 | Dennis Hopper als Milo |
 | Jodie Foster als Anne Benton |
 | Dean Stockwell als John Luponi |
 | Vincent Price als Mr. Avoca |
 | John Turturro als Pinella |
 | Fred Ward als Pauling |
 | Julie Adams als Martha |
 | Tony Sirico als Greek |
 | Charlie Sheen als Bob |
 | Joe Pesci als Leo Carelli |
 | Catherine Keener als Trucker's girl |
 | Sy Richardson als Capt. Walker |
 | Frank Gio als Frankie |
 | Satya De La Manitou als Car Thug |
 | Helena Kallianiotes als Grace Carelli |
 | John Apicella als Man at Refinery |
 | Katherine LaNasa als Waitress |
 | Anthony Pena als Taos Sheriff |
 | Sarina C. Grant als Hooker |
 | Tomás Goros als Golf Course Fed |
 | Lauren Lloyd als Margaret Mason |
 | Michael Yama als Technician |
 | Bob Dylan als Artist (uncredited) |
| Joe Pesci als Leo Carelli (uncredited) |
 | Ted Markland als Man in Van (uncredited) |
 | Toni Basil als (uncredited) |
 | Alex Cox als D.H. Lawrence (uncredited) |
| David E. Harshbarger als Free Base Cocaine User (uncredited) |
 | Grand L. Bush als Bank Teller (as Grand Bush) |
 | Robert Rothwell als Ad Agency Exec |
| Dennis Hopper | Director |
| Rachel Kronstadt Mann | Screenplay |
| Curt Sobel | Original Music Composer |
| Rachel Kronstadt Mann | Story |
| Ann Louise Bardach | Screenplay |
| Edward Lachman | Director of Photography |
| David Rawlins | Editor |
| Lauren Lloyd | Casting |
| Ron Foreman | Production Design |
| Nancy Cone | Costume Design |
| Jeannie Laughlin | Set Decoration |
| Joyce King | Script Supervisor |
| James M. Tanenbaum | Sound Mixer |
| Robert L. Hoyt | Sound Re-Recording Mixer |
| Jeffrey Perkins | Sound Re-Recording Mixer |
| Doug Botnick | Sound Re-Recording Mixer |
| Paul Lewis | Line Producer |
| Steven Reuther | Executive Producer |
| Mitchell Cannold | Executive Producer |
| Lisa Demberg | Co-Producer |
| Dan Paulson | Producer |
| Dick Clark | Producer |
| Janet Brady | Stunt Double |
| Pat Gerhardt | Makeup Artist |
| Leslie Ann Anderson | Hairstylist |
| Glenn R. Wilder | Stunts |
| David R. Ellis | Stunts |
| Gary McLarty | Stunts |
| Jeffrey J. Dashnaw | Stunts |
| Eddy Donno | Stunt Coordinator |
| Mark Giardino | Stunts |
| Buddy Joe Hooker | Stunts |
| Chris Howell | Stunts |
| Vic Manni | Stunts |
| Tommy J. Huff | Stunts |
| Tony Donno | Stunts |
| Beth Nufer | Stunts |
| Hugo Cortina | Chief Lighting Technician |
| Ronald Batzdorff | Still Photographer |
| Dale L. Martin | Special Effects Coordinator |
| Randall Badger | Second Assistant Director |
| Craig Beaudine | First Assistant Director |
