 | Andy Samberg als Jose Canseco |
 | Akiva Schaffer als Mark McGwire |
 | Jorma Taccone als Joe Montana / Walt Weiss / Reporter |
 | Hannah Simone als Amber |
 | Jenny Slate als Stacy |
 | Sterling K. Brown als Sia |
 | Jim O'Heir als Puka Shell Bob |
 | Maya Rudolph als Val Gal #5 |
 | Stephanie Beatriz als Val Gal #1 |
 | Este Haim als Val Gal #3 |
 | Alana Haim als Val Gal #2 |
 | Danielle Haim als Val Gal #4 |
 | Whitney Moore als Snow Bunny |
 | Dave Faulkner als Mark's Dad |
| Ben Perez als Jose's Dad |
 | Dan Wicksman als Maitre D' |
| Denise Weintraub als Mark's Mom |
| Trinity Chanel als Madonna |
| Sis Gold als Mrs. MicGillicutty |
| Kyla Billings als Bikini Babe |
| Britta Grant als Bikini Babe |
 | Jonetta Kaiser als Bikini Babe |
 | Julia Nolan als Bikini Babe |
 | Jeff Torres als Lenny the Torso |
 | Ryan Nemeth als Hunky Reporter |
 | Tory Taranova als Reporter |
| Akiva Schaffer | Editor |
| Mike Diva | Editor |
| Akiva Schaffer | Director |
| Mike Diva | Director |
| Aaron Grasso | Director of Photography |
| Becky Sloviter | Executive Producer |
| Jeni Novak | Makeup Artist |
| Terry Watson | Production Design |
| Jorma Taccone | Executive Producer |
| Andy Samberg | Executive Producer |
| Laci Simon | Makeup Artist |
| Akiva Schaffer | Executive Producer |
| Tara Loren | Makeup Department Head |
| Heather Allison | Costume Design |
| Marissa Alanis | Associate Producer |
| Sacha Ben Harroche | Co-Executive Producer |
| Alexis Celic | Co-Executive Producer |
| Avtar Khalsa | Co-Executive Producer |
| Michael Sagol | Co-Executive Producer |
| Shyam Sengupta | Co-Executive Producer |
| Josh Shadid | Co-Executive Producer |
| Malcolm Wax | Line Producer |
| Dan Packer | Editor |
| Brandon Allen | Set Decoration |
| Hilary Bauman | Set Decoration |
| Nina Roxanne | Assistant Makeup Artist |
| Michelle Del Mese | Production Manager |
| Robin Phillips | Post Production Supervisor |
| Joshua Gegen | Second Assistant Director |
| Andy Morris | First Assistant Director |
| Bryan Forrest | Armorer |
| Bryan Forrest | Weapons Master |
| Hunter Gorton | Property Master |
| Tony Swatton | Weapons Master |
| Jason Smith | Set Dresser |
| Jordan Kevin Allen | Rotoscoping Artist |
| Maxwell Blum | Visual Effects Compositor |
| Ben Forman | Sound Mixer |
| Craig Mann | Sound Re-Recording Mixer |
| Kevin Senzaki | Sound Designer |
| Laura Wiest | Sound Re-Recording Mixer |
| Marbella Calvillo | Visual Effects Compositor |
| Arthur Castillo | Visual Effects Compositor |
| Ethan Chancer | 3D Artist |
| Ethan Chancer | Compositing Lead |
| Nickolaas DenBoer | 3D Artist |
| Peter France | 3D Artist |
| Jeb Hardwick | Visual Effects Compositor |
| Javier Saenz Ituarte | 3D Artist |
| Josh Johnson | Compositing Lead |
| Joshua James Johnson | Compositing Lead |
| Daniel Labrado | 3D Artist |
| Morten Lasskogen | 3D Artist |
| Kenson Lee | Visual Effects Compositor |
| Kial Natale | 3D Artist |
| Aaron Nelson-Purcell | Rotoscoping Artist |
| David Niednagel | Visual Effects Compositor |
| Calvin Serrano | 3D Artist |
| Vincent Viriot | 3D Artist |
| Alec Ernest | Digital Imaging Technician |
| Gordan Hale | Best Boy Electric |
| Mike Jones | Gaffer |
| Alex Pierre | Grip |
| Dean Smollar | Steadicam Operator |
| Amina Zadeh | Second Assistant Camera |
| Olney Atwell | Animation |
| Cody Vondell | Animation |
| Bridget Chapman | Assistant Costume Designer |
| Christy Hauptman | Costume Consultant |
| Sally Lyons | Color Assistant |
| Rigoberto Madrigal | Color Assistant |
| Shane Reed | Colorist |
| Tony Nawrocki | Location Manager |
| David Dahlquist | Additional Music |
| Samuel Dent | Sound Engineer |
| Nathaniel Motte | Scoring Mixer |
| Nathaniel Motte | Music Supervisor |
| Jesse Shatkin | Scoring Mixer |
| Jesse Shatkin | Music Supervisor |
| Raphie Del Mese | Production Coordinator |
