 | Kyle Mooney als James Pope |
 | Mark Hamill als Ted Mitchum |
 | Jorge Lendeborg Jr. als Spencer |
 | Matt Walsh als Greg Pope |
 | Michaela Watkins als Louise Pope |
 | Ryan Simpkins als Aubrey Pope |
 | Greg Kinnear als Detective Vogel |
 | Alexa Demie als Meredith |
 | Beck Bennett als Detective Bander |
 | Claire Danes als Emily |
 | Chance Crimin als Logan |
 | Jane Adams als April Mitchum |
 | Andy Samberg als Eric |
 | Kate Lyn Sheil als Arielle Smiles |
| James Anthony Green als Police Officer |
| Kim Fischer als Female Reporter |
| Kelly Chapman als News Anchor |
 | Nick Rutherford als Brigsby Bear fan |
| Reagan Pineda als Reality Talking Head |
| Kiera Milan Hendricks als Young Smiles Sisters |
 | Tim Heidecker als Coach Brad |
| Rex Morgan als Gordo |
| Ellery Davidson als Hannah Slice |
| Christopher Sullivan als FBI Agent |
| Joseph Paul Branca als Space Alien |
 | Nikolas Mikkelsen als Theatre Patron |
| Matthew P. Watts als Prison Guard |
| Ashlyn Brooke Anderson als Wizzle Prince (uncredited) |
 | Yvonne D Bennett als Party Guest (uncredited) |
 | Kami Christiansen als Nurse (uncredited) |
| Paul Nathan Cuthbert als Prison Visitor (uncredited) |
 | Teresa Duran-Norvick als Premiere Audience (uncredited) |
 | Gerry Garcia als (uncredited) |
| Angella Joy als Reporter (uncredited) |
 | Marilyn Miller als Court Reporter (uncredited) |
 | Chris Provost als Prison Guard (uncredited) |
| Seth Williams als Cameraman (uncredited) |
| Christian Sprenger | Director of Photography |
| Dave McCary | Director |
| Kevin Costello | Writer |
| Kyle Mooney | Writer |
| David Wingo | Original Music Composer |
| Jacob Craycroft | Editor |
| Sarah Mae Burton | Costume Design |
| Brandon Tonner-Connolly | Production Design |
| Al Di | Producer |
| Will Allegra | Producer |
| Andy Samberg | Producer |
| Billy Rosenberg | Producer |
| Christopher Miller | Producer |
| Akiva Schaffer | Producer |
| Phil Lord | Producer |
| Jorma Taccone | Producer |
| Phil Hoelting | Executive Producer |
| Ross Jacobson | Executive Producer |
| Becky Roundy | Special Effects |
| Leslie Shatz | Supervising Sound Editor |
| Ryan Roundy | Special Effects Coordinator |
| Danny Gray | Boom Operator |
| James David Redding III | Sound Editor |
| Jason Zaro | Co-Producer |
| Michael Roundy | Special Effects Technician |
| Abigail Steele | Key Makeup Artist |
| Amanda Carrara | Second Assistant Director |
| Bobbi Murphy | Key Hair Stylist |
| Matthew Medlin | Line Producer |
| Cynthia A. Neibaur | Set Decoration |
| Ryan Pedersen | Boom Operator |
| Jonathon 'Earl' Stein | Sound Mixer |
| Chuck Roundy | Special Effects Technician |
| Andy Eklund | Art Direction |
| Lora Laing | Hair Department Head |
| Andrew Sherman | Visual Effects |
| Jon Flores | Sound Editor |
| Lian Hua | Executive Producer |
| Tony Pachella | Associate Producer |
| Jonathan Ferrantelli | Post Production Supervisor |
| Carlos Sotolongo | ADR Mixer |
| P. Jennifer Dana | Producer |
| Jennifer Chapman | Production Supervisor |
| Greg T. Moon | Makeup Department Head |
| M. Ryan Traylor | First Assistant Director |
| Leslie Bloome | Foley Artist |
| Andrew Swett | Associate Producer |
| Eliza Coleman | Stunt Coordinator |
| Mark Roberts | Producer |
| Allie Lane | Assistant Art Director |
| Scott b Schmidt | Set Dresser |
| Lonzo Liggins | Stunt Driver |
| Bernard Evans | "A" Camera Operator |
| Cody Jacobs | Gaffer |
| Jed Seus | Steadicam Operator |
| Brian Sullivan | Camera Operator |
| Alexis Winter | Casting Associate |
| Courtney Bright | Casting |
| Nicole Daniels | Casting |
