 | Julianne Moore als Cara Harding |
 | Jonathan Rhys Meyers als David / Adam / Wesley |
 | Jeffrey DeMunn als Dr. Harding |
 | Frances Conroy als Mrs. Bernburg |
 | Nate Corddry als Stephen Harding |
 | Brooklynn Proulx als Sammy |
 | Brian Anthony Wilson als Virgil |
| Joyce Feurring als Granny Holler Witch |
 | Steven Rishard als Detective Danton |
 | Charles Techman als Montgomery Hughes |
 | John Peakes als Doctor Charles Foster |
 | Michael Graves als Holler Man |
 | Chaz Moneypenny als Adam Sabre - Host |
 | Charles David Richards als Holiday Inn Bar Keep |
 | Rick Applegate als Warden Collins |
 | Loretta Higgins als Lady Doctor |
 | Tamara Johnson als Librarian |
| James Howard als Missouri D.A. |
| David Dale McCue als Prison Guard |
 | Diane Jonardi als Granny Holler Witch 1918 |
 | Jules Sylvester als Older Man |
 | KatiAna Davis als Little Girl Holler / Familiar |
 | Michael Mihalich als Governor |
 | Irene Ziegler als Doll Shopkeeper |
 | Giovanna Yannotti als Lawyer |
| Stephanie Macdougall als Diner Patron |
| Måns Mårlind | Director |
| Steve Mirkovich | Editor |
| Björn Stein | Director |
| Linus Sandgren | Director of Photography |
| John Frizzell | Original Music Composer |
| Michael Cooney | Screenplay |
| Jesse Rosenthal | Art Direction |
| Jesse Rosenthal | Set Decoration |
| Mike Macari | Producer |
| Diane Heery | Casting |
| Emilio Diez Barroso | Producer |
| Neal Edelstein | Producer |
| Tim Galvin | Production Design |
| Luca Mosca | Costume Design |
| Jason Loftus | Casting |
| Luke Guidici | Other |
| Kevin Kaska | Orchestrator |
| Darlene Caamano Loquet | Producer |
| Patty Bell | Makeup Artist |
| Lee Grimes | Key Makeup Artist |
| Mike Matesic | Construction Coordinator |
| Susan Reilly LeHane | Makeup Artist |
| Nicholas J. Romanac | Property Master |
| Francine Byrne | Art Department Coordinator |
| Annemarie Bradley | Key Hair Stylist |
| Edward Knott III | Dolly Grip |
| Jim Bridges | Still Photographer |
| Ken Gorrell | Special Effects Coordinator |
| Ruth Hernandez | ADR Editor |
| Philip Tallman | Music Editor |
| John Bires | Sound Engineer |
| Catherine Riley | Key Costumer |
| Stan Keitt | First Assistant Camera |
| Jen Painter | Casting Assistant |
| Mo Henry | Negative Cutter |
| Nancy Mosser | Casting |
| Regina Haigh | Casting Assistant |
| Peter Luong | Visual Effects Coordinator |
| Peter Staubli | Sound Effects Editor |
| Steve Drellich | Camera Operator |
| Mark Freund | Visual Effects Supervisor |
| Dawn Llewellyn | Digital Intermediate |
| Peter Luong | Digital Intermediate |
| Ilene Pickus | Script Supervisor |
| Mike L. Germaine | Dolly Grip |
| Jason Loftus | Casting Associate |
| Diane Collins | Costume Supervisor |
| Jesse Wagler | Digital Intermediate |
| Matthew E. Taylor | Dialogue Editor |
| Patrick Murray | Chief Lighting Technician |
| Humberto Recio | Electrician |
| Rick Sparr | Visual Effects Producer |
| Marc Varisco | Visual Effects Supervisor |
| Karen Vassar Triest | Sound Effects Editor |
| Gary Summers | Sound Re-Recording Mixer |
| Gordy Jorian | Electrician |
| Kimberly Covate | Visual Effects Producer |
| Zachary Tucker | Visual Effects Technical Director |
| Cindy Bond | Digital Intermediate |
| Marc Wostak | Best Boy Electrician |
| Andrew Fisher | First Assistant Camera |
| Cherokee Walker | Pilot |
| Chad Djubek | Boom Operator |
| David Baldwin | Sound Effects Editor |
| Bruce Hazen | Electrician |
| Peter Martorano | Location Manager |
| Ben Wilkins | Sound Effects Editor |
| Rich Toenes | Sound Engineer |
| David Norris | Aerial Director of Photography |
| Frank Spiziri | Visual Effects Coordinator |
| Mike Eaves | Digital Intermediate |
| Ross Jones | Key Grip |
| David Young | Sound Engineer |
| Sandy Hays | Steadicam Operator |
| Zoran Zdrnja | Electrician |
| Christopher Johnston | First Assistant Editor |
| Todd Orr | Sound Re-Recording Mixer |
| Gregg Baxter | Supervising Sound Editor |
| Christopher M. Fisher | First Assistant Camera |
| Jodi Michelle Pynn | Stunt Double |
