriguez als Rain Ocampo |
 | Aryana Engineer als Becky |
 | Li Bingbing als Ada Wong |
 | Boris Kodjoe als Luther West |
 | Kevin Durand als Barry Burton |
 | Johann Urb als Leon S. Kennedy |
 | Robin Kasyanov als Sergei |
| Ofilio Portillo als Tony |
 | Oded Fehr als Todd / Carlos |
 | Colin Salmon als James 'One' Shade |
 | Shawn Roberts als Albert Wesker |
 | Megan Charpentier als The Red Queen |
 | Takato Yamashita als Japanese Businessman |
 | Mika Nakashima als J Pop Girl |
 | Ray Olubowale als The Axe Men |
 | Hiroo Minami als Tokyo Zombie (uncredited) |
| Paul W. S. Anderson | Writer |
| Steve Shewchuk | Set Decoration |
| Wendy Partridge | Costume Design |
| Kevin Phipps | Production Design |
| Alexander Dostal | Producer |
| Martin Moszkowicz | Executive Producer |
| Niven Howie | Editor |
| Deirdre Bowen | Casting |
| Paul W. S. Anderson | Producer |
| Jeremy Bolt | Producer |
| Paul W. S. Anderson | Director |
| Don Carmody | Producer |
| Hartley Gorenstein | Line Producer |
| Dennis Davenport | Art Direction |
| Dan Yarhi | Art Direction |
| Glen MacPherson | Director of Photography |
| VFx Star | Visual Effects |
| Jatinder Singh Manhas | Visual Effects |
| Bob Gilles | Steadicam Operator |
| J.C. Cuthbert | Art Department Coordinator |
| Steve Bryant | Assistant Property Master |
| Leslie Whitaker | Best Boy Electric |
| Jamieson Shaw | Camera Trainee |
| Edward Mikolic | Gaffer |
| Jason Edwardh | Animation Supervisor |
| Christopher Richards | Casting Associate |
| Kevin Murphy | Swing |
| Kevin Jewison | Camera Operator |
| Kimberley Smith | Camera Trainee |
| Marlene Aarons | Assistant Makeup Artist |
| Patricia Medina | Assistant Hairstylist |
| Andrew Yurkiv | Carpenter |
| Etienne Gravrand | Set Designer |
| Doug Graham | Swing |
| Bill McShane | Best Boy Grip |
| Amber Chase | Prosthetic Makeup Artist |
| Allan Cooke | Prosthetic Makeup Artist |
| Anthony Veilleux | Prosthetic Makeup Artist |
| Tommy Vance | Carpenter |
| Krystian Bedharski | Dolly Grip |
| Akira Nishihata | First Assistant "A" Camera |
| Carol Hartwick | Assistant Hairstylist |
| Peter Raponi | Carpenter |
| Marko Willis | Rigging Grip |
| Tim Davis | Video Assist Operator |
| Alex Kavanagh | Assistant Costume Designer |
| Francine St. Onge | Contact Lens Technician |
| Shane Zander | Prosthetic Makeup Artist |
| Rudy Katkic | Camera Operator |
| Trevor Lawley | Digital Imaging Technician |
| Madeleine Stewart | Assistant Costume Designer |
| Zane Knisely | Prosthetic Makeup Artist |
| Jeff Poulis | Assistant Property Master |
| Mehran Salamati | Director of Photography |
| Tracy Shaw | Dolly Grip |
| Patrick Krauter | Dolly Grip |
| Dean Stinchcombe | First Assistant "A" Camera |
| Bob Poole | Generator Operator |
| Robert Van Campenhout | Rigging Grip |
| Rick Leger | Techno Crane Operator |
| Fina Khan | Assistant Hairstylist |
| Paul Macina | Head Carpenter |
| Kerry Spurrell | Property Buyer |
| Kevin Barnes | Best Boy Electric |
| Anatoliy Neznanov | Gaffer |
| Chris Stagg | Grip |
| Dave Ferguson | Key Grip |
| Stephanie Lees | Costume Supervisor |
| Ron Renzetti | Dolly Grip |
| Alistair Dempsey | Dolly Grip |
| Wilton Higgins | Grip |
| David Pamplin | Rigging Grip |
| Tania Etienne | Seamstress |
| Tom Toop | Carpenter |
| Charles McGlynn | Property Master |
| Rick Moran | Swing |
| Marc Purdy | Grip |
| Janice Skinner | Seamstress |
| Mario Cacioppo | Assistant Makeup Artist |
| Sandra Wheatle | Key Makeup Artist |
| Christina Smith | Makeup Artist |
| Jo-Ann MacNeil | Makeup Department Head |
| Ed Dudnik | Carpenter |
| Tory Bellingham | Property Master |
| Sylvain Bombardier | Set Designer |
| Keith Murphy | Camera Operator |
| Vinit Borrison | Digital Imaging Technician |
| Michael Carr | First Assistant "B" Camera |
| William Ng | Key Costumer |
| Ian Worling | Carpenter |
| Bill Vance | Head Carpenter |
| Emerson Doerksen | Sculptor |
| Patricia Larman | Set Decoration Buyer |
| Stan Smetaniuk | Generator Operator |
| Jim Holmes | Best Boy Grip |
| Ryan Myler | Camera Trainee |
| Chirayouth Jim Saysana | First Assistant "B" Camera |
| Daniel Edwards | Casting Assistant |
| Rita Pacitto | Key Hair Stylist |
| Graham Chivers | Prosthetic Makeup Artist |
| Blaine Twyne | Carpenter |
| Dan Wladyka | Leadman |
| Evan Webber | Set Designer |
| Paul Vilchur | Camera Trainee |
| David Allen | Gaffer |
| John Irwin | Generator Operator |
| Jesse Stanley | Key Grip |
| Walter Lipscombe | Key Rigging Grip |
| Nikki Holmes | Rigging Gaffer |
| Michael L. Hall | Gaffer |
| Jason Lenoury | Rigging Grip |
| Jeff DaSilva | Second Assistant "A" Camera |
| Victoria McKay | Seamstress |
| Hugh McJanet | Best Boy Electric |
| Vern Nobles | Second Unit Director of Photography |
| Jamie Hodgson | Generator Operator |
| Jayden York | Libra Head Technician |
| Ron Schroeder | Rigging Grip |
| Julia Seidman | Second Assistant "B" Camera |
| Rose-Mary Gubala | Assistant Makeup Artist |
| Robert Stecko | Camera Operator |
| Craig Campbell | Rigging Grip |
| Rafy | Still Photographer |
| Vincent Sullivan | Hair Department Head |
| Kirk Cheney | Construction Coordinator |
| Marina Reshetnikova | Sculptor |
| Cheryl Junkin | Swing |
| Andrey Schtaff | Key Grip |
| Hugh Brule | Rigging Grip |
| Jeff Laidlaw | Carpenter |
| Tony Parkin | Construction Coordinator |
| Ryan Czyzewski | Digital Imaging Technician |
| Andrew Caney | Grip |
| Elliot Benjamin | Rigging Grip |
| Federico De Marco | Second Assistant "A" Camera |
| Sarah Warland | Second Assistant "B" Camera |
| Thomas Hayek | Sound Mixer |
| Andy Deygoo | 3D Artist |
| Branko Basarovski | CG Artist |
| Andrew K. Thompson | Compositing Artist |
| Ian Britton | Compositing Supervisor |
| Barb Benoit | Digital Compositor |
| Perrine Michel | Digital Compositor |
| Becca Donohoe | Visual Effects Coordinator |
| Joel Thompson | Visual Effects Editor |
| Chris Nokes | Visual Effects Production Manager |
| Al Vrkljan | Armorer |
| Diane Pitblado | Dialect Coach |
| Susan Marucci | Script Supervisor |
| Jared Barber | Animation |
| Kyle Yoneda | CG Supervisor |
| Shervin Shoghian | Compositing Supervisor |
| Kristy Blackwell | Digital Compositor |
| Kyle Sim | Digital Compositor |
| Jon Cowley | Visual Effects Supervisor |
| Matthew Robitaille | Craft Service |
| Katja Kessler | Legal Services |
| Igor Sushevskiy | Production Coordinator |
| Grant Boyle | Set Production Assistant |
| Craig Baker | Boom Operator |
| Steve Baine | Foley Artist |
| Stephen Barden | Supervising Sound Editor |
| Matthew Lajoie | Animation |
| Andre Brizard | Compositing Artist |
| Briana Nuttall | Digital Compositor |
| Mike Portoghese | Digital Compositor |
| Annie Normandin | Digital Effects Producer |
| Naomi Foakes | Visual Effects Coordinator |
| Laurie Kerr Jones | Visual Effects Producer |
| Vazgen Hachatryan | Production Assistant |
| Craig Seitz | Set Production Assistant |
| Mark Rodziewicz | 3D Artist |
| Chris Johnson | 3D Supervisor |
| Greg Lamar | Digital Compositor |
| Steve Elliott | Visual Effects Coordinator |
| Colin McLellan | ADR Recordist |
| Peter Persaud | Foley Recordist |
| Andrew Tay | Sound Re-Recording Mixer |
| Scott Riopelle | Compositing Supervisor |
| Ashlesh Kotangale | Compositor |
| Rob Del Ciancio | Compositor |
| Andrew Brooks | Digital Compositor |
| Mark Thomas-Stubbs | Digital Compositor |
| Gary Couto | Digital Compositor |
| Anna Joukova | Digital Compositor |
| Jonathan Piche-Delorme | Digital Effects Supervisor |
| Lorraine Proctor | First Assistant Accountant |
| Marsha Metz | Legal Services |
| Karen Doble | Production Coordinator |
| Min Young Kim | 3D Artist |
| Chris Arnott | CG Artist |
| Alex Llewellyn | Compositing Lead |
| Alex Branton | Digital Compositor |
| Adam Potvin | Digital Compositor |
| Kyle Boylen | Digital Compositor |
| Terry Rose | Visual Effects Compositor |
| Jo Hughes | Visual Effects Producer |
| Sarah Cauchois | Visual Effects Producer |
| Aaron Horton | Assistant Production Coordinator |
| Martin Hesselink | Animation |
| Jorge Sanchez | CG Artist |
| Janis Vaitilavics | CG Artist |
| Felix Serwir | Compositing Artist |
| Christopher Courtland | Compositor |
| Stephen Robertson | Compositor |
| Lorne Kwechansky | Lighting Artist |
| Tom Turnbull | Sequence Supervisor |
| Dave McGhie | Visual Effects Compositor |
| Brandon Schaafsma | Visual Effects Coordinator |
| Michael DiCarlo | Visual Effects Coordinator |
| Megan Shaw | Legal Services |
| Jessica Olivia Pillar | Production Office Assistant |
| Aishleen McCann | Production Secretary |
| Karen Pidgurski | Unit Publicist |
| Alex Bullick | Sound Effects Editor |
| Bryan Davies | CG Artist |
| Dominic Remane | CG Supervisor |
| Greg Astles | Digital Compositor |
| Mattaniah Yip | Digital Compositor |
| Dennis Berardi | Visual Effects Supervisor |
| Marc Jouveneau | Visual Effects Supervisor |
| Paul Cafferty | Post Production Accountant |
| Tom Nagy | Animation |
| Andy Hunter | Visual Effects Compositor |
| Emily Buller | Visual Effects Producer |
| Charles Taylor | Armorer |
| Evgenii Chetveryakov | Production Assistant |
| Stas Novak | Production Assistant |
| Jerome Persaud | Production Office Assistant |
| Margaret Tanod | Script Supervisor |
| John J. Thomson | Sound Mixer |
| Mark Zsifkovits | Sound Re-Recording Mixer |
| Carlos Miras Sepulveda | Compositing Artist |
| Michelle Yu | Compositor |
| Matthew Dochstader | Compositor |
| James Cooper | Digital Compositor |
| Eddee Huang | Digital Compositor |
| Brendan Taylor | Digital Compositor |
| Tracey Vaz | Digital Compositor |
| Eric Robinson | Digital Effects Supervisor |
| Ken Dhaliwal | Legal Services |
| Bob Tarantino | Legal Services |
| James F. Breithaupt | Production Accountant |
| Wiebke Döhla | Publicist |
| Jill Purdy | Dialogue Editor |
| Brian Dignadice | 3D Artist |
| Salvador Zalvidea | Compositing Artist |
| Kumar Umesh | Digital Compositor |
| Robert Greb | Digital Compositor |
| Jeremy Johnson | Digital Compositor |
| Matt Glover | Visual Effects Coordinator |
| Adam Jewett | Visual Effects Production Manager |
| Paul Capuano | Dolby Consultant |
| Paul Ducker | CG Artist |
| Paul DeOliveira | Digital Compositor |
| Jay Stanners | Digital Compositor |
| Sarah Barber | Visual Effects Coordinator |
| J.P. Giamos | Visual Effects Coordinator |
| Daniela Saioni | Continuity |
| Samantha Kates | Craft Service |
| Andrew Stirk | Sound Re-Recording Mixer |
| Joseph Cheng Chen | Animation |
| Tie David Gambacurta | Animation |
| Tong Zhou | CG Artist |
| Ethan Lee | CG Supervisor |
| Michael Hatton | Digital Compositor |
| Geoff Marshall | Lighting Artist |
| Ram Ravichandran | Lighting Artist |
| Sergey Shlyaev | Lighting Artist |
| Thomas Grant Morrison | Lighting Artist |
| Kelly Noordermeer | Visual Effects Editor |
| Stefan Steen | Production Coordinator |
| Robert Gardiner | Set Production Assistant |
| Matthew McKenzie | ADR Recordist |
| Rose Gregoris | First Assistant Sound Editor |
| Andrew Lawson | CG Artist |
| Lucian Boicu | Digital Compositor |
| Max Piersig | Digital Compositor |
| Clifford Otomi Green | Lighting Artist |
| Livio Passera | Lighting Supervisor |
| Chris Ross | Visual Effects Coordinator |
| Alan Zielonko | Boom Operator |
| Ariel Joson | 3D Artist |
| Kevin Vriesinga | Animation |
| Dan Rankin | CG Artist |
| Jeremy Séguin | Compositing Artist |
| Corey Coates | Compositor |
| Diego Piccinato | Compositor |
| Marco Lee | Digital Compositor |
| Tony Cybulski | Digital Compositor |
| Jessica Lister | Craft Service |
| Eric Apps | ADR Recordist |
| Terence Krueger | 3D Artist |
| Ian MacLeod | 3D Artist |
| Giorgio Marino | Compositing Artist |
| Greg Behrens | Visual Effects Producer |
| Dave Muscat | Digital Intermediate |
| John Bardswich | Digital Intermediate |
| Berenicci Hershorn | Assistant Editor |
| Caitlin Dowbiggin | Post Production Assistant |
| Brett Chan | Stunt Coordinator |
| Kevin Downer | Digital Intermediate |
| Mark Stevens | Digital Intermediate |
| Nick Powell | Fight Choreographer |
| J.R. Kenny | Special Effects Technician |
| Gary Kleinsteuber | Pyrotechnic Supervisor |
| Adam Gagnon | Digital Intermediate Editor |
| Emma Sanders Finlayson | Post Production Coordinator |
| Tony Kenny | Special Effects Coordinator |
| Alison Schouten | Digital Intermediate |
| Mark Lawton | Special Effects Supervisor |
| Hudson Kenny | Special Effects Technician |
| Dawn M. Stoliar | First Assistant Editor |
| Peter Armstrong | Digital Intermediate |
| Jonathan Matthews | Location Manager |
| Eugene Trubetskoy | Location Manager |
| Kôichi Funayama | Stunts |
| Joanne Leach | Stunt Double |
| Andy Milburn | Original Music Composer |
| Tom Hajdu | Original Music Composer |
| Robert Johnson | Key Grip |
| Alicia Turner | Stunt Double |
| Rorelee Tio | Stunt Double |
| Mitra Suri | Stunt Double |
| Mary Ann Stevens | Stunts |
| Ilora Rosenberg | Stunts |
| Alison Reid | Stunts |
| Angelica Lisk-Hann | Stunts |
| Liise Keeling | Stunts |
| Corry Glass | Stunt Double |
| Marie-Ève Beckers | Stunts |
| Lisa Marra | Second Assistant Accountant |
| Brian Law | Video Assist Operator |
| Doug Chapman | Stunts |
| tomandandy | Music |
| Jamie Christopher | First Assistant Director |
| Jodi Stecyk | Stunts |
| Matthew Sharp | Assistant Director |
