 | Bruce Willis als Ben Jordan |
 | Michelle Pfeiffer als Katie Jordan |
 | Rob Reiner als Stan Kogen |
 | Colleen Rennison als Erin Jordan (at Ten) |
 | Jake Sandvig als Josh Jordan (at Twelve) |
 | Julie Hagerty als Liza |
 | Rita Wilson als Rachel Kogen |
 | Paul Reiser als Dave |
 | Red Buttons als Arnie Jordan |
 | Betty White als Lillian Jordan |
 | Jayne Meadows als Dot |
 | Tom Poston als Harry |
 | Casey Boersma als Josh Jordan (at Two and a Half) |
| Dylan Boersma als Josh Jordan (at Three) |
 | Ken Lerner als Dr. Rifkin |
 | Albert Hague als Dr. Siegler |
 | Michael Chapman als Waiter |
 | Jessie Nelson als Realtor |
 | Bill Kirchenbauer als Eddie Kirby (wrongly listed as "Andy" in credits) |
| Norman Fessler als Maitre'd (uncredited) |
| Jessie Nelson | Producer |
| Michael Chapman | Director of Photography |
| Jessie Nelson | Screenplay |
| Robert Leighton | Editor |
| Alan Zweibel | Screenplay |
| Rob Reiner | Producer |
| Alan Edward Bell | Editor |
| Rob Reiner | Director |
| Alan Zweibel | Producer |
| Marc Shaiman | Original Music Composer |
| Eric Clapton | Original Music Composer |
| Jeffrey Stott | Executive Producer |
| Ralph Nelson Jr. | Still Photographer |
| Robert Eber | Sound Mixer |
| Scott Stambler | Music Editor |
| Greg P. Russell | Sound Re-Recording Mixer |
| Yann Delpuech | Sound Effects Editor |
| Christopher Burian-Mohr | Art Direction |
| Kerry Lyn McKissick | Script Supervisor |
| Elizabeth Flaherty | Art Department Coordinator |
| Frank Capra III | Executive Producer |
| Kevin O'Connell | Sound Re-Recording Mixer |
| Frank Capra III | First Assistant Director |
| Jess Gonchor | Art Direction |
| Tammy Glover | Associate Producer |
| Lilly Kilvert | Production Design |
| Shay Cunliffe | Costume Design |
| Sarah Jackson Burt | Set Decoration |
| Kathy Lucas | Set Decoration |
| Todd Y. Murata | Second Assistant Director |
