 | Jeffrey Wright als Thelonious 'Monk' Ellison |
 | John Ortiz als Arthur |
 | Erika Alexander als Coraline |
 | Leslie Uggams als Agnes Ellison |
 | Sterling K. Brown als Clifford Ellison |
 | Skyler Wright als Brittany |
 | John Ales als Leo |
 | Patrick Fischler als Mandel |
 | Carmen Cusack als Gilda |
 | Joseph Marrella als Matthew Wilson |
| Stephen Burrell als Jordan Phillips |
 | Issa Rae als Sintara Golden |
| Nicole Kempskie als Sintara's Moderator |
 | Becki Dennis als Clinic Receptionist |
 | Tracee Ellis Ross als Lisa Ellison |
 | Myra Lucretia Taylor als Lorraine |
| Ryan Richard Doyle als Ned |
 | Kate Avallone als Woman on Patio |
 | Dustin Tucker als Phillip |
 | Michael Jibrin als Jelani |
 | Michele Proude als Bulger's Nurse |
 | David De Beck als Dr. Bulger |
 | Okieriete Onaodowan als Van Go Jenkins |
 | Keith David als Willy the Wonker |
 | Miriam Shor als Paula Baderman |
 | Raymond Anthony Thomas als Maynard |
 | Greta Quispe als Luz Borquez |
 | J.C. MacKenzie als Carl Brunt |
| Elle Sciore als Layne |
 | Adam Brody als Wiley Valdespino |
 | Justin Andrew Phillips als Arthur's Intern |
 | Neal Lerner als Wilson Harnet |
 | Jenn Harris als Ailene Hoover |
 | Bates Wilder als Jon Daniel Sigmarsen |
| Jason Armani Martinez als Nursing Home Orderly |
 | Michael Cyril Creighton als John Bosco |
 | Celeste Oliva als Dr. Tiefel |
 | Megan Robinson als Kenya Dunston |
| Christopher Barrow als Burt |
 | Alexander Pobutsky als Kenny |
| Tokunbo Joshua Olumide als Alvin |
| Chhoyang Cheshatsang als Wiley's Assistant |
 | Michael Malvesti als Plainclothes Cop |
 | Samantha Gordon als Gaby (uncredited) |
| Cord Jefferson | Director |
| Cord Jefferson | Writer |
| Ben LeClair | Producer |
| Nikos Karamigios | Producer |
| Jermaine Johnson | Producer |
| Cord Jefferson | Producer |
| Percival Everett | Novel |
| Ram Bergman | Executive Producer |
| Michael Bowes | Executive Producer |
| Percival Everett | Executive Producer |
| Rian Johnson | Executive Producer |
| Hannah Offer | Associate Producer |
| Lenny Payan | Co-Producer |
| Laura Karpman | Original Music Composer |
| Cristina Dunlap | Director of Photography |
| Hilda Rasula | Editor |
| Jennifer Euston | Casting |
| Jonathan Guggenheim | Production Design |
| Maddy Young | Art Direction |
| Kyra Friedman Curcio | Set Decoration |
| Rudy Mance | Costume Design |
| Michele Lewis | Makeup Department Head |
| Emily Baeza | Second Assistant Director |
| Michael A. Myles | Set Dresser |
| Alexandra Fehrman | Sound Re-Recording Mixer |
| Santino Tartaglia | Utility Sound |
| Richard Weingart | Sound Re-Recording Mixer |
| Mandell Winter | Supervising Sound Editor |
| Tommy Carroll | Special Effects Technician |
| Melissa Morris | Casting Associate |
| S.J. Allocco | Casting Associate |
| Tina Ulee | Costume Supervisor |
| Wesley Cannon | Grip |
| Xavier Thompson | "A" Camera Operator |
| Monique Peoples Graham | Key Hair Stylist |
| Daniel Hourihan | Rigging Gaffer |
| Brett Duffy | Extras Casting |
| John Vincent Mason | Stunt Coordinator |
| Giles Harding | Visual Effects Supervisor |
| Stephen Hartman | Location Manager |
| Julie Glaze Houlihan | Music Supervisor |
| Alex Levy | Music Editor |
| Chris Analoro | Set Dresser |
| Shadya H. Ballug | Set Dresser |
| Jamie Joseph | Set Dresser |
| Kayla Mitchell | Set Dresser |
| Kendall Pestana | Set Dresser |
| Hashim Strange | Set Dresser |
| Julia Liu | "B" Camera Operator |
| Katherine Castro | "B" Camera Operator |
| Mattie Hamer | Digital Imaging Technician |
| Claire Folger | Still Photographer |
| Frankie Ferrari | Script Supervisor |
| Alec Roy | Gaffer |
| Gianna Sparacino | Hair Department Head |
| Felicia Leatherwood | Makeup Artist |
| Adam Bellao | Special Effects Coordinator |
| Sang Kim | Supervising Sound Editor |
| Matt Yocum | Supervising Sound Editor |
| Igor Yashin | Foley Editor |
| Pavel Nivevskiy | Foley Mixer |
| Ian Yeromenko | Foley Artist |
| Mehrnaz Mohabati | ADR Mixer |
| Taylor Armstrong | Main Title Designer |
| Jill Sacco | Production Supervisor |
| Jill Tufts | First Assistant "A" Camera |
| Audrey L. Stevens | Second Assistant "A" Camera |
| Chris Hebert | First Assistant "B" Camera |
| Felix Giuffrida | First Assistant "B" Camera |
| Clint Porte | Second Assistant "B" Camera |
| Anthony Farenwald | Grip |
| Zachary Heyman | Grip |
| Walter Argo | Dolly Grip |
| Tony Ventura | Key Grip |
| Jeff Dionne | Assistant Location Manager |
| Sydney Sherrell | Assistant Location Manager |
| David Becker | Location Coordinator |
| Andie Turner | Location Scout |
| Tyler Kinney | Assistant Costume Designer |
| Ian Davis | Location Assistant |
| Candace Masterson | Key Costumer |
| Alana Frutkoff | Set Costumer |
| Emily Conner | Tailor |
| Corine Shannon | Costume Assistant |
| Lily Raih | Property Master |
| Diz Dizio | Assistant Property Master |
| John Burke | Set Dresser |
| Finley Doyle | Graphic Designer |
| Augustus Augustus | Art Department Production Assistant |
| Emilie Toth | Art Department Production Assistant |
| Chris Sawtelle | Leadman |
| Layla Calo-Baird | Set Buyer |
| Jake Swartz | Art Department Coordinator |
| Jake Swartz | Set Decorating Coordinator |
| Christopher Conkling | Production Accountant |
| Julie Hansen | Post Production Accountant |
| Joshua Manning | On Set Dresser |
| Charmaine Cavan | First Assistant Editor |
| Dan Watson | Associate Producer |
| Xavier Thompson | Steadicam Operator |
| Jovan Tanasijevic | Drone Pilot |
| Giles Harding | Visual Effects Producer |
| Lisa Lobel | Local Casting |
| William O'Brien | Transportation Coordinator |
| Ryan P. Sheehan | Transportation Captain |
| Ashley Lambert | ADR Voice Casting |
| Louisa Hager | Thanks |
| Leslie LeClair | Thanks |
| Hayley Denny | Thanks |
| Wilson Clifford Jefferson, Jr. | Thanks |
| Prasanna Kodapadi | Visual Effects Supervisor |
| Gokul Mahajan | Visual Effects Supervisor |
| Kapil More | Visual Effects Supervisor |
| Vadlakonda Satish | Visual Effects Producer |
| Kiran Matta | Visual Effects Producer |
| Chuck Giarratano | Executive Visual Effects Producer |
| Ian Fellows | Visual Effects Supervisor |
| Rosalien van der Bom | Visual Effects Producer |
| Jasper Affonso | Visual Effects Editor |
| Pranay Lathia | Visual Effects Production Assistant |
| Bruce Wayne Gillies | Line Producer |
| Karla Marie Christensen | First Assistant "A" Camera |
| Jill Crawford | Set Decoration |
| Greg Arch | "A" Camera Operator |
| Greg Arch | Steadicam Operator |
| Sasha Wright | Second Assistant "A" Camera |
| Teddy Phu-Thanh-Danh | Digital Imaging Technician |
| Justin Garcia | Gaffer |
| Lev Abrahamian | Key Grip |
| Carlton Hudson | Dolly Grip |
| Haley Vigil | Costume Supervisor |
| Coco Dunaway | Key Costumer |
| Catherine Jelski | Script Supervisor |
| Mimi Gillies | Unit Production Manager |
| Mimi Gillies | First Assistant Director |
| Rachel Rodgers | Second Assistant Director |
| Tiffany Wu | Second Second Assistant Director |
| Michael Crumley | Production Sound Mixer |
| Jim Otero | Transportation Captain |
| Christian Lainez | Boom Operator |
| Nichelle Young | Hair Department Head |
| Galaxy San Juan | Makeup Department Head |
| Lisa Morgan | Key Makeup Artist |
| Treven Bedwell | Property Master |
| Cutter Ray Palacios | Set Medic |
| Elizabeth Ayoob | Casting Associate |
| Shayne Hartigan | Extras Casting |
| Jared Detsikas | Production Sound Mixer |
| Harry McEnerny | Second Second Assistant Director |
| Haley Hebert | Key Set Production Assistant |
| Dante Haughton | Set Production Assistant |
| Scott Kamp | Set Production Assistant |
| Ismah Khan | Set Production Assistant |
| Cameron Prata | Set Production Assistant |
| Julia Roveto | Set Production Assistant |
| Selena Evans-Miller | Key Makeup Artist |
| Frederick Sanders | Makeup Artist |
| Kelly Doran | Boom Operator |
